ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
Rubrics: EXPERIMENTAL RESEARCH
Authors:
1.
East-Siberian Institution of Medical and Ecological Research
(Laboratory of Biological Modeling and Translational Medicine, Leading Research Officer)
Angarsk, Irkutsk region, Russian Federation
Angarsk, Irkutsk region, Russian Federation
2.
East-Siberian Institution of Medical and Ecological Research
(Laboratory of Biological Modeling and Translational Medicine, Research Officer)
Angarsk, Irkutsk region, Russian Federation
Angarsk, Irkutsk region, Russian Federation
3.
Irkutsk National Research Technical University
(Department of Innovative Technologies of Physical-Technical Institute, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Irkutsk, Irkutsk region, Russian Federation
5.
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 97
to 100
Status:
Published
Received:
02.11.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
dioksid kremniya, nanostruktury, laboratornye zhivotnye, toksichnost'
Abstract (English):
Koncentrat nanostruktur na osnove dioksida kremniya, poluchaemyy iz othodov proizvodstva metallicheskogo kremniya, yavlyaetsya perspektivnoy dobavkoy dlya povysheniya prochnosti stroitel'nyh materialov. Kremnievaya pyl' predstavlyaet soboy konglomeraty tverdyh chastic, imeyuschie razmery ot submikronnyh do neskol'kih desyatkov mikron so slozhnym himicheskim i fazovym sostavom, pri etom naibol'shuyu massovuyu dolyu sostavlyaet dioksid kremniya (ne menee 98 %). Koncentrat soderzhit kak otdel'nye nanochasticy razmerom 1 mkm, tak i aglomeraty ot 1 do 45 mkm. Reshayuschim v voprose o celesoobraznosti ispol'zovaniya dannogo nanoprodukta yavlyaetsya biobezopasnost' lyudey, kontaktiruyuschih s nim. Opredelenie parametrov ostroy toksichnosti, vidovoy i polovoy chuvstvitel'nosti provodili na autbrednyh belyh myshah i krysah oboego pola. Issleduemuyu substanciyu suspendirovali v distillirovannoy vode i vvodili zhivotnym natoschak vnutrizheludochno s pomosch'yu atravmatichnogo metallicheskogo zonda, doziruya putem izmeneniya vvodimogo ob'ema, ne prevyshavshego 1 ml dlya belyh myshey i 2 ml dlya krys. Provedeno ispytanie predel'noy dozy v 2000 mg/kg massy tela v dva etapa, po 3 osobi na kazhdom etape. Mestnoe razdrazhayuschee deystvie koncentrata nanostruktur na osnove dioksida kremniya na kozhu pri odnokratnom vozdeystvii izuchali na 8 belyh krysah samcah i samkah, massoy 180–200 g. Ustanovleno, chto po parametru DL50 ispytuemaya substanciya pri ostrom vnutrizheludochnom puti postupleniya harakterizuetsya kak veschestvo, imeyuschee nizkuyu opasnost' ostroy toksichnosti, i otnositsya k V klassu opasnosti (DL50 > 2000 mg/kg). Velichiny srednesmertel'nyh doz (DL50) nezavisimo ot vida i pola zhivotnyh opredelyalis' kak >2000 mg/kg, chto svidetel'stvovalo ob otsutstvii razlichiy v vidovoy i polovoy chuvstvitel'nosti zhivotnyh. Pri odnokratnom nanesenii na kozhnye pokrovy otmecheno slabo vyrazhennoe razdrazhayuschee deystvie, ischezayuschee cherez 16 chasov posle okonchaniya vozdeystviya.
Koncentrat nanostruktur na osnove dioksida kremniya, poluchaemyy iz othodov proizvodstva metallicheskogo kremniya, yavlyaetsya perspektivnoy dobavkoy dlya povysheniya prochnosti stroitel'nyh materialov. Kremnievaya pyl' predstavlyaet soboy konglomeraty tverdyh chastic, imeyuschie razmery ot submikronnyh do neskol'kih desyatkov mikron so slozhnym himicheskim i fazovym sostavom, pri etom naibol'shuyu massovuyu dolyu sostavlyaet dioksid kremniya (ne menee 98 %). Koncentrat soderzhit kak otdel'nye nanochasticy razmerom 1 mkm, tak i aglomeraty ot 1 do 45 mkm. Reshayuschim v voprose o celesoobraznosti ispol'zovaniya dannogo nanoprodukta yavlyaetsya biobezopasnost' lyudey, kontaktiruyuschih s nim. Opredelenie parametrov ostroy toksichnosti, vidovoy i polovoy chuvstvitel'nosti provodili na autbrednyh belyh myshah i krysah oboego pola. Issleduemuyu substanciyu suspendirovali v distillirovannoy vode i vvodili zhivotnym natoschak vnutrizheludochno s pomosch'yu atravmatichnogo metallicheskogo zonda, doziruya putem izmeneniya vvodimogo ob'ema, ne prevyshavshego 1 ml dlya belyh myshey i 2 ml dlya krys. Provedeno ispytanie predel'noy dozy v 2000 mg/kg massy tela v dva etapa, po 3 osobi na kazhdom etape. Mestnoe razdrazhayuschee deystvie koncentrata nanostruktur na osnove dioksida kremniya na kozhu pri odnokratnom vozdeystvii izuchali na 8 belyh krysah samcah i samkah, massoy 180–200 g. Ustanovleno, chto po parametru DL50 ispytuemaya substanciya pri ostrom vnutrizheludochnom puti postupleniya harakterizuetsya kak veschestvo, imeyuschee nizkuyu opasnost' ostroy toksichnosti, i otnositsya k V klassu opasnosti (DL50 > 2000 mg/kg). Velichiny srednesmertel'nyh doz (DL50) nezavisimo ot vida i pola zhivotnyh opredelyalis' kak >2000 mg/kg, chto svidetel'stvovalo ob otsutstvii razlichiy v vidovoy i polovoy chuvstvitel'nosti zhivotnyh. Pri odnokratnom nanesenii na kozhnye pokrovy otmecheno slabo vyrazhennoe razdrazhayuschee deystvie, ischezayuschee cherez 16 chasov posle okonchaniya vozdeystviya.
Keywords:
dioksid kremniya, nanostruktury, laboratornye zhivotnye, toksichnost'
dioksid kremniya, nanostruktury, laboratornye zhivotnye, toksichnost'
1. Spislit dioksid kremniya
