Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment

A. Basov; M. Shpakovskiy; N. Gribanov; I. Ardashev; Konstantin Kazanin; E. Nikitenko

doi:10.12737/13304

USE OF THE DRUG "PERPHTORAN" AND BIOACTIVE IMPLANTS WITH CALCIUM PHOSPHATE COATING IN SURGICAL TREATMENT OF FEMORAL NECK FRACTURES AT THE EXPERIMENT Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment

АА Аа

Published in Journal of New Medical Technologies · Volume 22, Issue 3 · Pages 73–79 · Rubric: Clinical Picture and Methods of Treatment. Functional and Instrumental Diagnostics. New Medicinal Forms

DOI: https://doi.org/10.12737/13304

Received: 28.09.2015 Accepted: 28.09.2015 Published: 28.09.2015 Language of publication: RUS

Authors

A. Basov

M. Shpakovskiy

N. Gribanov

I. Ardashev

et al.

Konstantin Kazanin

E. Nikitenko

A. Basov

M. Shpakovskiy

N. Gribanov

I. Ardashev

Konstantin Kazanin

E. Nikitenko

ABSTRACT

The purpose of the study was to improve the results of surgical treatment of femoral neck fractures by in-tra-osseous injection of oxygenated perphtoran in avascular femoral head and osteosynthesis implants with bioactive calcium phosphate coating in the experiment. Investigations were carried out on 68 male rabbits. Hip fracture was formed transcervically by osteotome and crosses private ligament of the femoral head. The authors studied the dynamics of radiological and morphological parameters of reparative osteogenesis in 3 groups of animals: the 1st group with the introduction of oxygenated perftoran in an avascular femoral head without osteosynthesis of the femoral neck; the 2nd group after osteosynthesis by implants with bioactive calcium phosphate coating; the 3rd group after injection of oxygenated perftoran in an avascular femoral head with osteosynthesis implants by bioactive calcium phosphate coating. In the group without osteosynthesis process the authors revealed the development of degenerative changes with bone resorption, the expansion of the fracture line, displacement of bone fragments and the formation of non-union of the femoral neck. Osteosynthesis of femoral neck fractures with calcium phosphate bioactive implants coating contributes to fracture healing. Analysis of the results of the morphological assessment of the perftoran effect of calcium phosphate coatings on reparative osteogenesis in experimental hip fracture allows to determine the less severe exudative phase of the inflammatory response and to accelerate bone formation in the group with oxygenated perftoran and titanium implants coated with calcium phosphate. Introduction of oxygenated perftoran in an avascular femoral head at the osteosynthesis of experimental hip fractures by bioactive implants coated with calcium phosphate promotes to bone regeneration processes on the basis of radiological and morphological data. This allows to fracture healing at an earlier date by reducing inflammatory infiltration in the area of the fracture and the direct inclusion of the implant with calcium phosphate coating in the process of reparative osteogenesis.

KEYWORDS

experiment, femoral neck, fractures, perftoran, osteosynthesis, calcium phosphate coating.

Text

Современные методы лечения переломов шейки бедра (ТТТБ), несмотря на многочисленные экспериментальные и клинические работы, сопровождаются высокой частотой несращений (11,1-51,1%), асептического некроза головки бедра (6,1-43%), неблагоприятных исходов и инвалидности - до 36,7% [2,4,7-9].

Одним из патогенетически обоснованных способов уменьшения побочных эффектов применения имплантатов для остеосинтеза является использование биоактивных имплантатов, способных к инте-

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Editor-in-Chief, editorial board chair

GOST

Basov A., Shpakovskiy M., Gribanov N., Ardashev I., Kazanin K., Nikitenko E. Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment // Journal of New Medical Technologies. 2015. no. 3. pp. 73-79. DOI: https://doi.org/10.12737/13304. (Date of access 02.10.2026).

MLA

A. Basov, Shpakovskiy M., Gribanov N., Ardashev I., Kazanin K., Nikitenko E.. "Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment." Journal of New Medical Technologies 22.3 (2015): 73-79. DOI: https://doi.org/10.12737/13304.

APA

Basov A., Shpakovskiy M., Gribanov N., Ardashev I., Kazanin K., Nikitenko E. (2015). Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment. Journal of New Medical Technologies, 22(3), 73-79. https://doi.org/10.12737/13304

Chicago

A. Basov, Shpakovskiy M., Gribanov N., Ardashev I., Kazanin K., Nikitenko E.. "Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment." Journal of New Medical Technologies 22, no. 3 (2015): 73-79. https://doi.org/10.12737/13304.

WIKI

{{cite journal | author = Basov A., Shpakovskiy M., Gribanov N., Ardashev I., Kazanin K., Nikitenko E. | title = Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment | journal = Journal of New Medical Technologies | year = 2015 | volume = 22 | issue = 3 | pages = 73-79 | doi = 10.12737/13304 }}

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USE OF THE DRUG "PERPHTORAN" AND BIOACTIVE IMPLANTS WITH CALCIUM PHOSPHATE COATING IN SURGICAL TREATMENT OF FEMORAL NECK FRACTURES AT THE EXPERIMENT Use of the Drug "Perphtoran" and Bioactive Implants with Calcium Phosphate Coating in Surgical Treatment of Femoral Neck Fractures at the Experiment

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