Surveyed 202 pregnant women with a diagnosis of influenza medium (n=154) and severe (n=48) severity. An algorithm for management of pregnant women with influenza, which is monitoring the level of markers of endothelial dysfunction; it is shown that its use in clinical practice can reduce the frequency of complications of pregnancy and childbirth and to improve perinatal outcomes. The results were statistically evaluate the relationship between indicators of pregnancy and childbirth, and the dynamics of the concentrations of markers of endothelial dysfunction has revealed the presence of stable relationships indicators (statistically significant correlation coefficients Spearman moderate strength). In particular, it is shown that the vascular endothelial factor concentration is negatively associated with the incidence of intrauterine growth retardation, preeclampsia, placental insufficiency, anemia and threatened premature delivery, polyhydramnios. The results of the study, indicating the high prognostic value of the levels of markers of endothelial dysfunction, allow us to propose the inclusion of estimates of these parameters in the algorithm of management of pregnant women with influenza for the timely appointment of preventive and diagnostic and treatment activities in order to reduce the frequency of complications of pregnancy and childbirth and improve perinatal outcomes. The obtained results allow to conclude that pregnant women with symptoms of ARI (influenza) shows the definition of the levels of markers of endothelial dysfunction, a survey is recommended during the first indications of the disease. It is reasonable assessment of markers of endothelial dysfunction in this category pregnant in the dynamics after 1-2 months after acute respiratory illness.
influenza, acute respiratory viral infection, markers of endothelial dysfunction, pregnancy complications.
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