SARS-COV-2: A NEW AUTOIMMUNE PATHOLOGY OR A STEP TOWARD DECIPHERING THE NATURE OF SYSTEMIC DISEASES?
Rubrics: DISCUSSION
Authors:
1.
Tula State University
(medicinskiy institut, professor)
Tula, Tula, Russian Federation
Tula, Tula, Russian Federation
Type:
Article
Pages:
from 24
to 26
Status:
Published
Received:
18.06.2020
Accepted:
18.06.2020
Published:
18.06.2020
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
coronavirus, systemic connective tissue diseases, cytokines, vasculitis, hyperimmune reaction.
Abstract (English):
The Cause of death in SARS-CoV-2 patients is a hyperimmune reaction to the pathogen that resembles a systemic rheumatological pathology, namely, severe lightning - fast variants of its course with adverse outcomes, for example, cata-strophic antiphospholipid syndrome, granulomatosis with polyangiitis with lung lesions, acute systemic lupus erythematosus with polyserositis, hemorrhagic alveolitis, and other multi-organ lesions. Such forms of the disease are rare, but they are united by a special uncontrolled production of molecules that potentiate inflammation, in such quantities that they lose their protective and destructive functions. The basis of organ lesions may be vasculitis of vessels of the microcirculatory bed. Studying the influence of SARS-CoV-2 on the development of a lightning-fast fatal hyperimmune reaction can clarify the etiopathogenesis of systemic rheumatic diseases.
The Cause of death in SARS-CoV-2 patients is a hyperimmune reaction to the pathogen that resembles a systemic rheumatological pathology, namely, severe lightning - fast variants of its course with adverse outcomes, for example, cata-strophic antiphospholipid syndrome, granulomatosis with polyangiitis with lung lesions, acute systemic lupus erythematosus with polyserositis, hemorrhagic alveolitis, and other multi-organ lesions. Such forms of the disease are rare, but they are united by a special uncontrolled production of molecules that potentiate inflammation, in such quantities that they lose their protective and destructive functions. The basis of organ lesions may be vasculitis of vessels of the microcirculatory bed. Studying the influence of SARS-CoV-2 on the development of a lightning-fast fatal hyperimmune reaction can clarify the etiopathogenesis of systemic rheumatic diseases.
Keywords:
coronavirus, systemic connective tissue diseases, cytokines, vasculitis, hyperimmune reaction.
coronavirus, systemic connective tissue diseases, cytokines, vasculitis, hyperimmune reaction.
1. Novaya koronavirusnaya infekciya COVID-19/Akademiya poslediplomnogo obrazovaniya FGBU FMBA Rossii. - M., 2020
2. Revmaticheskie zabolevaniya v 3-h tomah/pod.red. Dzhona H. Klippela i dr., - M.: GEOTAR-Media, 2011 - 336 s.
3. Nasonov E.L., Baranov A.A., Shilkina N.P. Vaskulity i vaskulopatii. - Yaroslavl', Verhnyaya Volga. 1999. - 616 s.
4. Gennoinzhenernye biologicheskie preparaty v lechenii revmatoidnogo artrita/pod. red. E.L.Nasonova. - M.:IMA-press, 2013. - 549 s.
