employee
Federal Research Centre for Project Evaluation and Consulting Services
employee
employee
Federal Research Centre for Project Evaluation and Consulting Services (Chef Researcher)
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employee
GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 31.08.08 Радиология
OKSO 32.08.12 Эпидемиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
Purpose: Experimental study of the antitumor mechanism of increasing the functional activity of phagocytes with a general effect on the body of a weak low-frequency vortex magnetic field (VMP). Material and methods: The functional activity of phagocytes was assessed upon activation by the intensity of chemiluminescence (CHL) on a Biolumat instrument (model LB 9500, by Berthold, Germany). Samples for in vitro and in vivo experiments were prepared according to generally accepted protocols. The impact of the VMP (Vmax = 3.0 mTl, f = 100 Hz) was performed using a Magnitoturbotron magnetotherapeutic installation (developed by NPF Az). Results: It was found in vitro experiments that the exposure of a suspension of VMP cells stimulated an increase in CHL by 58 % relative to the control, while the main contribution to the intensity of the signal of the CHL was made by neutrophils. In the study of the blood CHL of mice with subcutaneously inoculated melanoma B-16, it was established that the value of the specific CHL in the experiment with VFM by the end of the observation period (day 17) increased sharply (3 times) relative to the beginning of the observation and to the control at the same observation period was 3.3 times more. Experiments with whole blood of healthy donors and patients with breast cancer showed that the CHL curves over time were biphasic in nature and had two maxima, but the phase ratio was different. At donors, the main luminescence developed by the 100th minute, and a maximum of 30–40 min was mild. In patients with breast cancer, the first maximum at 30–40 min was the main, the second maximum was weak and came later than that of donors. Experiments with the effects of VMP on the organism of healthy and patients with breast cancer of people showed an increase in the functional activity of neutrophils as a result of exposure to VMP, but in patients with breast cancer, the level of CHL was significantly (3 times) higher than of healthy donors. Based on the research, it was concluded that exposure to the VMP is able to form a priming neutrophil. Сonclusion: It is shown that the overall effect of weak low-frequency VFM increases the level of nonspecific resistance of the organism to the tumor process, which expands the possibilities of rehabilitation of patients, allows expanding the compensatory capabilities of the body and reduce the risk of disease.
vortex magnetic field, magnetobiological effects, homeostasis, oxidation-reduction reactions, antitumor resistanse
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