Россия
Россия
Россия
На протяжении всей жизни человек неизбежно подвергается воздействию низких доз ионизирующего излучения (ИИ) как фонового, так и в рамках медицинского лечения и диагностики, в ходе профессиональной деятельности, авиаперелетов и др. Эффекты, оказываемые низкими дозами ИИ, и риски отдаленных последствий этого воздействия, сегодня все больше привлекают внимание исследователей. С одной стороны, ученые указывают на развитие неблагоприятных последствий, в частности, накопление двухцепочечных разрывов ДНК, с другой, существуют исследования, демонстрирующие развитие таких явлений, как гормезис и адаптивный ответ. На основании этого существует предположение, что в диапазоне низких доз радиации может иметь место нелинейная зависимость эффектов от дозы облучения т.е. эффект не пропорционален полученной дозе, что согласуется с пороговой концепцией. Данному направлению исследований сегодня посвящено множество научных трудов. Особое внимание привлекают эффекты, оказываемые низкими дозами ИИ на мезенхимальные стромальные клетки (МСК) человека, поскольку они являются регенеративным резервом организма. Благодаря способности к самоподдержанию МСК могут длительное время находиться в организме и подвергаться нескольким раундам облучения, накапливая в себе происходящие изменения и передавая их следующим поколениям клеток, поскольку обладают потенциями к дифференцировке. Таким образом, изменения, произошедшее в МСК, отражаются на организме человека в целом. На основании всего вышеизложенного можно сделать вывод, что изучение эффектов, оказываемых низкими дозами радиации на мезенхимальные стромальные клетки человека, на сегодняшний день является актуальным направлением исследований.
адаптивный ответ, геномная нестабильность, мезенхимальные стромальные клетки, радиочувствительность, эффекты низких доз радиации, радиационный гормезис, радиорезистентность, эффект свидетеля
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