The authors studied the effect of insulin on a histological picture of rats’ brain on the background of immobilization and after swimming to exhaustion. The insulin injection in the background immobilization leads to expansion of vessels, plethora, sludge, aggregation of red blood cells, depletion glycogen, necrobiotic changes, proliferation of glial elements. The insulin injection after swimming stress leads to more pronounced plethora, expressed perivascular edema, stasis, aggregation of red blood cells, depletion glycogen astrocytic cells, lysis of nuclei and cells, the formation of cell-shading, in a number of fields of view of the empty cells, the appearance of focal areas of necrosis and hemorrhage. The authors found the regional differences in the reaction of glucose with different kinds of stress. The blood glucose level, flowing from the parenchymatous organs, brain and heart were normal and elevated, despite hypoglycemic blood from the tail vein. Swimming stress significantly decreased a glycemic blood, flowing from the liver and heart, which can be explain by the depletion of the reserves of glycogen in the face of intense muscular exercise. The insulin injection in conditions of stress leads to an aggravation of disorders of microcirculation, which allows to using the stress models to study hormone action in conditions of high sensitivity.
morphological changes in the brain of the Wistar rats, insulin, brain ischemia, stress, immobilization, swimming to exhaustion.
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