INTERRELATION OF CHANGES IN CONCENTRATION OF LEPTIN AND Ω-3 FAMILY ACIDS IN THE PLACENTA AT THE REACTIVATION OF CYTOMEGALOVIRUS INFECTION IN THE III TRIMESTER OF HUMAN PREGNANCY
Rubrics: BIOLOGICAL CHEMISTRY
Authors:
1.
FGBNU "Dal'nevostochnyy nauchnyy centr fiziologii i patologii dyhaniya"
(veduschiy nauchnyy sotrudnik)
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
2.
Far Eastern Scientific Center of Physiology and Pathology of Respiration
(rukovoditel' laboratorii)
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
3.
Far Eastern Scientific Center of Physiology and Pathology of Respiration
(glavnyy nauchnyy sotrudnik)
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
4.
FGBNU «Dal'nevostochnyy nauchnyy centr fiziologii i patologii dyhaniya»
(starshiy nauchnyy sotrudnik)
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Type:
Article
Pages:
from 23
to 26
Status:
Published
Received:
23.10.2017
Accepted:
02.11.2017
Published:
02.11.2017
Subject area:
UDK 57 Биологические науки
Language:
Russian
Keywords:
leptin, eykozapentaenovaya kislota, dokozageksaenovaya kislota, placenta, citomegalovirusnaya infekciya
Abstract (English):
V rabote izuchena vzaimosvyaz' izmeneniy koncentracii leptina i ω-3 polinenasyschennyh eykozopentaenovoy i dokozogeksaenovoy zhirnyh kislot v gomogenate placenty rozhenic. Osnovnuyu gruppu sostavili 42 placenty, vzyatye v rodah u zhenschin, perenesshih reaktivaciyu hronicheskoy citomegalovirusnoy infekcii s titrom antitel Ig klassa G k citomegalovirusu 1:1600 v III trimestre gestacii. Kontrol'nuyu gruppu sostavili 35 placent, vzyatye v rodah ot prakticheski zdorovyh rozhenic. Soderzhanie ω-3 polinenasyschennyh zhirnyh kislot v gomogenate placentarnoy tkani zhenschin issledovali metodom gazozhidkostnoy hromatografii. Koncentraciyu leptina izuchali metodom immunofermentnogo analiza. V hode issledovaniya ustanovleno, chto reaktivaciya hronicheskoy citomegalovirusnoy infekcii v III trimestre beremennosti associiruetsya so snizheniem soderzhaniya polinenasyschennyh ω-3 eykozapentaenovoy kisloty na 23 % (p < 0,01) i dokozageksaenovoy kisloty na 42 % (p < 0,001) v gomogenate placenty rozhenic pri odnovremennom uvelichenii koncentracii leptina na 61 % (p < 0,001). Pri analize vzaimosvyazi sootnosheniya koncentracii eykozapentaenovoy i dokozogeksaenovoy ω-3 kislot v gomogenate placenty rozhenic s citomegalovirusnoy infekciey s sootnosheniem koncentracii leptina otmechalas' obratnaya svyaz' mezhdu dannymi pokazatelyami: koefficient korrelyacii r sostavil, sootvetstvenno, –0,72 (p < 0,01) i –0,80 (p < 0,001). Vyyavlennye izmeneniya v gomogenate placenty rozhenic pokazyvayut, chto v usloviyah citomegalovirusnoy infekcii narushayutsya mehanizmy regulirovaniya peredachi polinenasyschennyh zhirnyh kislot ω-3 semeystva iz perifericheskoy krovi materi v krov' razvivayuschegosya ploda cherez placentu. Soderzhanie leptina pri beremennosti yavlyaetsya vazhnym pokazatelem, nesuschim informaciyu ne tol'ko ob energeticheskih zapasah materinskogo organizma, no i o sostoyanii fetoplacentarnogo kompleksa
V rabote izuchena vzaimosvyaz' izmeneniy koncentracii leptina i ω-3 polinenasyschennyh eykozopentaenovoy i dokozogeksaenovoy zhirnyh kislot v gomogenate placenty rozhenic. Osnovnuyu gruppu sostavili 42 placenty, vzyatye v rodah u zhenschin, perenesshih reaktivaciyu hronicheskoy citomegalovirusnoy infekcii s titrom antitel Ig klassa G k citomegalovirusu 1:1600 v III trimestre gestacii. Kontrol'nuyu gruppu sostavili 35 placent, vzyatye v rodah ot prakticheski zdorovyh rozhenic. Soderzhanie ω-3 polinenasyschennyh zhirnyh kislot v gomogenate placentarnoy tkani zhenschin issledovali metodom gazozhidkostnoy hromatografii. Koncentraciyu leptina izuchali metodom immunofermentnogo analiza. V hode issledovaniya ustanovleno, chto reaktivaciya hronicheskoy citomegalovirusnoy infekcii v III trimestre beremennosti associiruetsya so snizheniem soderzhaniya polinenasyschennyh ω-3 eykozapentaenovoy kisloty na 23 % (p < 0,01) i dokozageksaenovoy kisloty na 42 % (p < 0,001) v gomogenate placenty rozhenic pri odnovremennom uvelichenii koncentracii leptina na 61 % (p < 0,001). Pri analize vzaimosvyazi sootnosheniya koncentracii eykozapentaenovoy i dokozogeksaenovoy ω-3 kislot v gomogenate placenty rozhenic s citomegalovirusnoy infekciey s sootnosheniem koncentracii leptina otmechalas' obratnaya svyaz' mezhdu dannymi pokazatelyami: koefficient korrelyacii r sostavil, sootvetstvenno, –0,72 (p < 0,01) i –0,80 (p < 0,001). Vyyavlennye izmeneniya v gomogenate placenty rozhenic pokazyvayut, chto v usloviyah citomegalovirusnoy infekcii narushayutsya mehanizmy regulirovaniya peredachi polinenasyschennyh zhirnyh kislot ω-3 semeystva iz perifericheskoy krovi materi v krov' razvivayuschegosya ploda cherez placentu. Soderzhanie leptina pri beremennosti yavlyaetsya vazhnym pokazatelem, nesuschim informaciyu ne tol'ko ob energeticheskih zapasah materinskogo organizma, no i o sostoyanii fetoplacentarnogo kompleksa
Keywords:
leptin, eykozapentaenovaya kislota, dokozageksaenovaya kislota, placenta, citomegalovirusnaya infekciya
leptin, eykozapentaenovaya kislota, dokozageksaenovaya kislota, placenta, citomegalovirusnaya infekciya
1. 1 Ishutina spislit
