The author has analyzed the lipid profile blood in 30 patients with high activity of rheumatoid arthritis. The main cause of death of patients with rheumatoid arthritis is pathology of the cardiovascular system, an important role in the development of which is atherosclerosis and complications associated with its develop-ment. Currently, similarity of mechanisms of atherosclerosis and rheumatoid arthritis is proven. There are many studies demonstrating pathogenetic unity of these diseases. Both of these diseases have immuno-inflammatory character that accounts for their close relationship and opens new opportunities therapeutic. A number of studies have shown that the development and course of rheumatoid arthritis is associated with changes in the blood lipid spectrum, characterized by high atherogenicity. In this case, adequate anti-inflammatory therapy leads not only to decrease in the activity of rheumatoid arthritis, but also to reduce the coefficient of atherogenicity. The greatest contribution was made by the elevated levels of total and low-density lipoprotein cholesterol, which is associated with a high atherogenicity and increased cardiovascular risk.
rheumatoid arthritis, atherosclerosis, cytokines, lipid profile blood, high atherogenicity.
1. Anichkov D. A., Shostak N. A. Revmatoidnyy artrit i serdechno-sosudistyy risk: perspektivy primeneniya statinov. Ratsional´naya Farmakoterapiya v Kardiologii. 2005. №3. S. 47-53.
2. Arabidze G.G. Klinicheskaya immunologiyaateroskleroza - ot teoriik praktike. Ateroskleroz i dislipidemii. 2013. №1. S. 4-19.
3. Kardiologiya: natsional´noe rukovodstvo / pod red.Yu. N.Belenkova, R. G.Oganovoy. M.: GEO-TAR-Media, 2011. S. 603-611.NAUChN
4. Revmatologiya: natsional´noe rukovodstvo / pod red. E.L. Nasonova, V.A. Nasonovoy. M. : GEO-TAR-Media, 2010. S. 290-331, 647-660.
5. Novikova D.S., Popkova T.V., Nasonov E.L. Snizhenie kardiovaskulyarnogo riska pri revmato-idnom artrite: dvoynaya pol´za statinov. Nauchno-prakticheskaya revmatologiya. 2010. №6. S. 61-71.
6. Novikov A.A., Aleksandrova E. N., Diatroptova M.A., Nasonov E.L. Rol´ tsitokinov v patoge-neze revmatoidnogo artrita. Nauchno-prakticheskaya revmatologiya. 2010. №2. S. 71-82.
7. Popkova T.V., Novikova D.S., Lineva O.G., Novikov A.A., Aleksandrova E.N., Nasonov E.L. Vliyanie rituksimaba na sistemu transporta kholestrina krovi u bol´nykh revmatoidnym artritom. Nauchno-prakticheskaya revmatologiya. 2010. №4. S. 26-31.
8. Popkova T.V., Novikova D.S., Nasonov E.L. Ingibitory faktora nekroza opukholi α i risk serdechno-sosudistykh oslozhneniy pri revmatoidnom artrite. Sovremennaya revmatologiya. 2012. № 4. S. 30-39.
9. Popkova T.V., Novikova D.S., Nasonov E.L. Interleykin 6 i serdechno-sosudistaya patologiya pri revmatoidnom artrite. Nauchno-prakticheskaya revmatologiya. 2011. № 4. S. 64-72.
10. Popkova T.V., Gerasimova E.V., Novikova D.S., Nasonov E.L. Metotreksat i risk serdechno-sosudistykh oslozhneniy pri revmatoidnom artrite //Nauchno-prakticheskaya revmatologiya. 2012. № 50(6). S.70-79.
11. Popkova T.V., Novikova D.S., Nasonov E.L. Rekomendatsii po snizheniyu kardiovaskulyarnogo riska u patsientov s vospalitel´nymi artritami (po materialam rekomendatsiy Evropeyskoy antirevmaticheskoy ligi). Sovremennaya revmatologiya. 2010. №1. S. 7-11.
12. Popkova T.V., Novikova D.S., Pisarev V.V., Mach E.S., Nasonov E.L. Faktory riska kardiova-skulyarnykh zabolevaniy pri revmatoidnom artrite. Nauchno-prakticheskaya revmatologiya. 2009. №3. S. 4-11.
13. Sizikov A.E., Tuzikov F.V., Tuzikova N.A., Galimov R.V., Konenkova L.P., Gertsog O.A., Kozlov V.A. Osobennosti narusheniy lipidnogo obmena u bol´nykh revmatoidnym artritom. Nauchno-prakticheskaya revmatologiya. 2009. №2. S.23-30.
14. Sorotskaya V.N. Rasprostranennost´ i prichiny letal´nykh iskhodov revmaticheskikh zabo-levaniy na modeli Tul´skoy oblasti: dissertatsiya na soiskanie uchenoy stepeni doktora nauk. M., 2005. 228 s.
15. Tutunov V.S., Zubareva M.Yu., Malyshev P.P., Kukharchuk V.V. Statiny v revmatologii. Ate-roskleroz i dislipidemii. 2011. №2. S. 43-48.
16. Udachkina E.V., Novikova D.S., Popkova T.V., Nasonov E.. Rol´ interleykina-6 v razvitii ate-roskleroza pri revmatoidnom artrite. Sovremennaya revmatologiya. 2013. №3. S. 25-32.
17. Ozbalkan Zeynep, Efe Cumali, Cesur Mustafa, Ertek Sibel, Nasiroglu Narin, Berneis Kaspar, Rizzo Manfredi. Novye dannye o svyazi revmatoidnogo artrita i ateroskleroza. Ateroskleroz i dislipide-mii. 2013. №4. S. 4-11.
