ANTIVIRAL ACTIVITY OF HERBAL EXTRACTS AGAINST THE TICK BORNE ENCEPHALITIS VIRUS (LITERATURE REVIEW)
Rubrics: MICROBIOLOGY AND VIROLOGY
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Leading Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Clinical Research Assistant)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
5.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
6.
Institute of Traditional Medicine
(Research Officer)
Ulaanbaatar, Mongolia
Ulaanbaatar, Mongolia
7.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 93
to 99
Status:
Published
Received:
18.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
virus kleschevogo encefalita, ekstrakty trav, Terminalia chebula
Abstract (English):
Kleschevoy encefalit (KE) – shiroko izvestnoe virusnoe zabolevanie, kotoroe peredaetsya cherez ukusy iksodovyh kleschey. V tyazhelyh sluchayah KE privodit k invalidizacii ili gibeli bol'nogo. Vozbuditelem KE yavlyaetsya virus KE, otnosyaschiysya k semeystvu Flaviviridae. Nesmotrya na bol'shoe znachenie KE v patologii cheloveka, v nastoyaschee vremya edinstvennym sredstvom profilaktiki i lecheniya etogo zabolevaniya yavlyaetsya donorskiy immunoglobulin, kotoryy obladaet celym ryadom suschestvennyh nedostatkov. V dannoy rabote proanalizirovana sovremennaya literatura o vyyavlenii protivovirusnyh svoystv preparatov rastitel'nogo proishozhdeniya i ocenena vozmozhnost' ih ispol'zovaniya dlya poiska novyh lekarstv protiv virusa KE. Prakticheski vse opublikovannye raboty mozhno razdelit' na dva napravleniya issledovaniy – izuchenie cel'nyh ekstraktov rasteniy i izuchenie biologicheskoy aktivnosti ochischennyh komponentov ekstraktov. Pri etom vtoroy podhod inogda ispol'zuetsya v kachestve estestvennogo prodolzheniya pervogo. Naibolee informativnye rezul'taty mozhno poluchit' pri vypolnenii nekotoryh usloviy, naprimer, issleduya vodnye ekstrakty rasteniy ili ekstrakty, poluchennye s pomosch'yu organicheskih rastvoriteley. Pri etom neobhodimo frakcionirovanie ishodnyh preparatov s vyyavlennoy protivovirusnoy aktivnost'yu s posleduyuschey koncentraciey celevogo veschestva i identifikaciya protivovirusnogo agenta dlya polucheniya standartizovannyh preparatov s cel'yu provedeniya doklinicheskih ispytaniy na laboratornyh zhivotnyh i kul'turah kletok. Takoy podhod pozvolil vyyavit' tri veschestva – hebulievuyu kislotu, punikalagin i baykalein, obladayuschie neytralizuyuschey aktivnost'yu v otnoshenii flavivirusa Denge. V nastoyaschem soobschenii obsuzhdaetsya optimal'nyy algoritm poiska protivovirusnyh sredstv v rastitel'nyh preparatah i vozmozhnost' ispol'zovaniya etih veschestv protiv virusa KE.
Kleschevoy encefalit (KE) – shiroko izvestnoe virusnoe zabolevanie, kotoroe peredaetsya cherez ukusy iksodovyh kleschey. V tyazhelyh sluchayah KE privodit k invalidizacii ili gibeli bol'nogo. Vozbuditelem KE yavlyaetsya virus KE, otnosyaschiysya k semeystvu Flaviviridae. Nesmotrya na bol'shoe znachenie KE v patologii cheloveka, v nastoyaschee vremya edinstvennym sredstvom profilaktiki i lecheniya etogo zabolevaniya yavlyaetsya donorskiy immunoglobulin, kotoryy obladaet celym ryadom suschestvennyh nedostatkov. V dannoy rabote proanalizirovana sovremennaya literatura o vyyavlenii protivovirusnyh svoystv preparatov rastitel'nogo proishozhdeniya i ocenena vozmozhnost' ih ispol'zovaniya dlya poiska novyh lekarstv protiv virusa KE. Prakticheski vse opublikovannye raboty mozhno razdelit' na dva napravleniya issledovaniy – izuchenie cel'nyh ekstraktov rasteniy i izuchenie biologicheskoy aktivnosti ochischennyh komponentov ekstraktov. Pri etom vtoroy podhod inogda ispol'zuetsya v kachestve estestvennogo prodolzheniya pervogo. Naibolee informativnye rezul'taty mozhno poluchit' pri vypolnenii nekotoryh usloviy, naprimer, issleduya vodnye ekstrakty rasteniy ili ekstrakty, poluchennye s pomosch'yu organicheskih rastvoriteley. Pri etom neobhodimo frakcionirovanie ishodnyh preparatov s vyyavlennoy protivovirusnoy aktivnost'yu s posleduyuschey koncentraciey celevogo veschestva i identifikaciya protivovirusnogo agenta dlya polucheniya standartizovannyh preparatov s cel'yu provedeniya doklinicheskih ispytaniy na laboratornyh zhivotnyh i kul'turah kletok. Takoy podhod pozvolil vyyavit' tri veschestva – hebulievuyu kislotu, punikalagin i baykalein, obladayuschie neytralizuyuschey aktivnost'yu v otnoshenii flavivirusa Denge. V nastoyaschem soobschenii obsuzhdaetsya optimal'nyy algoritm poiska protivovirusnyh sredstv v rastitel'nyh preparatah i vozmozhnost' ispol'zovaniya etih veschestv protiv virusa KE.
Keywords:
virus kleschevogo encefalita, ekstrakty trav, Terminalia chebula
virus kleschevogo encefalita, ekstrakty trav, Terminalia chebula
1. Spislit_antivirusnaya aktivnost'
