PHYLOGEORGAPHY OF MYCOBACTERIUM TUBERCULOSIS IN CENTRAL AND BORDER MONGOLIA
Rubrics: EPIDEMIOLOGY
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Department of Epidemiology and Microbiology, Research Assistant)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Buryat State University
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
3.
Ulaanbaatar, Mongolia
4.
Ulaanbaatar, Mongolia
5.
Ulaanbaatar, Mongolia
6.
Ulaanbaatar, Mongolia
7.
Ulaanbaatar, Mongolia
8.
Ulaanbaatar, Mongolia
9.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Epidemiologically and Socially Significant Infections, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 180
to 185
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
Mycobacterium tuberculosis, MIRU-VNTR, genotip Beijing, filogeografiya, geneticheskoe raznoobrazie, tuberkulez v Mongolii
Abstract (English):
Vsemirnoe rasprostranenie Mycobacterium tuberculosis i masshtaby zabolevaemosti tuber-kulezom obuslovlivayut vazhnost' epidemiologicheskih issledovaniy vozbuditelya: bakte-riologicheskih, fiziologicheskih, geneticheskih i, krome togo, osobennostey prostranstven-noy struktury grupp mikroorganizmov, otlichayuschihsya po patogeneticheskomu potencialu i filogeneticheskim distanciyam. Dannaya rabota posvyaschena izucheniyu filogeografii epide-micheski znachimyh geneticheskih grupp M. tuberculosis, cirkuliruyuschih v Mongolii – regi-one s vysokoy zabolevaemost'yu tuberkulezom. Po rezul'tatam issledovaniya 309 shtammov vozbuditelya metodami MIRU-VNTR tipirovaniya, LSP-tipirovaniya i subtipirovaniya (sravnenie rezul'tatov s referensnymi MIRU-VNTR profilyami, vyyavlenie specifichnyh SNPs) v kachestve dominiruyuschego identificirovan genotip Beijing (subtip CC4). Dlya dan-nogo genotipa harakterna vysokaya chastota klasterizacii, chto svidetel'stvuet kak o ego epidemicheskoy opasnosti, tak i ob otnositel'no nedavnem zanose «uspeshnyh» shtammov na territoriyu Mongolii. Vyyavlena takzhe dostatochno odnorodnaya struktura raspredeleniya genotipov i subtipov vozbuditelya v predelah izuchaemogo regiona, kotoraya otlichaetsya ot struktury rossiyskoy populyacii M. tuberculosis svoim subtipicheskim sostavom. Takim obrazom, v kachestve vozmozhnogo istochnika rasprostraneniya shtammov subtipa CC4 genotipa Beijing na territoriyu Mongolii predpolagayutsya sosednie Vostochno-Aziatskie regiony, naibolee veroyatno – severnye provincii Kitaya (Vnutrennyaya Mongoliya) ili blizhayshie strany Yugo-Vostochnoy Azii.
Vsemirnoe rasprostranenie Mycobacterium tuberculosis i masshtaby zabolevaemosti tuber-kulezom obuslovlivayut vazhnost' epidemiologicheskih issledovaniy vozbuditelya: bakte-riologicheskih, fiziologicheskih, geneticheskih i, krome togo, osobennostey prostranstven-noy struktury grupp mikroorganizmov, otlichayuschihsya po patogeneticheskomu potencialu i filogeneticheskim distanciyam. Dannaya rabota posvyaschena izucheniyu filogeografii epide-micheski znachimyh geneticheskih grupp M. tuberculosis, cirkuliruyuschih v Mongolii – regi-one s vysokoy zabolevaemost'yu tuberkulezom. Po rezul'tatam issledovaniya 309 shtammov vozbuditelya metodami MIRU-VNTR tipirovaniya, LSP-tipirovaniya i subtipirovaniya (sravnenie rezul'tatov s referensnymi MIRU-VNTR profilyami, vyyavlenie specifichnyh SNPs) v kachestve dominiruyuschego identificirovan genotip Beijing (subtip CC4). Dlya dan-nogo genotipa harakterna vysokaya chastota klasterizacii, chto svidetel'stvuet kak o ego epidemicheskoy opasnosti, tak i ob otnositel'no nedavnem zanose «uspeshnyh» shtammov na territoriyu Mongolii. Vyyavlena takzhe dostatochno odnorodnaya struktura raspredeleniya genotipov i subtipov vozbuditelya v predelah izuchaemogo regiona, kotoraya otlichaetsya ot struktury rossiyskoy populyacii M. tuberculosis svoim subtipicheskim sostavom. Takim obrazom, v kachestve vozmozhnogo istochnika rasprostraneniya shtammov subtipa CC4 genotipa Beijing na territoriyu Mongolii predpolagayutsya sosednie Vostochno-Aziatskie regiony, naibolee veroyatno – severnye provincii Kitaya (Vnutrennyaya Mongoliya) ili blizhayshie strany Yugo-Vostochnoy Azii.
Keywords:
Mycobacterium tuberculosis, MIRU-VNTR, genotip Beijing, filogeografiya, geneticheskoe raznoobrazie, tuberkulez v Mongolii
Mycobacterium tuberculosis, MIRU-VNTR, genotip Beijing, filogeografiya, geneticheskoe raznoobrazie, tuberkulez v Mongolii
1. Spislit filogeografiya
