сотрудник
Институт химической физики им. Н.Н. Семенова РАН (старший научный сотрудник)
сотрудник
Россия
сотрудник
Россия
В обзоре рассмотрены работы, представляющие экспериментальные данные по эмбритоксическим и тератогенным эффектам воздействия ионизирующего излучения у рыб данио (Danio rerio), являющихся удобным модельным объектом экспериментальной эмбриологии и радиационной биологии. Рассматриваются молекулярные механизмы, вовлеченные в ответ на действие ионизирующего излучения и определяющие уровень эмбриональной гибели, либо нарушения дальнейшего развития эмбрионов. Изложены данные об остром и хроническом с различной мощностью дозы воздействиях γ-излучения на эмбрионы различной стадии развития. Показано, что влияние γ-излучения на гибель и развитие эмбрионов рыб данио носит немонотонный характер, зависит как от условий облучения, так и от стадии эмбриогенеза. Результаты таких исследований крайне важны для понимания механизмов формирования радиационно-индуцированных биологических эффектов в эмбриогенезе позвоночных животных, включая человека, а также для разработки методов и подходов к оценке радиационного риска для развивающегося организма.
γ-излучение, данио, эмбриогенез, тератогенез, эмбриотоксические эффекты
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