Saint-Petersburg State University, Saint-Petersburg, Russia
GRNTI 76.33 Гигиена и эпидемиология
GRNTI 76.03 Медико-биологические дисциплины
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
BBK 534 Общая диагностика
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
In connection with the increase in the average age of the world's population, the problem of preventing premature aging and the treatment of age-related diseases is coming to the fore. The main direction in the implementation of this goal is to influence the key molecular mechanisms of aging in order to suppress pathological processes and activate the defense systems of the cell and the body as a whole. In order to solve this daunting task, it is necessary to have in the arsenal not only various means of intervention in the aging process, but also diagnostic methods that would allow to fully verify these processes and evaluate the effectiveness of medical interventions.
nuclear cardiology, radionuclide diagnostics, age changes, cardiovascular system, positron emission tomography
1. Moskalev A.A., Shaposhnikov M.V., Solov'ev I.A. Issledovanie geroprotektornyh svoystv ingibitorov aktivnosti svyazannyh so stareniem signal'nyh kaskadov na model'nyh organizmah // Med. Vest. Sev. Kav. 2017. 12. S. 342-347. DOIhttps://doi.org/10.14300/mnnc.2017.12090.
2. Laurent S, Boutouyrie P, Guimarães Cunha P, Lacolley P, Nilsson PM. Concept of Extremes in Vascular Aging From Early Vascular Aging to Supernormal Vascular Aging // Hypertension. 2019. 74. P. 218-228. DOI:https://doi.org/10.1161/HYPERTENSIONAHA.119.12655.
3. Lishmanov Yu.B., Zavadovskiy K.V., Efimova I.Yu., Krivonogov N.G., Efimova I.Yu., Vesnina Zh.V., Sazonova S.I., Saushkina Yu.V., Saushkin V.V., Il'yushenkova Yu.N., Gulya M.O., Peshkin Ya.A., Mochula A.V. Vozmozhnosti yadernoy mediciny v diagnostike serdechno-sosudistyh zabolevaniy // Sibirskiy zhurnal klinicheskoy i eksperimental'noy mediciny. 2015. 30(2). S. 21-29. https://doi.org/10.29001/2073-8552-2015-30-2-21-29.
4. Heron M. Deaths: leading causes for 2011 // Natl Vital Stat Rep. 2015. 64. P. 1-96.
5. Plohova E.V., Akasheva D.U., Tkacheva O.N., Strazhesko I.D., Dudinskaya E.N., Kruglikova A.S., Pyhtina V.S., Agal'cov M.V., Sharashkina N.V., Brailova N.V., Skvorcov D.A., Boycov S.A. Vozrastnoe remodelirovanie miokarda levogo zheludochka: est' li svyaz' s kletochnym stareniem? // Kardiovaskulyarnaya terapiya i profilaktika. 2015. 14(2). S. 52-57. http://dx.doi.org/10.15829/1728-8800-2015-2-52-57.
6. Cuspidi C, Facchetti R, Sala C et al. Normal values of left-ventricular mass: echocardiographic findings from the PAMELA study // J Hypertens. 2012. 30(5). P. 997-1003. DOI:https://doi.org/10.1097/HJH.0b013e328352ac39.
7. Leibowitz D, Gilon D. Echocardiography and the Aging Heart // Current Cardiovascular Imaging Reports. 2012. 5(6). P. 501-506.
8. Shock NW, Greulich RC, Andres RA, et al. Normal human aging: the Baltimore Longitudinal Study of Aging. Bethesda, MD: NIH Pub No 84-2450; 1984.
9. Mendes AB, Ferro M, Rodrigues B, et al. Quantification of left ventricular myocardial collagen system in children, young adults, and the elderly // Medicina (B Aires). 2012. 72(3). P. 216-20. PMID: 22763158.
10. Blagova O.V., Nedostup A.V., Sedov V.P., Kogan E.A., Pasha S.P., Gagarina N.V., Alieva I.N., Sedov A.V., Caregorodcev D.A., Kulikova V.A., Shepeleva N.E., Sarkisova N.D. Klinicheskie maski amiloidoza s porazheniem serdca: osobennosti diagnostiki na sovremennom etape // Rossiyskiy kardiologicheskiy zhurnal. 2017. (2): S. 68-79. https://doi.org/10.15829/1560-4071-2017-2-68-79.
11. Damy T, Mohty D, Deux JF, et al. Senile systemic amyloidosis: Definition, diagnosis, why thinking about? // Presse Med. 2013. 42(6 Pt 1). P. 1003-14. doi:https://doi.org/10.1016/j.lpm.2013.03.004.
12. Groznova O.S., Miklashevich I.M., Voinova V.Yu., Shkol'nikova M.A., Tkacheva O.N., Dudinskaya E.N., Kovalev I.A. Biomarkery rannego serdechno-sosudistogo stareniya // Ros vestn perinatol i pediatr 2019. 64:(4). S. 11-18. DOI:https://doi.org/10.21508/1027-4065- 2019-64-4-11-28.
