The studies have shown that drinking alcohol by woman during pregnancy can lead not only to a full fetal alcohol syndrome, but also causes less severe dysmorphic, cognitive and behavioral disordersl, i.e. fetal alcohol spectrum disorders, leads to low birth weight, fetal death, and other complications of pregnancy. The purpose of this study was to investigate the influence of neuroprotective drugs tiocetam, cerebrocurin and piracetam on the marks of thin elements of energy metabolism and compensatory shunts in the brain of animals early age undergoing prenatal alcoholism. In pregnant rats with alcoholism were found neuroprotective and nootropic effects of cerebrocurin and tiocetam after parenterally administered to newborn animals for a period of 25 days. The above drugs have a beneficial effect on the main elements of the energy metabolism on the neonatal brain. On the severity of mitoprotective and energotropic mechanisms of neuroprotective action, aimed at reducing the negative impact of alcohol on the progeny, tiocetam and cerebrocurin far exceed basic nootropic drug piracetam.
prenatal alcoholism, energy metabolism, cerebrocurin, tiocetam, neuroprotection.
1. Abramchenko V.V. Klinicheskaya perinatologiya.SPb., 1996. 240 s.
2. Afanas´ev V.V. Tsitolavin v intensivnoy terapii. SPb, 2006. 36 s.
3. Afanas´ev V.V. Perinatal´naya nevrologiya. M.: Triada-Kh, 2001. 638 s.
4. Belєnіchev І.F., Levits´kiy Є.L., Gubs´kiy Yu.І. Antioksidantna sistema zakhistu organіzmu. Sovr. probl. toksikol. 2003. №2. S. 32-38.
5. Bunin A.T., Strizhakov A.N., Medvedev M.V. Oso-bennosti mozgovogo krovoobrashcheniya ploda v norme i pri sindrome zaderzhki ego razvitiya. Vopr. okhr. mat. 1990. № 2. S. 43-47.
6. Burduli G.M. Reproduktivnye poteri (prichiny, faktory riska, puti profilaktiki) : avtoref. dis. d-ra med. nauk. M., 1998. 47 s.
7. Kachalina T.S. Morfofunktsional´noe obosnovanie tselesoobraznosti ispol´zovaniya novykh antigipoksantov v kompleksnoy terapii fetoplatsentarnoy nedostatochnosti. Nizhegorodskiy med. zhurn. 2006. №7. S. 81-89.
8. Katkova N.Yu. Novyy podkhod k lecheniyu fetopla-tsentarnoy nedostatochnosti. Povolzh´e: Remedium, 2006. S. 28-33.
9. Kurtser M.A. Perinatal´naya smertnost´ i puti ee snizheniya : avtorefdis. d-ra med nauk. M., 2001. 36 s.
10. Mazur I.A., Chekman I.S., Belenichev I.F. Metabolitotropnye preparaty. Zaporozh´e, 2007. 309 s.
11. Kazimirova E.I., Dzhumagaziev A.A., Sibiryakova N.V., Minosyan N.V. Osobennosti nervno-psikhicheskogo razvitiya detey, rozhdennykh asotsial´nymi zhenshchinami. Trudy Astrakhanskoy gosudarstvennoy meditsinskoy akademii “Aktual´nye voprosy sovremennoy meditsiny”. 2005. T. 31 (LV). S. 36-39.
12. Sovremennye metody biokhimicheskikh issledova-niy (lipidnyy i energeticheskiy obmen) / Pod red. M.I. Prokhorovoy. L.: Izd-vo Leningradskogo un-ta, 1982. 272 s.
13. Tomilov I.K. Energeticheskoe obespechenie golov-nogo mozga ploda v usloviyakh platsentarnoy nedostatochno-sti. Vestn. Ivan-y med. akadem. 1998. T.3. №4. S.18-27.
14. Dzhumagaziev A.A., Kazimirova E.I., Sibiryakova N.V., Rybalkina V.A. Fizicheskoe razvitie detey, rozhdennykh ot narkozavisimykh zhenshchin. Trudy Astrakhanskoy gosudarstvennoy meditsinskoy akademii “Aktual´nye problemy pediatrii”. 2006. T. 34 (XLIX). S. 136-139.
15. Turley K., Vlahakes G. The fetal lamb models. The Ann. Of Surgery. 1998. P.422-446.
