The paper presents the data on the influence of remote consequences separate, combined and cumulative impact of agrochemicals (fertilizers and pesticides) on female mortality (1997-2006) from malignant tumors of the genitalia in the rural areas of the Republic of Dagestan. The intensive use of agrochemicals before 1995 exceeded the critical load level according to data of V.I. Polchenko and co-authors (3.93 kg/ha) and the classification of World Health Organization (4,0-5,0 kg/ha) in ten times and more. As objective quantitative indicators of the intensive use of pesticides and mineral fertilizers were applied territorial load and range of index territorial load of pesticides. To assess the environmental significance separate, combined and cumulative impacts of priority anthropogenic co-factors the author carried out predominantly two-factor analysis of variance. The share of influence, correlation coefficient and the Fisher test for each factor separately, but also for its combined and cumulative actions were calculated. It is shown the existence of significant correlation mortality from genital cancer with total territorial load of mineral fertilizers. The more significant the influence of factors on mortality was identified in terms of the total impact of the assortment index territorial load of organo-phosphorus compounds and copper-containing pesticides. It allows to considering them as secondary factors of cancer risk of death for women in rural areas.
malignant tumors, cancer of the female genitalia, chemicals, means of chemicals
По данным литературы, к числу значимых антропогенных экологических факторов риска злокачественных новообразований (ЗН), в том числе и женских гениталий, относятся средства химизации (минеральные удобрения и пестициды), применяемые в сельском хозяйстве [1]. Характер и интенсивность их влияния зависят как от номенклатуры факторов, воздействующих синэкологически (сочетанно и суммарно), так и условий, в которых реализуется их биологическое действие непосредственно и, особенно, в отдаленные сроки [2]. В равной степени это справедливо и для Республики Дагестан (РД) – региона со сложными природными элементами экосистемы. Республика имеет ярко выраженные климатогеографические особенности – высотно-климатические пояса (зоны) (равнинная, предгорная и горная) от 16 до
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