Non-lactational mastitis: characteristics of its course, diagnosis, and treatment (literature review)
Rubrics: REVIEWS
Abstract and keywords
Abstract (English):
Mastitis is an inflammatory breast disease, most often associated with lactation, but it can also occur in non–lactating women. Lactation mastitis is often a complication that occurs due to lactostasis during breastfeeding. Non-lactation mastitis is a multifactorial disease with a complex pathogenesis. The mechanisms of the disease development are not fully understood. The low incidence is largely due to insufficient diagnosis of the disease. Ultrasound, X-ray mammography, and magnetic resonance imaging are used in the diagnosis of non-lactation mastitis. Chronic non-lactation mastitis requires mandatory morphological confirmation, since it is clinically and instrumentally difficult to distinguish from malignant breast tumors. When choosing a biopsy method, preference should be given to core biopsy. Treatment of non-lactation mastitis includes an integrated approach using drug therapy and surgery, since monotherapy often leads to a recurrence of the disease in more than 50% of cases. Comprehensive treatment, as well as the correct choice of the type of surgical intervention and the time of its implementation, can reduce the risk of recurrence of non-lactation mastitis to 2-4%.

Keywords:
mammary gland, non-lactation mastitis, periductal mastitis, idiopathic granulomatous mastitis, diagnosis, treatment
References

1. Germanovich N.Yu., Schegol'kova T.A., Vishnevskaya G.A. i dr. Kompleksnoe lechenie hronicheskogo gnoynogo nelaktacionnogo mastita // Vysokotehnologicheskaya medicina. 2022. T. 9, № 4. S. 30-39.

2. Guseynov A.Z. Sovremennaya diagnostika i lechenie zabolevaniy molochnoy zhelezy. Monografiya. 2022, Tula: Izd-vo «TulGU». 264 s.

3. Costa M.O. V., Cubas-Vega N., López Del-Tejo P. et al. Non-lactational infectious mastitis in the Americas: a systematic review. Front Med (Lausanne). 2021;8:672513.

4. Mitchell K.B., Johnson H.M., Rodríguez J.M. et al. Academy of breastfeeding medicine. academy of breastfeeding medicine clinical protocol №36: the mastitis spectrum, Revised 2022. Breastfeed Med. 2022 May;17(5):360-376.

5. Wilson E., Woodd S.L., Benova L. Incidence of and risk factors for lactational mastitis: a systematic review. J. Hum Lact. 2020 Nov;36(4):673-686.

6. Bisenkov L.N., Ivanov V.G., Starkov I.I. i dr. Hirurgiya molochnoy zhelezy: Ruk-vo dlya vrachey. Sankt-Peterburg. Obschestvo s ogr. otvetstvennost'yu "Izd-vo "SpecLit", 2022. 151 s.

7. Jiao Y., Chang K., Jiang Y. et al. Identification of periductal mastitis and granulomatous lobular mastitis: a literature review. Ann Transl Med. 2023 Feb 15;11(3):158.

8. Dilaveri C., Degnim A., Lee C. et al. Idiopathic granulomatous mastitis. Breast J. 2024;2024:6693720.

9. Douglas P. Re-thinking benign inflammation of the lactating breast: Classification, prevention, and management. Womens Health (Lond). 2022 Jan-Dec;18:17455057221091349.

10. Zhang M., Pu D., Feng D. et al. Rare and complicated granulomatous lobular mastitis (2000–2023): a bibliometrics study and visualization analysis. Journal of inflammation research. 2024. R. 3709-3724.

11. Pavlova T.V., Shivilov E.V., Anichkina K.A. i dr. Protokovyy rak in situ v sochetanii s sindromom vospaleniya molochnoy zhelezy: redkoe klinicheskoe nablyudenie //Radiologiya–praktika. 2023. № 3. S. 60-74.

12. Peterson M.S., Gegios A.R., Elezaby M.A. et al. Breast imaging and intervention during pregnancy and lactation. Radiographics. 2023 Oct;43(10):e230014.

13. Wang X., He X., Liu J. et al. Immune pathogenesis of idiopathic granulomatous mastitis: from etiology toward therapeutic approaches. Frontiers in Immunology. 2024; 15:1295759.

14. Stachs A., Stubert J., Reimer T. et al. Benign breast disease in women. Dtsch Arztebl Int. 2019 Aug 09;116(33-34):565-574.

15. Gan Q., Ding Y., Wu Y. et al. Infections due to corynebacterium kroppenstedtii with focus on granulomatous lobular mastitis for tissue specificity, pathogenesis, bacteriologic workup, and treatment. Archives of pathology & laboratory medicine. 2025. Jan 13. doi:https://doi.org/10.5858/arpa.2024-0365-OA.

16. Xu H., Liu R., Lv Y. et al. Treatments for periductal mastitis: systematic review and meta-analysis. Breast Care (Basel). 2022 Feb;17(1):55-62.

17. Zhou F., Liu L., Wang F. et al. Periductal mastitis, a disease with distinct clinicopathological features from granulomatous lobular mastitis. Journal of inflammation research. 2024;17:3815-3823.

18. Pasynkov D.V., Merinov S.N., Pavlikova O.A. i dr. Mammograficheski opredelyaemye asimmetrii parenhimy molochnyh zhelez: prichiny i vozmozhnosti ih mammograficheskoy i ul'trazvukovoy differencial'noy diagnostiki // Acta Medica Eurasica. 2023. № 4. S. 55-68.

19. Serebryakova S.V., Shumakova T.A., Yuhno E.A. i dr. Vozmozhnosti MRT v differencial'noy diagnostike nelaktacionnogo mastita i raka //Medicinskaya vizualizaciya. 2023. T. 27, № 2. S. 36-52.

20. Schegol'kova T.A., Germanovich N.Yu., Stepanova Yu.A. i dr. Rak molochnoy zhelezy in situ na fone nelaktacionnogo mastita // Vysokotehnologicheskaya medicina. 2021. T. 8, № 3. S. 31-37.

21. Crepinsek M.A., Taylor E.A., Michener K. et al. Interventions for preventing mastitis after childbirth. Cochrane Database Syst Rev. 2020 Sep 29;9(9):CD007239.

22. Likhitmaskul T., Aroonsiriwattana S. Chronic idiopathic granulomatous mastitis in a male patient. The Bangkok medical journal. 2024; 20(1):33.

23. Kirk L.L., McDonald R.J., Clark A.X. Granulomatous mastitis following stereotactic core-needle biopsy: A case report. Journal of Clinical Imaging Science. 2024;14:40.

24. Febery A., Bennett I. Sonographic features of inflammatory conditions of the breast. Australias J Ultrasound Med. 2019 Aug;22(3):165-173.

Login or Create
* Forgot password?