employee
Russian Federation
employee
Moscow, Russian Federation
employee
Russian Federation
GRNTI 76.33 Гигиена и эпидемиология
GRNTI 76.03 Медико-биологические дисциплины
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
BBK 534 Общая диагностика
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
Purpose: On clinical examples to estimate a probable contribution of the postponed earlier external radiation of all body in the doses exceeding 1 Gy at development of multiple malignant neoplasms of different localization and a leukaemia. Material and methods: At 8 of 164 patients, it is long observed after the postponed acute radiation syndrome (ARS), multiple oncological diseases are revealed. Dynamics of consecutive forming of solid tumors at 2 patients and also malignant neoplasms and a myelodysplastic syndrome (MDS) with transformation in an acute leukamia at 1 patient is tracked. Observation duration – 31 years, 43 years and 32 years. Results: Availability of medical care to the patients who transferred ARS and high quality of its rendering at all stages (out-patient, stationary) allowed to reveal malignant neoplasms at early stages of development and to achieve an absolute recovery. However eventually at these patients development and other oncological diseases was observed. The given clinical observations allow to assume that at presented cases radiation acted on various stages of carcinogenesis, and its contribution to development of different oncological diseases in all patients was not identical. Conclusion: The analysis of clinical observations allows to assume that radiation contribution to genesis of various oncological diseases at the persons which underwent radiation in the doses causing development of ARS is various. Now in our country there are no approaches to quantitative assessment of a contribution of radiation effects to development of malignant neoplasms in each case. The patients who underwent acute single exposition in doses over 1 Gy have to be considered as having predisposition to development of multiple tumors in the remote terms. In this regard they for life need medical follow up for the purpose of early diagnostics and adequate treatment of the developing malignant neoplasms.
acute radiation syndrome, late period, neoplasms, radiation contribution assessment
1. Epidemiological studies of radiation and cancer. Annex A. UNSCAR, 2006. 350 p. [Epidemiological studies of radiation and cancer. Annex A. UNSCAR, 2006. 350 p. (In Russ.)].
2. Davydov MI, Gancev ShH. Onkologiya: uchebnik. M.: GEOTAR-Media, 2010. 920 s. [Davidov MI, Gancev ShH. Oncology: textbook. Moscow: GEOTAR-Media, 2010. 920 p. (In Russ.)].
3. Iwanaga M, Hsu W-L, Soda M, Takasaki Y, Tavara M, Joh T, et al. Risk of myelodysplastic syndromes in people exposed to ionizing radiation: A retrospective cohort study of Nagasaki atomic bomb survivors. J Clin Oncol. 2011;29(4):428. DOI:https://doi.org/10.1200/JCO.2010. 31.3080.
4. Gentile G, Mele A, Monarco B, Vitale A, Pulsoni A, Visani G, et al. Hepatitis B and C viruses, human T-cell lymphotropic virus types I and II, and leukemias: A case-control study. The Italian Leukemia Study Group. Cancer Epidemiology, Biomarkers and Prevention. 1996;5(3):227.
5. Mahale P, Torres HA, Kramer JR, Hwang LY, Li R, Brown EL, Engels EA. Hepatitis C virus infection and the risk of cancer among elderly US adults: A registry-based case-control study. Cancer. 2017 Apr 1;123(7):1202-1211. DOI:https://doi.org/10.1002/cncr.30559.
6. Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International head and neck cancer epidemiology consortium. J Natl Cancer Inst. 2007;99(10):777. DOI:https://doi.org/10.1093/jnci/djk179.
7. Smirnova IO. Fotostarenie kozhi i bazal'no-kletochnyy rak: rol' tuchnyh kletok. Klin med. 2005;7:55-58 [Smirnova IO. Photoaging of skin and basal and cellular cancer: role of mast cells. Klin med: 2005, 7, 55 (In Russ.)].
8. Kurdina MI, Vinogradova NN, Kolen'ko NG, Zaev SN. Opuholi kozhi i pervichno-mnozhestvennye zlokachestvennye novoobrazovaniya. Klin med. 2009;2:60. [Kurdina MI, Vinogradova NN, Kolenko NG, Zaev SN. Skin tumors and primary and multiple malignant neoplasms. Klin med. 2009;2:60-64. (In Russ.)].
9. Bushmanov AYu, Nadezhina NM, Nugis VYu, Galstyan IA. Mestnye luchevye porazheniya kozhi cheloveka: vozmozhnosti biologicheskoy indikacii dozy (analiticheskiy obzor). Medicinskaya radiologiya i radiacionnaya bezopasnost'. 2005;50(1):37-47. [Bushmanov AYu, Nadejina NM, Nugis VYu, Galstyan IA. Local radiation injuries of skin of the person: possibilities of biological indication of a dose (analytic review). Medical Radiology and Radiation Safety. 2005;50(1):37-47. (In Russ.)].
10. Kishikawa M, Koyama K, Iseki M, Kobuke T, Yonehara S, Soda M, et al. Histologic characteristics of skin cancer in Hiroshima and Nagasaki: background incidence and radiation effects. Int J Cancer. 2005 Nov 10;117(3):363. DOI:https://doi.org/10.1002/ijc.21156.
11. Little MP Risks associated with ionizing radiation environmental pollution and health. British Medical Bulletin. 2003;68(1):259. DOI:https://doi.org/10.1093/bmb/ldg031.
12. Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958-1998. Rad Res. 2007;168:1-64. DOI:https://doi.org/10.1667/RR0763.1.
13. Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuch K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res. 2003;160(4):381-407. DOI:https://doi.org/10.1667/rr3049.
14. Shimizu Y, Kato H, Schull WJ Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985: Part 2. Cancer mortality based on the recently revised doses (DS86) Radiat Res. 1990;121(2):120.
15. Kalistratova VS, Belyaev IK, Zhorova ES, Parfenova IM, Tischenko GS. Radiobiologiya inkorporirovannyh radionuklidov. M., 2016. 556 s. [Kalistratova VS, Belyaev IK, Jorova ES, Parfenova IM, Tischenko GS, Tsapkov MM Radiobiology of the Incorporated Radionuclides. M. 2016. 556 p. (In Russ.)].
16. Alyaev YuG, Grigoryan ZG, Levko AA. Dvustoronniy asinhronnyy rak pochek. Onkourologiya. 2010;6(2):14-21. [Alyaev YuG, Grigoryan ZG, Levko AA. Bilateral asynchronous cancer of kidneys. Oncourology. 2010;6(2):14-21. (In Russ.)]. DOI:https://doi.org/10.17650/1726-9776-2010-6-2-14-21.
17. Komarov MI, Poddubnaya IV Dvustoronniy rak pochek, etiologiya i patogenez. Rossiyskiy bioterapevticheskiy zhurnal. 2013;12(3):25-28. [Komarov MI, Poddubnaya IV. Bilateral cancer of kidneys, etiology and pathogenesis. Russian Biotherapeutic Journal. 2013;12(3):25-28. (In Russ.)].