employee
Russian Federation
employee
Russian Federation
GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
Purpose: Learning the state of the internal organs in newborns with severe perinatal asphyxia after general therapeutic hypothermia. Material and methods: 80 newborns with severe perinatal asphyxia born from January 2014 to May 2019 in Kursk were under observation. In the first 6 hours of life, 52 patients were started with general therapeutic hypothermia (1st observation group), 28 newborns did not perform hypothermia (2nd control group). All children underwent a dynamic complex radiological examination, included ultrasound of the brain, abdominal organs and retroperitoneal space, echocardiography with Doppler, chest X-rays. Results and discussion: In both groups of observations, radiation symptoms of liver and gallbladder changes were identified: a uniform increase in the echogenicity of the hepatic parenchyma (98.1 % of cases in group 1 and 100 % of cases in group 2, p > 0.05), visual “impoverishment” of the vascular pattern (98.1 % and 100 %, p > 0.05), hepatomegaly (19.2 % and 21.4 %, p > 0.05), thickening of the gallbladder walls, loose sediment or suspension in its lumen (7.7 % and 10.7 %, p > 0.05). All 80 examined patients showed a bilateral increase in echogenicity of the renal parenchyma with visual impoverishment of intraorgan blood flow and impaired corticomedullary differentiation. The described internal organs changes were reversible and due, in our opinion, mainly to the effect of asphyxiation and resuscitation measures. According to the results of chest X-ray, we did not reveal the effect of therapeutic hypothermia on the incidence of hospital pneumonia: it was found in 34.6 % newborns from the 1st group and in 42.9 % – from the 2nd one (p > 0.05). However, in the first 14 days of life the respiratory failure caused by edematous and hemorrhagic changes in patient’s lungs was detected more often in patients from observation group then in patients from control group: respectively 76.9 % and 42.8 % of cases (p <0.05). This indicates a negative effect of general therapeutic hypothermia on the respiratory system of newborns with severe perinatal asphyxia.
newborns, severe perinatal asphyxia, general therapeutic hypothermia, radiation examination
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