Antidiabetic activity of derivatives of cyclic guanidine is one of the types of pharmacological activity, which attracts many researchers because it gives the possibility to create medicines for the treatment of diabetes. Derivatives of cyclic guanidino manifeste a wide range of biological and pharmacological activity, including antibacterial, antiparasitic, antihistamines, anticonvulsants, anti-inflammatory, antihypertensive, antitumor, antiherpesvirus and antiviral against hepatitis C and B. These substances are also antiserotonin; antithrombotic and antioxidant activities. In the present work the authors study the dependence between the level of hy-poglycemic activity and basic chemical structures of cyclic guanidine derivatives by method of mathematical statistics. They identified class N9-substituted 2,3-dihydro-imidazo[1,2-a] benzimidazole as the most promising in terms of possible compounds with high hypoglycemic activity. The described direction in this work on the search of antidiabetic drugs are the most promising to create the medicines for pharmacotherapy of diabetes of the second type. However, the authors emphasized that the search of hypoglycemic and antidiabetic funds in the future allows to significantly expand by new data on the genetic basis and molecular mechanisms of pathogenesis of diabetes of the second type.
mathematical statistics, median, hypoglycemic activity, cyclic guanidine, basic chemical structure.
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