Our website uses cookies. By continuing to use this site, you agree to our use of cookies in accordance with this notice and the Terms of Use.
Journals Monographies Textbooks Collections Authors
Submit manuscript
Medical Radiology and radiation safety

NUCLEAR MEDICINE IN DIAGNOSIS OF ANGIOPATHY IN PATIENTS WITH DIABETES MELLITUS TYPE 2 Nuclear Medicine in Diagnosis of Angiopathy in Patients with Diabetes Mellitus Type 2

Published in Medical Radiology and radiation safety · Pages 56–64 · Rubric: Review
DOI: https://doi.org/10.12737/25062
Received: 14.03.2017 Accepted: 14.03.2017 Published: 14.03.2017 Language of publication: RUS
Authors
A.
A. Nikitin
D.
D. Y. Mosin
A.
A. K. Kondakov
T.
T. Poletaeva
D.
D. Kharina
I.
I. A. Znamenskiy
ABSTRACT
Purpose: To determine the role of nuclear medicine techniques in the early detection of angiopathy in patients with diabetes and to estimate their accuracy in comparison with routine diagnostic methods for evaluation of target organ damage. Material and methods: A literature review, selected from the Russian and international bibliographic databases (RSCI, Medline, Google Scholar), dedicated to diagnostic technologies for identification of angiopathy in patients with diabetes mellitus. Results: 193 sources dedicated to the diagnosis of micro- and macrovascular damage were analyzed, 66 of which were included in this study, 54 of them international and 12 domestic ones responding to the purpose of the study. The analysis revealed that the radionuclide methods of investigation reflecting the functional state of the tissues were evaluated in a small number of publications on early diagnosis angiopathy caused by diabetes mellitus type 2. Most often, high blood glucose concentration damages kidney tissue and myocardium. It is shown that the methods of dynamic nephroscintigraphy and ECG- gated myocardial perfusion SPECT allow to evaluate the progression of micro- and macrovascular disease before the manifestation of paraclinical signs according to other diagnostic methods. Key determined parameter in dynamic nephroscintigraphy is glomerular filtration rate, which declines on the early stages of the disease. Myocardial perfusion SPECT imaging provides a possibility to assess frequency and severity of ischemic myocardial injury. Conclusions: The use of nuclear medicine techniques in the diagnosis of angiopathy in diabetes allows verification of early damage to target organs. The most effective diagnostic methods for this purpose are dynamic nephroscintigraphy and myocardial perfusion SPECT which sensitivity is substantially higher than conventional diagnostic methods.
KEYWORDS
diabetes mellitus type 2, nuclear medicine, dynamic nephroscintigraphy, myocardial perfusion imaging, impaired glucose tolerance
Text References
Text

Сахарный диабет второго типа (СДВТ) – широко распространенное в человеческой популяции хроническое заболевание, которое сопровождается нарушением обмена углеводов, стойким увеличением показателей глюкозы крови, вследствие инсулиновой недостаточности, секреторной дисфункции β-клеток, а также негативными изменениями липидного обмена с развитием атеросклероза.

1. Ametov A.S., Kurochkin I.O., Zubkov A.A. Saharnyj diabet I serdechno-sosudistye zabolevanija. // Russkij medicinskij zhurnal. 2014. T. 13. S. 954.

2. Roglic G. et al. The burden of mortality attributable to diabetes: realistic estimates for the year 2000 // Diabetes Care. 2005. Vol. 28. No 9. P. 2130-2135.

3. Halter J.B. et al. Diabetes and cardiovascular disease in older adults: current status and future directions // Diabetes. 2014. Vol. 63. No 8. P. 2578-2589.

4. Chowdhury R. et al. Genetic studies of type 2 diabetes in South Asians: a systematic overview // Curr. Diabetes Rev. 2014. Vol. 10. No 4. P. 258-274.

5. Neumann A. et al. Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Vasterbotten Sweden // Heal. Qual. Life Outcomes. 2014. Vol. 12. No 1. P. 150-156.

6. Murtagh G. et al. Importance of risk factor management in diabetic patients & reduction in stage B heart failure // QJM. 2014.

