Purpose of this research is to study the physiological correlates of adaptive reactions of the organism on leukocyte formula blood using the algorithm of L.H. Garkavi in young patients with mild arterial hypertension and overweight. Materials and methods. The study included the data of comprehensive survey of 56 young men (16-26 years, mean 18.6+/-0.6 years) with mild hypertension, with overweight and obesity (BMI from 25.0 to 34.8 kg/m²). In addition to laboratory studies, multifunctional monitoring of ECG+AD (Incart, SPb) in outpa-tients was carried out for all young men. Results. There are all types of adaptive reaction in the studied group, excepting a “stress reaction”. 8 ado-lescents (14,3%) had a leukocyte distribution corresponding to a “training reaction”, 39,3% young men demon-strated a “reaction of quiet activation”, 25,0% – a “reaction of increased activation” and 21,4% of adolescents had an “over activation”. Average diastolic blood pressure in the “quiet activation” and “over activation” groups a night was higher (62,4±1,8 mm Hg, t=2,0; df=17, P=0,04 and 63,3±2,2 mm Hg, t=2,1; df=15, P=0,04) than in the “training” group (57,3±1,4 mm Hg). Night diastolic blood pressure decline in “training”, “quiet activation” and “increased activation” groups was 22,8%, 20,3% и 21,0% to be due to a tendency to excessive night decrease of diastolic blood pressure («over-dippers»).Young men with reaction of the increased activation had lower spectral power of very low, low and high frequency band in the day-time than in the “training” group. Significant correlations were obtained between systolic blood pressure value a day and night, spectral analysis of heart rate variability results and white blood parameters. Conclusion. The revealed physiological correlates allow to recommend the method of adap-tive reactions by L.H. Garkavi to assess the functional capacity of young people with mild hypertension and overweight.
adaptation, arterial hypertension, adolescents, overweight.
1. Averkina N.A., Filatova E.G. Psikhologicheskie faktory pri khronicheskoy boli. Zhurnal nev-rologii i psikhiatrii. 2000. № 12. S. 21-27.
2. Baevskiy R.M., Ivanov G.G. Variabel´nost´ serdechnogo ritma: teoreticheskie aspekty i voz-mozhnosti klinicheskogo primeneniya. M.: Meditsina. 2000. 295 s.
3. Brazhenko N. A., Brazhenko O. N., Trofimov V. I. Adaptatsionnye reaktsii organizma i puti po-vysheniya effektivnosti lecheniya v sovremennykh usloviyakh. Novye Sankt-Peterburgskie vrachebnye ve-domosti. 2002. № 2. S. 49-53.
4. Butrova, S.A., Plokhaya A.A. Lechenie ozhireniya: sovremennye aspekty. Rus.med.zhurn. 2001. №24. S. 1140-1146.
5. Venevtseva Yu.L. Otsenka funktsional´nogo sostoyaniya yunykh sportsmenov s EKG-sindromom ran-ney repolyarizatsii zheludochkov serdtsa: avtoref. dis. … kand.med. nauk. Moskva, 1991. 24 s.
6. Venevtseva Yu.L., Mel´nikov A.Kh., Korneeva L.N. Pokazateli variabel´nosti ritma serdtsa v otsenke urovnya adaptatsii lits molodogo vozrasta. Vestnik aritmologii. 2000. №16. S. 53-55.
7. Garkavi L.Kh., Kvakina E.B., Ukolova M.A. Adaptatsionnye reaktsii i rezistentnost´ organiz-ma, 3-e izdanie dopolnennoe. Rostov-na-Donu, 1990. 224 s.
8. Garkavi L.Kh. Aktivatsionnaya terapiya. Rostov n/D: Izd-vo Rost.un-ta, 2006. 256 s.
9. Derkach Z.V. Adaptatsionnye protsessy pri khronicheskoy bolezni pochek. Vestnik Rossiyskoy voenno-meditsinskoy akademii. 2013. № 2(42). S. 40-43.
10. Faktory riska serdechno-sosudistykh zabolevaniy u podrostkov s arterial´noy gipertenziey / Kislyak O.A., Storozhakov G.I., Petrova E.V. [i dr.]. Pediatriya. 2003. №2. S.16-20.
11. Natsional´nye rekomendatsii Vserossiyskogo nauchnogo obshchestva kardiologov po kardiova-skulyarnoy profilaktike. Kardiovaskulyarnaya terapiya i profilaktika. Prilozhenie № 2. 2011. T. 10. № 6. S. 64.
12. Novikov D.K., Novikova V.I. Otsenka immunnogo statusa. Moskva-Vitebsk. 1996. 281 s.
13. Sudakov K.V. Informatsionnye svoystva funktsional´nykh sistem: teoreticheskie aspekty. Vestnik RAMN. M. 1997. №12. S. 4-19.
14. PREDIMED Study Investigators. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study / Babio N., Ibarrola-Jurado N., Bulló M., [et al.]. PLoS One. 2013. 8(3). R. 583-584.
15. Caballero B, Clay T, Davis SM Pathways: a school-based, randomized controlled trial for the preven-tion of obesity in American Indian schoolchildren. Am J Clin Nutr. 2003. 78(5). R. 1030-1038.
16. Dickinson C.J. The determinants of long-term blood pressure stability: control of trough blood pres-sure during sleep. J Hypertens. 1998. 16(7). P. 907-912.
17. The associations of total and differential white blood cell counts with obesity, hypertension, dyslipi-demia and glucose intolerance in a Korean population / Kim D.J., Noh J.H., Lee B.W. [et al.]. Journal of Ko-rean Medical Science. 2008. 23(2). R.193-198.
18. Obesity is associated with acute inflammation in a sample of adolescents / Reyes M., Quintanilla C., Burrows R. [et al.]. Pediatr Diabetes. 2014. 17. R. 121-129.
19. Severely obese adolescents and adults exhibit a different association of circulating levels of adipo-kines and leukocyte expression of the related receptors with insulin resistance / Rigamonti A.E., Agosti F., De Col A. [et al.]. Int J Endocrinol. 2013. №21. R. 5659-5667.
20. EVEREST trial investigators. Predictive value of low relative lymphocyte count in patients hospita-lized for heart failure with reduced ejection fraction: insights from the EVEREST trial / Vaduganathan M., Am-brosy A.P., Greene S.J. [et al.]. Circ Heart Fail. 2012. 5(6). R. 750-758.
