A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative

E. Ivanova; A. Meleshkin; S. Skachilova; Yu. Elizarova; L. Singkh; D. Blinov; E. Blinova; E. Salyamova

doi:10.12737/9069

A COMPARATIVE STUDY OF TOXICITY AND THE SCALE OF ACTIVITY OF NEW N-SUBSTITUTED BENZAMIDE DERIVATIVE A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative

АА Аа

Published in Journal of New Medical Technologies · Volume 22, Issue 1 · Pages 16–19 · Rubric: Clinical Picture and Methods of Treatment. Functional and Instrumental Diagnostics. New Medicinal Forms

DOI: https://doi.org/10.12737/9069

Received: 13.03.2015 Accepted: 13.03.2015 Published: 13.03.2015 Language of publication: RUS

Authors

E. Ivanova

A. Meleshkin

S. Skachilova

Yu. Elizarova

et al.

L. Singkh

D. Blinov

E. Blinova

E. Salyamova

E. Ivanova

A. Meleshkin

S. Skachilova

Yu. Elizarova

L. Singkh

D. Blinov

E. Blinova

E. Salyamova

ABSTRACT

A promising search direction of modern scientists, involved in antiarrhythmic researchs, is the creation of substances that can suppress the repolarization phase of the action potential of myocardial cells. At the same time, the well-known domestic representative of this group of substances – the Nibentan – has a number of undesirable effects. To correct for these effects, the chemical compound the Nibentan with L-glutamic acid as the anion was created. In experi-ments on mice, it was found that the acute toxicity of the compound is N-substituted Benzamide derivative – Racemate Nibentan with L-glutamic acid is below 1.6 times at the intra-peritoneal injection in comparison with the acute toxicity structural analogue the Nibentan. Studied chemical compound in the range of doses from 1 to 5 % from DL50 suppresses reproduction acontinued disturbances of cardiac rhythm, which may serve as evidence of the ability of compounds to inhibit sodium ion currents through the membrane of cardiomyocytes. The compound of the Racemate Nibentan with L-glutamic acid also has a great therapeutic effect on aconitine arrhythmiac model in rats. On the model of transient ischemic arrhythmias a new compound Nibentan with comparable anti-arrhythmic activity in doses of 5 and 2.5 % from LD50, exceeds the reference product to prevent the formation of occlusion and reperfusion ventricular fibrillation in acute experience on cats. This work was supported by the project (project code - 2859) performed in Mordovia State N.P. Ogarev University under Government job and grant RFBR 14-04-31104.

KEYWORDS

antiarrhythmic medicine, aconitine arrhythmiac, occlusion and reperfusion arrhythmia, Nibentan compound, acute toxicity, activity

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GOST

Ivanova E., Meleshkin A., Skachilova S., Elizarova Y., Singkh L., Blinov D., Blinova E., Salyamova E. A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative // Journal of New Medical Technologies. 2015. no. 1. pp. 16-19. DOI: https://doi.org/10.12737/9069. (Date of access 01.10.2026).

MLA

E. Ivanova, Meleshkin A., Skachilova S., Elizarova Y., Singkh L., Blinov D., Blinova E., Salyamova E.. "A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative." Journal of New Medical Technologies 22.1 (2015): 16-19. DOI: https://doi.org/10.12737/9069.

APA

Ivanova E., Meleshkin A., Skachilova S., Elizarova Y., Singkh L., Blinov D., Blinova E., Salyamova E. (2015). A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative. Journal of New Medical Technologies, 22(1), 16-19. https://doi.org/10.12737/9069

Chicago

E. Ivanova, Meleshkin A., Skachilova S., Elizarova Y., Singkh L., Blinov D., Blinova E., Salyamova E.. "A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative." Journal of New Medical Technologies 22, no. 1 (2015): 16-19. https://doi.org/10.12737/9069.

WIKI

{{cite journal | author = Ivanova E., Meleshkin A., Skachilova S., Elizarova Y., Singkh L., Blinov D., Blinova E., Salyamova E. | title = A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative | journal = Journal of New Medical Technologies | year = 2015 | volume = 22 | issue = 1 | pages = 16-19 | doi = 10.12737/9069 }}

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A COMPARATIVE STUDY OF TOXICITY AND THE SCALE OF ACTIVITY OF NEW N-SUBSTITUTED BENZAMIDE DERIVATIVE A Comparative Study of Toxicity and the Scale of Activity of New N-Substituted Benzamide Derivative

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