13. Strazhesko I.D., Akasheva D.U., Dudinskaya E.N., Tkacheva O.N. Starenie sosudov: osnovnye priznaki i mehanizmy // Kardiovaskulyarnaya terapiya i profilaktika, 2012. 11(4). S. 93-100. https://doi.org/10.15829/1728-8800-2012-4-93-100.
14. Cunha PG, Olsen MH Chapter 24. Vascular Aging and Cardiovascular Disease. In: Nilsson PM, Olsen MH, Laurent S, eds. Early Vascular Aging (EVA). New Directions in Cardiovascular Protection // Academic Press. 2015. P. 261-271. DOIhttps://doi.org/10.1016/B978-0-12-801387-8.00025-9.
15. Tesauro M, Mauriello A, Rovella V et al. Arterial ageing: from endothelial dysfunction to vascular calcification // J. Intern. Med. 2017. 281(5). P. 471-482. doi:https://doi.org/10.1111/joim.12605.
16. Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A. et al. Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angio- genesis // Circ Res 2015. 117(4). P. 333-345. DOI:https://doi.org/10.1161/CIR- CRESAHA.117.305875
17. Sohn EH, Flamme-Wiese MJ, Whitmore SS, Wang K, Tucker BA, Mullins R.F. Loss of CD34 expression in aging human choriocapillaris endothelial cells // PLoS One 2014. 9(1). e86538. DOI:https://doi.org/10.1371/journal.pone.0086538.
18. Anthony J. Donato, Daniel R. Machin, Lisa A. Lesniewski. Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease // Circ Res. 2018. 123. P. 825-848. DOI:https://doi.org/10.1161/CIRCRESAHA.118.312563.
19. Laurent S, Boutouyrie P. Arterial Stiffness and Hypertension in the Elderly // Front. Cardiovasc. Med. 2020. 7:544302. doi:https://doi.org/10.3389/fcvm.2020.544302.
20. Ansheles A.A., Sergienko I.V., Sergienko V.B. Sovremennoe sostoyanie i perspektivnye tehnologii radionuklidnoy diagnostiki v kardiologii // Kardiologiya. 2018. 58(6). S. 61-69. DOI:https://doi.org/10.18087/cardio.2018.6.10134.
21. Cheng S, Xanthakis V, Sullivan LM, et al. Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course: Longitudinal Observations from the Framingham Heart Study // Circulation. 2010. 122(6). P. 570-578. doi:https://doi.org/10.1161/CIRCULATIONAHA.110.937821.
22. Pierdomenico SD, Di Nicola M, Pierdomenico AM, et al. Cardiovascular risk in subjects with left ventricular concentric remodeling at baseline examination: a meta-analysis // J. Hum. Hypertens. 2011. 25(10). P. 585-91. DOI:https://doi.org/10.1038/jhh.2011.24.
23. Carrick-Ranson G, Hastings JL, Bhella PS, et al. Effect of healthy aging on left ventricular relaxation and diastolic suction // Am. J. Physiol. Heart. Circ. Physiol. 2012. 1. 303(3). P. 15-22. DOI:https://doi.org/10.1152/ajpheart.00142.2012.
24. John Eng, Robyn L. McClelland, Antoinette S. Gomes, et al. Adverse left Ventricular remodeling and age assessed with cardiac Mr imaging: The Multi-Ethnic Study of Atherosclerosis // Radiology. 2016. 278(3). P. 714-722. https://doi.org/10.1148/radiol.2015150982.
25. Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’ // Eur Heart J. 2010. 31(19). P. 2338-2350.
26. AlGhatrif M, Strait JB, Morrell CH, et al. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging // Hypertension. 2013. 62(5). P. 934-941. DOI:https://doi.org/10.1161/HYPERTENSIONAHA.113.01445.
27. Said MA, Eppinga RN, Lipsic E et al. Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality // J Am Heart Assoc. 2018. 7(2). URL: https://doi.org/10.1161 /JAHA.117.007621.
28. Lassale C, David Batty G, Steptoe A, Cadar D, Akbaraly TN, Kivimäki M, Zaninotto P. Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging // J Gerontol A Biol Sci Med Sci. 2019. 74(2). P. 195-203. https://doi.org/10.1093/gerona/gly028.
29. Ling LH., Kistler PM., EllimsAH., Iles LM., Lee G., Hughes GL., Kalman JM., Kaye DM., Taylor AJ. Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction // J. Am. Coll. Cardiol. 2012. 60. P. 2402-2408. DOIhttps://doi.org/10.1016/j.jacc.2012.07.065.
30. Bekmurzinova F.K., Ospanov O.B., Akil'zhanova A.R., Kozhamkulov U.A., Rahimova S.E. Ocenka izmeneniya dliny telomer hromosom kak kriteriy prodolzhitel'nosti zhizni v bariatricheskoy praktike // Ozhirenie i metabolizm. 2020. 17(2). C. 125-129. https://doi.org /10.14341/omet10331.
