employee
Krasnoyarsk V.F. Voino‐Yasenetsky State Medical University (Assistant of Department of Internal Medicine)
Krasnoyarsk, Krasnoyarsk, Russian Federation
employee
Krasnoyarsk V.F. Voino‐Yasenetsky State Medical University (Professor, Head of Department of Internal Medicine)
Krasnoyarsk, Krasnoyarsk, Russian Federation
Kraevaya klinicheskaya bol'nica, g. Krasnoyarsk
Krasnoyarsk, Krasnoyarsk, Russian Federation
Kraevaya klinicheskaya bol'nica, g. Krasnoyarsk
employee
Krasnoyarsk, Krasnoyarsk, Russian Federation
The purpose of the research was studying of clinical and diagnostic value of bronchial obstruction, hypoxemia, as well structural and functional condition of the left departments of heart in the patients with middle and severe degree of bronchial asthma. This research had prospective open design. Assessment of cardiac remodeling was carried out by means of the echocardiography with color Doppler mapping in period of exacerbation and after 12 months. Indicators of function of external respiration were estimated by means of the spirography and the bodyplethismography at the same periods. According to research data, it was revealed that with the severity of asthma is increasing the size of the left atrium and a decrease in the ratio of the AO/LA. The importance of early identification of a hypertrophy of a left ventricle in the patients with severe bronchial asthma is bound to the fre-quency of accompanying cardiac pathology and the correlation between hypertrophy of a left ventricle and the subsequent adverse clinical course of cardiovascular diseases. In patients with bronchial asthma parallel to the severity of the disease are formed changes of structural and functional state of myocardium of the left ventricle, causing diastolic dysfunction. The most significant risk factors in the formation of diastolic dysfunction of the left ventricle in patients with bronchial asthma are bronchial obstruction and hypoxemia.
bronchial asthma, left ventricle, diastolic dysfunction
Несмотря на активное изучение проблемы поражения сердца при бронхиальной астме (БА), в настоящее время нет единого мнения о характере изменений систоло-диастолических отношений, недостаточ-но изучены вопросы ремоделирования сердца, нечетко определены механизмы, обусловливающие структурно-геометрические изменения левого желудочка (ЛЖ) [5-7]. На сегодняшний день существует потребность в современных, доступных, скрининговых методах оценки сердечного ремоделирования и таким методом является эхокардиография с цветным доплеровским картированием. Однако до настоящего времени не полностью изучены механизмы, участвующие в структурно-функциональных изменениях ЛЖ у больных БА, в связи с чем сохраняет свою актуальность продолжение исследований взаимосвязи кардиоваскулярной и респираторной систем [2].
Цель исследования – оценить клинико-диагностическое значение бронхиальной обструкции, гипоксемии и структурно-функционального состояния левых отделов сердца у больных бронхиальной астмой среднетяжелого и тяжелого течения.
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