GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 32.08.12 Эпидемиология
OKSO 31.08.08 Радиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
Purpose: To estimate the feasibility of using linear-quadratic model (LQM) for planning neutron therapy regimens by the criterion of early radiation-induced reactions. Material and methods: The LQM, which described the reaction of tissues to fractionated irradiation, was used. The results obtained were compared with similar results found on the basis of the TDF model successfully used for neutron therapy planning. Results: The LQM parameters αn and βn for radiation induced skin damage were found. The dependence of a single dose of neutrons on the number of therapy sessions was obtained. This dependence was in good agreement with the analogous dependence found by the TDF model, which indicated the correctness of the method for calculating it. When using LQM for planning neutron therapy, the issue related with the time intervals between sessions was considered. For this purpose, the comparative calculations of the ratio of the total effect, determined by the LQM, and the TDF factor were carried out. The difference between the compared values did not exceed 6 %, thus allowing the time interval for planning neutron therapy using LQM to be excluded. Two methods to control the damage to normal tissue using LQM were considered. The first method was based on the evaluation of part of the used tolerance of the irradiated tissue, and the second one was carried out by transferring the applied dose fractionation regimen of neutron therapy to the isoeffective standard regimen of photon therapy. Conclusion: It was shown that LQM can be used for planning neutron therapy regimens in cancer patients by the criterion of early radiation-induced reactions. The results obtained extend the potential of radiobiological planning of neutron therapy and can serve as a basis for the development of the method of using LQM in prediction of late radiation-induced complications.
neutron therapy, planning, linear-quadratic model, early radiation-induced reactions
1. Wagner FM, Specht H, Loeper-Kabasakal B, Breitkreutz H. Fast neutron therapy: a status report. Siberian Journal of Oncology. 2015;(6):5-11. Russian.
2. Lisin VA. TDF model for fast neutron radiation therapy of malignant tumors. Medical Radiology. 1988;33(9):9-12. Russian.
3. Pavlov AS, Fadeeva MA, Karyakina NF, Kostromina KN, Simakina EP, et al. Linear-quadratic model in the calculation of isoeffective doses and in the evaluation of anti-cancer effect and radiation-induced injuries. Manual for physicians. Moscow; 2005. 67 p. Russian.
4. Klepper LYa. Comparative analysis of the LQ model and the Ellis model in skin irradiation. Medical Physics. 2010;(4):29-36. Russian.
5. Akimov AA, Afanasyev BP, Kozlov AP, Nikolaeva EN, Ilyin NV, Mamin TE. Evaluation of the biological effectiveness of different dose fractionation regimes in external beam radiation therapy. – Sankt Peterbourg: SPbMAPO press; 2008. 26 p. Russian.
6. Joiner MC, Bentzen SM. Fractionation: the linear-quadratic approach. In: Basic Clinical Radiobiology. Ed. by Joiner MC, A van der Kogel; 2009. P. 102-20.
7. Velikaya VV, Musabaeva LI, Startseva ZhA, Lisin VA. 6.3 fast neutrons in the treatment of locally recurrent breast cancer. Voprosy Onkologii. 2015;61(4):583-5. Russian.
8. Musabaeva LI, Startseva ZhA, Gribova OV, Velikaya VV, Lisin VA. Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron. AIP Conference Proceedings. 2016. Vol. 1760: Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016: Proceedings of the International conference; 2016 Mar 22-25; Tomsk, Russia; 2016. p. 020050, 5. Available from: http://earchive.tpu.ru/handle/11683/35786. DOI: 10.1063/1.4960269.
9. Gribova OV, Musabaeva LI, Choynzonov EL, Lisin VA, Novikov VA. Neutron Therapy for Salivary and Thyroid Gland Cancer. AIP Conference Proceedings. 2016. Vol. 1760; 2016. p. 020021, 5. Available from: http://earchive.tpu.ru/handle/11683/35774.
10. Velikaya VV, Musabaeva LI, Lisin VA, Startseva ZA, Startseva ZhA. 6.3 MeV fast neutrons in the treatment of patients with locally advanced and locally recurrent breast cancer. AIP Conference Proceedings. 2016. Vol. 1760; 2016. p. 020069, 4. Available from: http://earchive.tpu.ru/handle/11683/35796.
11. Gulidov IA, Mardynsky YuS, Tsyb AF, Sysoev AS. Neutrons of nuclear reactors in the treatment of malignant neoplasms. Obninsk; 2001. 132 p. Russian.
12. Vazhenin AV, Rykovanov GN. Ural Center for Neutron Therapy: history, methodology, work results. Moscow: Publishing house of RAMS; 2008. 124 p. Russian.
13. Kondratjeva AG, Kolchuzhkin AM, Lisin VA, Tropin IS. Properties of absorbed dose distribution in heterogeneous media. Journal of Physics: Conference Series. 2006;41(1)B:527-50.
14. Lisin VA. Estimation of the parameters of the linear-quadratic model in neutron therapy // Medical Physics. 2010;(4):5-12. Russian.
15. Catterall M, Bewley DK. Fast neutrons in the Treatment of Cancer. London, Academic Press, New York, Grune and Stratto; 1979. 394 p.
16. Dale RG, Jones B. The assessment of RBE effects using the concept of biologically effective dose. Int J Radiation Oncol Biol Phys. 1999;43(3):639-45.
17. Kholin VV. Radiobiological bases of radiation therapy of malignant tumors. – Leningrad. Medicin»; 1979. 200 p. Russian.
18. Musabaeva LI, Slonimskaya EM, Lisin VA, Shagiakhmetova RA, Yalova MF. Neutron therapy in the treatment of locally advanced breast cancer. Medical Radiology and Radiation Safety.1998;43(2):9-54. Russian.