DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
Rubrics: PEDIATRICS
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Pediatrics and Neurophysiology, Leading Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka
(laboratoriya fiziologii i patologii endokrinnoy sistemy, zaveduyuschiy)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(direktor)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Center for Human Reproduction and Family Health Problems
(Laboratory of Pathophysiology, Leading Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 53
to 57
Status:
Published
Received:
31.10.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
podrostki, essencial'naya arterial'naya gipertenziya, gormony, sindrom obstruktivnogo apnoe sna
Abstract (English):
Sindrom obstruktivnogo apnoe sna (SOAS) tesno svyazan s arterial'noy gipertenziey (AG) i rassmatrivaetsya kak endogennyy stressor. Osnovnym komponentom v realizacii otvetnoy reakcii pri vozdeystvii lyubogo stressora yavlyaetsya aktivaciya neyroendokrinnoy sistemy, odnako otvet na gipoksiyu pri SOAS mozhet byt' raznoobraznym. My izuchili osobennosti gormonal'nogo statusa u podrostkov s essencial'noy AG (EAG) pri SOAS. Obsledovano 38 mal'chikov 14–17 let s EAG (18 pacientov s SOAS i 20 – bez SOAS). SOAS byl verificirovan pri pomoschi polisomnografii s ispol'zovaniem sistemy GRASS-TEFEFACTOR Twin PSG (USA). EAG diagnostirovali pri provedenii sutochnogo monitoringa arterial'nogo davleniya na apparate Oscar 2 OXFORD Medilog Prima (UK). Gormonal'nyy status opredelyali s pomosch'yu avtomaticheskogo analizatora «Cobos ELL» (SShA). Vse razlichiya schitalis' statisticheski znachimymi pri p < 0,05. Statisticheski znachimoe povyshenie urovnya kortizola bylo otmecheno u podrostkov s SOAS (745,8 ± 6,4 protiv 493,2 ± 3,2 nmol'/l u pacientov bez SOAS). Urovni prolaktina i tireotropina u pacientov obeih grupp ne imeli statisticheski znachimyh razlichiy, no nablyudalas' otchetlivaya tendenciya k ih uvelicheniyu u podrostkov s SOAS (482,8 ± 4,2 i 442,2 ± 4,1 mME/l, 1,95 ± 0,9 i 1,5 ± 0,2 mkME/ml v gruppe A i v gruppe V sootvetstvenno; r < 0,05). Rezul'taty dannogo issledovaniya svidetel'stvuyut o hronicheskom stresse pri nalichii SOAS u podrostkov s EAG. Eto svyazano s vliyaniem izbytochnoy fragmentacii sna i intermittiruyuschey gipoksii na sostoyanie sistemy neyroendokrinnoy regulyacii s vysvobozhdeniem kompensatornyh stressovyh gormonov.
Sindrom obstruktivnogo apnoe sna (SOAS) tesno svyazan s arterial'noy gipertenziey (AG) i rassmatrivaetsya kak endogennyy stressor. Osnovnym komponentom v realizacii otvetnoy reakcii pri vozdeystvii lyubogo stressora yavlyaetsya aktivaciya neyroendokrinnoy sistemy, odnako otvet na gipoksiyu pri SOAS mozhet byt' raznoobraznym. My izuchili osobennosti gormonal'nogo statusa u podrostkov s essencial'noy AG (EAG) pri SOAS. Obsledovano 38 mal'chikov 14–17 let s EAG (18 pacientov s SOAS i 20 – bez SOAS). SOAS byl verificirovan pri pomoschi polisomnografii s ispol'zovaniem sistemy GRASS-TEFEFACTOR Twin PSG (USA). EAG diagnostirovali pri provedenii sutochnogo monitoringa arterial'nogo davleniya na apparate Oscar 2 OXFORD Medilog Prima (UK). Gormonal'nyy status opredelyali s pomosch'yu avtomaticheskogo analizatora «Cobos ELL» (SShA). Vse razlichiya schitalis' statisticheski znachimymi pri p < 0,05. Statisticheski znachimoe povyshenie urovnya kortizola bylo otmecheno u podrostkov s SOAS (745,8 ± 6,4 protiv 493,2 ± 3,2 nmol'/l u pacientov bez SOAS). Urovni prolaktina i tireotropina u pacientov obeih grupp ne imeli statisticheski znachimyh razlichiy, no nablyudalas' otchetlivaya tendenciya k ih uvelicheniyu u podrostkov s SOAS (482,8 ± 4,2 i 442,2 ± 4,1 mME/l, 1,95 ± 0,9 i 1,5 ± 0,2 mkME/ml v gruppe A i v gruppe V sootvetstvenno; r < 0,05). Rezul'taty dannogo issledovaniya svidetel'stvuyut o hronicheskom stresse pri nalichii SOAS u podrostkov s EAG. Eto svyazano s vliyaniem izbytochnoy fragmentacii sna i intermittiruyuschey gipoksii na sostoyanie sistemy neyroendokrinnoy regulyacii s vysvobozhdeniem kompensatornyh stressovyh gormonov.
Keywords:
podrostki, essencial'naya arterial'naya gipertenziya, gormony, sindrom obstruktivnogo apnoe sna
podrostki, essencial'naya arterial'naya gipertenziya, gormony, sindrom obstruktivnogo apnoe sna
1. Spislit gormon status u mal'chikov