7. Dedov I.I., Balabolkin M.I., Marova E.I. Bolezni organov jendokrinnoj sistemy: Book / ed. Dedov I.I. M.: Medicina, 2000. 568 s.

8. Balabolkin, M.I., Klebanova, E.M., Kreminskaja V.M. Sovremennye voprosy klassifikacii, diagnostiki i kriterii kompensaci saharnogo diabeta // Saharnyj diabet. 2003. T. 10. S. 5.

9. Cugnet C., Thivolet C. Classification of diabetes in young adults: new concepts for an old disease // Diabetes Metab. 2005. Vol. 31. No 6. P. 595-598.

10. Cusnir V., Cusnir V. Jr., Bendelic E. Diabetic retinopathy, practical value of classification // Oftalmologia. 2010. Vol. 54. No 3. P. 61-65.

11. Kawasaki S. et al. Relationship between coronary artery disease and retinopathy in patients with type 2 diabetes mellitus // Intern. Med. 2013. Vol. 52. No 22. P. 2483-2487. Chantelau E.A., Grutzner G. Is the Eichenholtz classification still valid for the diabetic Charcot foot? Journal Article // Swiss Med. Wkly. 2014. Vol. 144. P. w13948.

12. Edo A.E., Okaka E., Ezeani I.U. Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus // Niger J. Clin. Pr. 2014. Vol. 17. No 5. P. 658-661.

13. Vahora R., Thakkar S., Marfatia Y. Skin, a mirror reflecting diabe­ tes mellitus: A longitudinal study in a tertiary care hospital in Gu­ jarat // Indian J. Endocrinol. Metab. 2013. Vol. 17. No 4. P. 659-664.

14. Hellgren K.J., Agardh E., Bengtsson B. Progression of early retinal dysfunction in diabetes over time: results of a long-term prospec­ tive clinical study // Diabetes. 2014. Vol. 63. No 9. P. 3104-3111.

15. Liu M. et al. Cardiovascular disease and its relationship with chronic kidney disease // Eur. Rev. Med. Pharmacol. Sci. 2014. Vol. 18. No 19. P. 2918-2926.

16. Aggarwal A., Aggarwal S., Sharma V. Cardiovascular risk factors in young patients of coronary artery disease: differences over a decade // J. Cardiovasc. Thorac. Res. 2014. Vol. 6. No 3. P. 169-173.

17. Kakrani A.L. et al. Clinical and nerve conduction study correlation in patients of diabetic neuropathy // J. Assoc. Physicians India. 2014. Vol. 62. No 1. P. 24-27.

18. Vukojevic Z. et al. Correlation of clinical and neurophysiological

19. findings with health-related quality of life in patients with diabetic polyneuropathy // Vojn. Pregl. 2014. Vol. 71. No 9. P. 833-838.

20. Saraswathy R. et al. Chromosomal aberrations and exon 1 mutation in the AKR1B1 Gene in patients with diabetic neuropathy // Ochsner J. 2014. Vol. 14. No 3. P. 339-342.

21. Balabolkin M.I. Saharnyj diabet. - M.: Medicina, 1994.

22. van Eeckhoudt S. et al. Charcot spinal arthropathy in a diabetic patient // Acta Clin. Belg. 2014. Vol. 69. No 4. P. 296-298.

23. Lu Q. et al. Apelin in epiretinal membranes of patients with pro- liferative diabetic retinopathy // Mol. Vis. 2014. Vol. 20. P. 1122-1131.

24. Lim Ak. Diabetic nephropathy - complications and treatment // Int. J. Nephrol. Renov. Dis. 2014. Vol. 7. P. 361-381.

25. Efimov A.S. Diabeticheskie angiopatii. - M.: Medicina. 1989. 288 s.

26. Statsenko M.E., Derevianchenko M.V. Correction of endothelial dysfunction in hypertensive patients with type 2 diabetes mellitus during combined antihypertensive therapy // Ter. Arkh. 2014. Vol. 86. No 8. P. 90-93.

27. Tadzhієva D.Ch. et al. Dinamіchna renoscintigrafіja ta radіonuklіdna angіografіja v dіagnosticі doklіnіchnih form dіabetichnoї nefropatії : Journal Article // Ukr. radіol. zhurnal. 1999. Vol. 7, No 3. P. 254-258.

