Bulletin physiology and pathology of respiration Bulletin physiology and pathology of respiration Бюллетень физиологии и патологии дыхания 1998-5029 12173 10.12737/20128 ОБЗОРЫ REVIEWS ОБЗОРЫ MODERN CONCEPTS OF PROGESTERONE ROLE (REVIEW) СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ ПРОГЕСТЕРОНА (ОБЗОР ЛИТЕРАТУРЫ) Довжикова Инна Викторовна Dovzhikova Inna Viktorovna dov_kova100@rambler.ru

доктор биологических наук;

doctor of sciences in biology;

 Луценко Михаил Тимофеевич Lutsenko Mikhail Timofeevich lucenkomt@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Дальневосточный научный центр физиологии и патологии дыхания RU Far Eastern Scientific Center of Physiology and Pathology of Respiration RU 15 06 2016 15 06 2016 1 60 94 104 https://naukaru.ru/en/nauka/article/12173/view

Прогестерон – естественный стероидный гормон, выполняющий в организме множество функций, регулирующих работу репродуктивных и нерепродуктивных тканей. В статье рассмотрен механизм эффектов гормона. Представлены данные о геномном и негеномном способах действия прогестерона, осуществляющегося через разные виды рецепторов: внутриклеточных и плазмомембранных. Специфические эффекты прогестерона в различных тканях зависят от набора рецепторов и их корегуляторов. Прогестерон является главным гормоном беременности, поэтому большой раздел обзора посвящен его действию в этот период. К функциям гормона относятся: участие в процессах овуляции и имплантации, преобразование эндометрия в децидуальную ткань, торможение сократимости матки, подавление иммунной системы матери, накопление питательных веществ в виде подкожного жира для обеспечения ими плода, рост и развитие молочных желез, участие в развитии тканей зародыша. Детально рассмотрены несколько эффектов предотвращения сократимости миометрия и механизм перехода иммунной системы матери на функционирование в условиях беременности. Помимо роли гормона во время беременности кратко описана регуляция других важных функций организма человека.

Progesterone is a natural steroid hormone that has many functions in the organism, regulating the work of non-reproductive and reproductive tissues. The article describes the mechanism of hormone effects. The data about genomic and nongenomic effects of progesterone through intracellular and plasma membrane´s receptors are presented. Specific effects of progesterone in various tissues depend on the ratio of receptors and their coregulators. Progesterone is the main hormone of pregnancy; therefore a large section is devoted to its action in that period. The hormone functions include participation in the ovulation and implantation processes, decidual transformation of endometrial tissue, inhibition of uterine contractility, suppression of the mother immune system, the accumulation of nutrients for fetal growth, development of the mammary glands, co-operation in the development of the embryo tissues. Several mechanisms of preventing myometrial contractility and transition mechanism of maternal immune system to function in conditions of pregnancy are considered in detail. Besides the hormone role during pregnancy, the regulation of other important functions of the human body is described.

прогестерон механизм действия беременность progesterone mechanism of action pregnancy

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