METABOLISM AND OBESITY: ROLE OF LEPTIN RECEPTOR GENE
Rubrics: GENETICS, PROTEOMICS & METABOLOMICS
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(laboratoriya personalizirovannoy mediciny, vrach klinicheskoy laboratornoy diagnostiki)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(laboratoriya personalizirovannoy mediciny, rukovoditel')
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(direktor)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Irkutsk, Irkutsk region, Russian Federation
5.
Scientific Centre for Family Health and Human Reproduction Problems
(Department of Adolescent Gynecology, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
6.
Scientific Centre for Family Health and Human Reproduction Problems
(nauchnyy rukovoditel')
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 56
to 62
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
ozhirenie, izbytochnaya massa tela, podrostki, LEPR Q223R
Abstract (English):
Obosnovanie Izvestno bolee 119 lokusov genov cheloveka, otvetstvennyh za razvitie ozhireniya u vzroslyh. Odnim iz takih yavlyaetsya polimorfizm Q223R gena receptora leptina (LEPR), dlya kotorogo ustanovlena associaciya s izbytochnoy massoy tela i ozhireniem u vzroslyh, odnako ostaetsya spornym vopros o ego roli v razvitii ozhireniya u podrostkov. Cel': opredelit' associaciyu polimorfizma Q223R gena LEPR c nekotorymi biohimicheskimi i gormonal'nymi pokazatelyami krovi u devochek-podrostkov s normal'nym vesom i s izbytochnoy massoy tela i ozhireniem. Materialy i metody: 103 devochki podrostkovogo vozrasta (14-17 let) razdeleny na 2 gruppy: 43 - s normal'nym vesom (SDS IMT 0,311±0,585), 65 - s izbytochnoy massoy tela i ozhireniem (SDS IMT 2,255±0,739). Vsem devochkam provedeny antropometricheskie (rost, ves, IMT, SDS IMT), laboratornye (trigliceridy, obschiy holesterin i ego frakciy, TTG, T4svobodnyy, leptin) i molekulyarno-geneticheskoe (na nositel'stvo variantov polimorfizma Q223R gena LEPR) issledovaniya. Statisticheskiy analiz rezul'tatov provodilsya na programmnom obespechenii «STATISTICA 8.0» s ispol'zovaniem neparametricheskogo metoda Manna-Uitni. Rezul'taty: V kontrol'noy gruppe vyyavlena associaciya nositel'stva RR-genotipa s SDS IMT (r=0,006), so snizheniem urovnya svobodnogo tiroksina (r=0,0124) i uvelicheniem TTG (r=0,006). Associacii issledovannyh parametrov s izuchaemym polimorfizmom v gruppe s izbytochnoy massoy tela i ozhireniem ne vyyavleno. Zaklyuchenie: Pokazana associaciya R-allelya s uvelicheniem SDS IMT, TTG, a takzhe so snizheniem urovnya T4svobodnyy v gruppe kontrolya.
Obosnovanie Izvestno bolee 119 lokusov genov cheloveka, otvetstvennyh za razvitie ozhireniya u vzroslyh. Odnim iz takih yavlyaetsya polimorfizm Q223R gena receptora leptina (LEPR), dlya kotorogo ustanovlena associaciya s izbytochnoy massoy tela i ozhireniem u vzroslyh, odnako ostaetsya spornym vopros o ego roli v razvitii ozhireniya u podrostkov. Cel': opredelit' associaciyu polimorfizma Q223R gena LEPR c nekotorymi biohimicheskimi i gormonal'nymi pokazatelyami krovi u devochek-podrostkov s normal'nym vesom i s izbytochnoy massoy tela i ozhireniem. Materialy i metody: 103 devochki podrostkovogo vozrasta (14-17 let) razdeleny na 2 gruppy: 43 - s normal'nym vesom (SDS IMT 0,311±0,585), 65 - s izbytochnoy massoy tela i ozhireniem (SDS IMT 2,255±0,739). Vsem devochkam provedeny antropometricheskie (rost, ves, IMT, SDS IMT), laboratornye (trigliceridy, obschiy holesterin i ego frakciy, TTG, T4svobodnyy, leptin) i molekulyarno-geneticheskoe (na nositel'stvo variantov polimorfizma Q223R gena LEPR) issledovaniya. Statisticheskiy analiz rezul'tatov provodilsya na programmnom obespechenii «STATISTICA 8.0» s ispol'zovaniem neparametricheskogo metoda Manna-Uitni. Rezul'taty: V kontrol'noy gruppe vyyavlena associaciya nositel'stva RR-genotipa s SDS IMT (r=0,006), so snizheniem urovnya svobodnogo tiroksina (r=0,0124) i uvelicheniem TTG (r=0,006). Associacii issledovannyh parametrov s izuchaemym polimorfizmom v gruppe s izbytochnoy massoy tela i ozhireniem ne vyyavleno. Zaklyuchenie: Pokazana associaciya R-allelya s uvelicheniem SDS IMT, TTG, a takzhe so snizheniem urovnya T4svobodnyy v gruppe kontrolya.
Keywords:
ozhirenie, izbytochnaya massa tela, podrostki, LEPR Q223R
ozhirenie, izbytochnaya massa tela, podrostki, LEPR Q223R
1. Spislit metabolizm i ozhirenie
