This brief scientific review presents the main provisions of molecular-genetic theory of carcinogenesis. The review contains data on the presence of supra-cellular mechanisms of regulation of tissue homeostasis, which can be explained from the perspective of molecular-genetic approach, as well as data on the interpretation of the dominant theory of carcinogenesis based on other pathogenetic mechanisms that allows the author to con-tinue developing of tissue theory of carcinogenesis. Modern concepts of structural and functional characteristics of the microcirculatory channel are described. In the review the author provides convincing data, including its own data on the oxygen therapy effect (normobaric and hyperbaric oxygen therapy), on modulation of antioxi-dant activity of the tumor, on controlled differentiation of malignant cells by means of surgical method (by changing antegrade blood flow in the retrograde through vascular reverse). The importance of microcirculatory level of tissue homeostasis is defined. The review describes the significance of hyper-expression of this gene in the gene for factor vascular endothelial growth in carcinogenesis and forming a secondary tumor micro-circulation. The author gives pathogenetic substantiation of anti-VEGF therapy of malignant tumors by bevaci-zumab from the point of view of tissue approach to carcinogenesis. The main provisions of microcirculatory tissue theory of carcinogenesis are formulated.
microcirculation, oxygen therapy, vascular reverse, molecular-genetic theory of carcinogenesis, tissue theory of carcinogenesis, secondary microvascular bed, lipid peroxidation, antioxidant activity of tumors, VEGF, anti-VEGF therapy, bevacizumab, microcirculatory-tissue theory of carcinogenesis.
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