31. Bressler J, Franceschini N, Demerath EW et al. Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study // BMC Med Genet. 2015. 16. P. 52. DOI:https://doi.org/10.1186/s12881-015-0194-x.
32. Nacional'noe rukovodstvo po radionuklidnoy diagnostike 2010. - T. 2. - 418 s. / pod red. Yu.B. Lishmanova, V.I. Chernova. - V 2-h t. - Tomsk : ISBN 980-5-93629-427-3.
33. A. Freund. Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks // Cell Systems. 2019. 86. P. 172-181. https://doi.org /10.1016/j.cels.2019.02.005.
34. Sergienko V.B., Tereschenko S.N., Ansheles A.A., Zhirov I.V., Safiullina A.A. Radionuklidnye metody v diagnostike amiloidoza serdca // Racional'naya farmakoterapiya v kardiologii 2018. 14(1). C. 94-100. DOI:https://doi.org/10.20996/1819-6446-2018-14-1-94-100.
35. Sergienko V.B., Ansheles A.A. Radionuklidnaya diagnostika v kardiologii. V: Chazov E.I., red. Rukovodstvo po kardiologii. Tom 1. Moskva: Praktika. 2014. C. 571-612.
36. Moghbel M, Al-Zaghal A, Werner TJ, Constantinescu CM, Høilund-Carlsen PF, Alavi A. The role of pet in evaluating atherosclerosis: a critical review // Semin. Nucl. Med. 2018. 48(6). P. 488-497. DOI:https://doi.org/10.1053/j.sem- nuclmed.2018.07.001.
37. Karpova N.Yu., Rashid M.A., Chipigina N.S. i dr. Kal'cinirovannyy aortal'nyy stenoz: izvestnye fakty i perspektivnye issledovaniya // Klinicist. 2020. 14(1-2). C. 34-41. DOI:https://doi.org/10.17650/1818-8338-2020-14-1-2-34-41.
38. Ansheles A.A., Schigoleva Ya.V., Sergienko I.V., Tereschenko S.N. Osobennosti perfuzii i simpaticheskoy innervacii miokarda po dannym odnofotonnoy emissionnoy komp'yuternoy tomografii u pacientov s gipertroficheskoy kardiomiopatiey // Kardiologicheskiy Vestnik. 2016. 11(1). S. 24-33.
39. Chapman J, Fielder E, Passos JF. Mitochondrial dysfunction and cell senescence: deciphering a complex relationship // FEBS Lett. 2019. 593. P. 1566-1579. DOI:https://doi.org/10.1002/1873-3468.13498.
40. Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Mitochondria in cell senescence: is mitophagy the weakest link? // EBio Medicine. 2017. 21. P. 7-13. DOI:https://doi.org/10.1016/j.ebiom.2017.03.020.
41. Safee ZM, Baark F, Waters ECT, et al. Detection of anthracycline induced cardiotoxicity using perfusioncorrected (99m)Tc sestamibi SPECT // Sci Rep. 2019. 9(1). P. 216. doihttps://doi.org/10.1038/s41598018367215.
42. Ansheles A.A., Sergienko I.V., Prus Yu.A., Sergienko V.B. Radionuklidnaya diagnostika kardiotoksichnosti, inducirovannoy himioterapiey // Kardiovaskulyarnaya terapiya i profilaktika. 2021. 20(2). C. 25-37. doihttps://doi.org/10.15829/1728880020212537.
43. Ferrucci L, Gonzalez-Freire M, Fabbri E, Simonsick E, Tanaka T, Moore Z, Salimi S, Sierra F, de Cabo R. Measuring biological aging in humans: a quest // Aging Cell. 2020. 19. e13080. DOI:https://doi.org/10.1111/acel.13080.
44. Nilsson MI, Tarnopolsky MA. Mitochondria and aging-the role of exercise as a countermeasure // Biology. 2019. 8. P. 40. DOI:https://doi.org/10.3390/biology8020040.
45. Moro L. Mitochondrial dysfunction in aging and cancer // J. Clin. Med. 2019. 8. P. 1983. DOI:https://doi.org/10.3390/jcm8111983.
46. Sergienko V.B. Sovremennye vozmozhnosti radionuklidnoy molekulyarnoy vizualizacii ateroskleroza // Ateroskleroz i dislipidemii. 2016. 4(25). C. 5-13.
47. Proshkina E.N., Solov'ev I.A., Shaposhnikov M.V., Moskalev A.A. Klyuchevye molekulyarnye mehanizmy stareniya, biomarkery i potencial'nye intervencii // Molekulyarnaya biologiya. 2020. 54 (6). S. 883-921. DOI:https://doi.org/10.31857/S0026898420060099.
