UDK 61 Медицина. Охрана здоровья
Vitamin B12 deficiency is a common condition that can manifest with nonspecific clinical symptoms and, in severe cases, neurologic and hematologic abnormalities. Currently, vitamin B12 deficiency occurs most commonly due to malabsorption of food-associated cobalamin. Because lack of diagnosis can lead to potentially serious complications including spinal cord degeneration and pancytopenia, vitamin B12 deficiency should be diagnosed early and treated accordingly. Treatment for vitamin B12 deficiency is simple but can last a lifetime.
cobalamin, vitamin B12, vitamin B12 deficiency, pernicious anemia, B12 deficiency anemia.
1. Vorob'ev AI, editor. Rukovodstvo po gematologii: v 3 t. M.: "Niyudiamed"; 2005.
2. Rumyancev AG, Maschan AA, Zhukovskaya EV. Detskaya gematologiya. 2015.
3. Dolgov V.V., Lugovskaya S.A., Morozova V.T., Pochtar' M.E. Laboratornaya diagnostika anemiy. Moskva, Triada. 2009; 147 s. n.d.
4. Egorova M.O., Cvetaeva N.V., Suhacheva E.A., Komolova E.N. Prakticheskie rekomendacii po skriningovoy laboratornoy diagnostike anemii. Gematologiya i transfuziologiya. 2011; 56; 5: 24-36.
5. Klinicheskie rekomendacii - Vitamin B12 deficitnaya anemiya - 2021-2022-2023 (09.09.2021) - Utverzhdeny Minzdrava RF.
6. Anemii. Metodicheskoe posobie dlya vrachey. L.B. Filatov/ - g. Ekaterinburg, 2006 god.
7. Anemii. N.A. Alekseev/ - SPb: Gippokrat, 2004 god.
8. Michael Whitehead V. Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol 2006; 134: 125-36.
9. Kozyraki R, Kristiansen M, Silahtaroglu A, Hansen C, Jacobsen C, Tommerup N, et al. The human intrinsic factor-vitamin B12 receptor, cubilin: Molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 1998; 91: 3593 - 600.
10. Tanner SM, Li Z, Perko JD, Oner C, Cetin M, Altay C, et al. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Proc Natl Acad Sci 2005; 102: 4130-3.
11. Maykl Dzh. Shipton, Dzhekko Tachil «Deficit vitamina B12 - perspektiva 21 veka» s. 24.
12. Milli Rayan-Harshman, Valid Al'duri « Vitamin B12 i zdorov'e» s.5-6.
13. Dzh.H. Martens, H. Brag, M. Dzh. Uorren, D. Dzhan «Mikrobiologicheskoe proizvodstvo vitamina B12» s.74.
14. Robert O., Devid L. Braun «Deficit vitamina B12» s.81.
