Osteoarthritis and comorbidity: pathogenetic links

A. Fatenko; Elena Belyaeva

doi:10.12737/2409-3750-2023-9-2-31-36

UDC

616-06 61

OSTEOARTHRITIS AND COMORBIDITY: PATHOGENETIC LINKS Osteoarthritis and comorbidity: pathogenetic links

АА Аа

Published in Clinical Medicine and Pharmacology · Pages 31–36 · Rubric: reviews

DOI: https://doi.org/10.12737/2409-3750-2023-9-2-31-36

Received: 11.12.2023 Accepted: 12.12.2023 Published: 12.12.2023

Authors

A. Fatenko

Elena Belyaeva

A. Fatenko

Tula State University medicinskiy institut

Elena Belyaeva

Tula State University professor · medicinskiy institut

ABSTRACT

Secondary inflammatory processes, primarily synovitis, accompany the course of osteoarthritis, play a significant role in the formation of both clinical manifestations of the disease and further destruction of articular structures. In a patient with osteoarthritis over the age of 50, more than 5 diseases coexist simultaneously and there are practically no persons who do not have concomitant somatic diseases. Atherosclerosis refers to inflammatory diseases in which inflammation is associated with dyslipidemia and chronic immune dysregulation. It has been established that one of the main elements of atherothrombosis is an increase in the synthesis of proinflammatory cytokines. Common risk factors for primary osteoarthritis and cardiovascular diseases: age, overweight, heredity, metabolic disorders (high cholesterol, glucose tolerance, diabetes mellitus).

KEYWORDS

osteoarthritis, comorbidity, cytokines, c-reactive protein, metabolic disorders

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Vladislav Belyaev

vladis.belyaev@yandex.ru +7(910)584-92-40

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GOST

Fatenko A. S., Belyaeva E. A. Osteoarthritis and comorbidity: pathogenetic links // Clinical Medicine and Pharmacology. 2023. no. 2. pp. 31-36. DOI: https://doi.org/10.12737/2409-3750-2023-9-2-31-36. (Date of access 10.09.2026).

MLA

A. Fatenko, Belyaeva E. A.. "Osteoarthritis and comorbidity: pathogenetic links." Clinical Medicine and Pharmacology 9.2 (2023): 31-36. DOI: https://doi.org/10.12737/2409-3750-2023-9-2-31-36.

APA

Fatenko A. S., Belyaeva E. A. (2023). Osteoarthritis and comorbidity: pathogenetic links. Clinical Medicine and Pharmacology, 9(2), 31-36. https://doi.org/10.12737/2409-3750-2023-9-2-31-36

Chicago

A. Fatenko, Belyaeva E. A.. "Osteoarthritis and comorbidity: pathogenetic links." Clinical Medicine and Pharmacology 9, no. 2 (2023): 31-36. https://doi.org/10.12737/2409-3750-2023-9-2-31-36.

WIKI

{{cite journal | author = Fatenko A. S., Belyaeva E. A. | title = Osteoarthritis and comorbidity: pathogenetic links | journal = Clinical Medicine and Pharmacology | year = 2023 | volume = 9 | issue = 2 | pages = 31-36 | doi = 10.12737/2409-3750-2023-9-2-31-36 }}

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OSTEOARTHRITIS AND COMORBIDITY: PATHOGENETIC LINKS Osteoarthritis and comorbidity: pathogenetic links

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