28. Mogensen C.E., Christensen C.K., Vittinghus E. The stages in diabetic renal disease with emphasis on the stage of incipient diabetic nephropathy // Diabetes. 1983. Vol. 32 Suppl 2. P. 64-78.

29. Damsgaard E.M., Mogensen C.E. Microalbuminuria in elderly hyperglycaemic patients and controls // Diabet Med. 1986. Vol. 3. No 5. P. 430-435.

30. Chen X. et al. In vivo evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria // Front Med. 2014. Vol. 5. P. 73-78.

31. Kim M.K. et al. Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment // Diabetes Metab. 2014. Vol. 5. No 4. P. 1000364.

32. Toste S. et al. Cardiac rehabilitation in patients with type 2 diabetes mellitus and coronary disease: A comparative study // Rev. Port. Cardiol. 2014. Vol. 33. P. 313-315.

33. Chiang H.H. et al. All-cause mortality in patients with type 2 diabetes in association with achieved hemoglobin a1c, systolic blood pressure, and low-density lipoprotein cholesterol levels // PLoS One. 2014. Vol. 9. No 10. P. e109501.

34. Yu L.B. et al. Detection rates of atherosclerosis by carotid versus lower limb ultrasonography in newly diagnosed type 2 diabetics // Zhonghua Yi Xue Za Zhi. 2013. Vol. 93. No 27. P. 2143-2145.

35. Bornfeldt K.E. 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis // Arter. Thromb Vasc. Biol. 2014. Vol. 34. No 4. P. 705-714.

36. Hayashi T. et al. Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes // Proc. Natl. Acad. Sci. USA. 2014. Vol. 111. No 3. P. 1168-1173.

37. Ametov A.S. Saharnyj diabet 2 tipa. Problemy i reshenija. Ucheb. pos.-2-e izd.. - M.: GJeOTAR-Media, 2014. 1032 s.

38. Anciferov M.B., Galstjan G.R., Milen’kaja T.M. Oslozhnenija saharnogo diabeta.Pod red. I.I. Dedova. - M.: Jendokrinologicheskij nauchnyj centr RAMN, 1995. 21 s.

39. Orasanu G., Plutzky J. The pathologic continuum of diabetic vas­ cular disease // J. Amer. Coll. Cardiol. 2009. Vol. 53. No 5 Suppl. P. S35-42.

40. Franch-Nadal J. et al. Differences in the cardiometabolic control in type 2 diabetes according to gender and the presence of cardiovascular disease: results from the eControl study // Int. J. Endocrinol. 2014. Vol. 2014. P. 131709.

41. Bergis D. et al. Coronary artery disease as an independent pre­ dictor of survival in patients with type 2 diabetes and Charcot neuro-osteoarthropathy // Acta Diabetol. 2014. Vol. 51. No 6. P. 1041-1048.

42. Cox A.J. et al. Contributors to mortality in high-risk diabetic patients in the diabetes heart study // Diabetes Care. 2014. Vol. 37. No 10. P. 2798-2803.

43. Juarez D.T. et al. Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience // Diabetes Metab. Syndr. Obes. 2014. Vol. 7. P. 487-494.

44. Ferrannini E. The target of metformin in type 2 diabetes // N. Engl. J. Med. 2014. Vol. 371. No 16. P. 1547-1548.

45. Ryden L. et al. Guidelines on diabetes, pre-diabetes, and cardio- vascular diseases: executive summary. The task force on diabetes and cardiovascular diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD) // Eur. Hear. J. 2007. Vol. 28. No 1. P. 88-136.

46. Gross J.L. et al. Diabetic nephropathy: diagnosis, prevention and treatment // Diabetes Care. 2004. Vol. 28. No 1. P. 42-48.

47. Fiorini F., Barozzi L. The role of ultrasonography in the study of medical nephropathy // J. Ultrasound. 2007. Vol. 10. No 4. P. 161-167.

48. Buturović-Ponikvar J., Visnar-Perovic A. Ultrasonography in chronic renal failure // Eur. J. Radiol. 2003. Vol. 46. No 2. P. 115-122.

