The authors proposed the effective method of chemotherapy, which improves the efficiency of treatment of patients with locally common forms of breast cancer with extensive local or regional areas and the presence of edema of the breast tissue. This method consists of consecutive chemoembolization or chemoinfusion of thoracic arteries and the introduction of cytotoxic agents with subsequent radical radiotherapy. This method ensures a high level of local and systemic control of the disease due to the synergistic effects of radiation, chemotherapy, embolization, surgical treatment. Aggressive course of locally spread breast cancer (T4b,T4d), stages with the presence of edema, differences in the studies of various authors, the understanding of new mechanisms of development and progression of this disease - all this makes a fresh look at the possibilities of combination therapy. The analysis of the studies has shown that the combined chemotherapeutic effects with the use of chemoembolization/ chemoinfusion are safe and highly effective method of treatment of the patients with breast cancer. Modern radiation therapy in combination with chemoembolization may lead to reduced lesion, which makes possible radical removal of the tumor. This leads to a high survival rate over 5 years among patients with breast cancer. These patients have successfully completed a course of the planned treatment.
breast cancer, systemic intra-arterial chemotherapy, chemoembolization, chemoinfusion thoracic arteries, radical radiation therapy, the average fractionation.
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