Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Progesterone is a natural steroid hormone that has many functions in the organism, regulating the work of non-reproductive and reproductive tissues. The article describes the mechanism of hormone effects. The data about genomic and nongenomic effects of progesterone through intracellular and plasma membrane´s receptors are presented. Specific effects of progesterone in various tissues depend on the ratio of receptors and their coregulators. Progesterone is the main hormone of pregnancy; therefore a large section is devoted to its action in that period. The hormone functions include participation in the ovulation and implantation processes, decidual transformation of endometrial tissue, inhibition of uterine contractility, suppression of the mother immune system, the accumulation of nutrients for fetal growth, development of the mammary glands, co-operation in the development of the embryo tissues. Several mechanisms of preventing myometrial contractility and transition mechanism of maternal immune system to function in conditions of pregnancy are considered in detail. Besides the hormone role during pregnancy, the regulation of other important functions of the human body is described.
progesterone, mechanism of action, pregnancy
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