49. Colagiuri S., Best J. Lipid-lowering therapy in people with type 2 diabetes // Curr Opin Lipidol. 2002. Vol. 13. No 6. P. 617-623.

50. Tatarchenko I.P. et al. Clinicofunctional evaluation of ischemic episodes and vascular endothelium in patients with type 2 diabetes // Klin. Med. 2006. Vol. 84. No 12. P. 31-34.

51. Petrii V. V, Mikova N. V, Makolkin V.I. Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus // Kardiologiia. 2007. Vol. 47. No 7. P. 22-25.

52. Young L.H. et al. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial // JAMA. 2009. Vol. 301. No 15. P. 1547-1555.

53. Saito T. et al. Painless myocardial ischemia during the treadmill test in the elderly // Rinsho Byori. 2004. Vol. 52. No 10. P. 799-803.

54. Kasim M. et al. Myocardial perfusion SPECT utility in predicting cardiovascular events among indonesian diabetic patients // Open Cardiovasc. Med. J. 2013. Vol. 7. P. 82-89.

55. Tabit C.E. et al. Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications // Rev. Endocr. Metab. Disord. 2010. Vol. 11. No 1. P. 61-74.

56. Harina, D.S., Servuli, E.A., Poletaeva, T.A. et al. Kompleksnaja radionuklidnaja diagnostika rannih oslozhnenij u pacientov s saharnym diabetom 2 tipa // Vestnik RNCRR. 2015. No. 15. P. 56-61.

57. Su Y. et al. Endothelial dysfunction in impaired fasting glycemia, impaired glucose tolerance, and type 2 diabetes mellitus // Amer. J. Cardiol. 2008. Vol. 102. No 4. P. 497-498.

58. Peix A. Usefulness of nuclear cardiology techniques for silent ischemia detection in diabetics // MEDICC Rev. 2013. Vol. 15. No 1. P. 33-36.

59. Bolus N.E. Nuclear medicine instrumentation // J. Nucl. Med. Technol. 2010. Vol. 38. No 3. P. 172-173.

60. Judin A.L. et al. Radionuklidnaja diagnostika.- M.: Izatel’skij dom: russkij vrach, 2012. 96 s.

61. Slavnov V.N., Savickij S.Ju. Radionuklidnye metody v diagnostike oslozhnenij saharnogo diabeta: // Arterial’naja gipertenzija. 2009. Vol. 2, No 4. С. 37-42.

62. Strabykina D.S., Servuli E.A., Kondakov A.K. i soavt. Rol’ metodov jadernoj mediciny v rannej diagnostike angiopatij pri saharnom diabete 2 tipa // Rossijskij Jelektronnyj Zhurnal Luchevoj Diagnostiki. Prilozhenie. Materialy VIII vserossijskogo nacional’nogo kongressa luchevyh diagnostov i terapevtov «Radiologija 2014». 2014. T. 3, No 2. S. 134.

63. Schepis T. et al. Prognostic value of stress-gated 99m-technetium SPECT myocardial perfusion imaging: risk stratification of patients with multivessel coronary artery disease and prior coronary revascularization // J. Nucl. Cardiol. 2013. Vol. 20. No 5. P. 755-762.

64. Lugomirski P., Chow B.J., Ruddy T.D. Impact of SPECT myocardial perfusion imaging on cardiac care // Expert Rev. Cardiovasc. Ther. 2014. Vol. 12. No 11. P. 1247-1249.

65. Siqueira M.E. et al. Diagnostic value of myocardial radionuclide imaging in patients with multivessel coronary disease // Arq. Bras. Cardiol. 2011. Vol. 97. No 3. P. 194-198.

66. Rijnierse M.T. et al. Impaired hyperemic myocardial blood flow is associated with inducibility of ventricular arrhythmia in ischemic cardiomyopathy // Circ Cardiovasc Imaging. 2014. Vol. 7. No 1. P. 20-30.

JATS XML
The contact persons
Scientific and Production Editor
Boris Narkevich
medradiol@yandex.ru
Indexing information will be added later
© INFRA-M
Agreement Personal data protection and processing policy Support Powered by Editorum, 2026 Instructions
Login or Create
* Forgot your password?