HANTAVIRUS INFECTION AMONG PATIENTS WITH FEVER OF UNCLEAR ETIOLOGY AND SMALL MAMMALS IN PRIBAIKALYE
Rubrics: EPIDEMIOLOGY
Authors:
1.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
2.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Leading Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
3.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Senior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
4.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Clinical Research Assistant)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
5.
Scientific Centre for Family Health and Human Reproduction Problems
(Junior Research Officer)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
6.
State Research Center of Virology and Biotechnology “Vector”
(Head of the Laboratory)
Novosibirsk, Novosibirsk, Russian Federation
Novosibirsk, Novosibirsk, Russian Federation
7.
University of Hawaii at Manoa
(Professor)
Manoa, United States of America
Manoa, United States of America
8.
Scientific Centre for Family Health and Human Reproduction Problems
(Laboratory of Arthropod-Borne Infections, Head)
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Type:
Article
Pages:
from 174
to 179
Status:
Published
Received:
19.10.2017
Accepted:
22.11.2017
Published:
22.11.2017
Subject area:
UDK 61 Медицина. Охрана здоровья
Language:
Russian
Keywords:
gemorragicheskaya lihoradka s pochechnym sindromom, hantavirusy, antigen hantavirusov, antitela k hantavirusam
Abstract (English):
Vvedenie. Po oficial'noy statistike sredi prirodno-ochagovyh bolezney v Rossiyskoy Federacii zabolevaniya, vyzyvaemye hantavirusami, zanimayut odno iz pervyh mest. Material i metody. V rabote predstavleny rezul'taty issledovaniya 92 syvorotok krovi bol'nyh lyudey, obrativshihsya v Centr diagnostiki i profilaktiki kleschevyh infekciy FGBNU «Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka» s zhalobami na uhudshenie sostoyaniya zdorov'ya. V zavisimosti ot srokov prisasyvaniya klescha ili predpolagaemogo ukusa klescha vsem pacientam byli provedeny serologicheskie i/ili PCR-issledovaniya na nalichie antigena/antitel IgM, IgG k virusu kleschevogo encefalita (KE), antitel IgM, IgG k kleschevomu borreliozu (KB), antitel IgM, IgG k hantavirusam. Neskol'ko pacientov byli napravleny na PCR-issledovanie RNK\DNK chetyreh kleschevyh infekciy: KE, KB, monocitarnogo erlihioza cheloveka (MECh) i granulocitarnogo anaplazmoza cheloveka (GACh). Rezul'taty i obsuzhdenie. Immunoglobuliny klassa M k hantavirusam naydeny u 5,4% bol'nyh s lihoradkoy neyasnoy etiologii, immunoglobuliny klassa G – v 2,2 %. U odnogo pacienta obnaruzheno odnovremennoe prisutstvie IgM i IgG. Vse pacienty otmechali razlichnye zhaloby: na povyshenie temperatury tela, slabost', porazheniya kozhnyh pokrovov, uvelichenie limfouzlov, boleznennost' sustavov i golovnuyu bol'. Issledovanie 48 obrazcov legkih ot mlekopitayuschih, otlovlennyh v Pribaykal'e v 2016 godu, pokazalo nalichie antigena hantavirusov v 6,3%. Zaklyuchenie. Cikl predyduschih i nastoyaschih issledovaniy dokazyvaet suschestvovanie prirodnyh ochagov hantavirusov v Pribaykal'e s real'noy opasnost'yu zabolevaniya naseleniya, prozhivayuschego na etoy territorii. Takim obrazom, nami ustanovleno, chto naselenie Pribaykal'ya krome kontaktov s kleschevymi infekciyami mozhet imet' kontakty s hantavirusami, antitela k kotorym vyyavleny u 6,5% pacientov s lihoradkoy nevyyasnennoy etiologii.
Vvedenie. Po oficial'noy statistike sredi prirodno-ochagovyh bolezney v Rossiyskoy Federacii zabolevaniya, vyzyvaemye hantavirusami, zanimayut odno iz pervyh mest. Material i metody. V rabote predstavleny rezul'taty issledovaniya 92 syvorotok krovi bol'nyh lyudey, obrativshihsya v Centr diagnostiki i profilaktiki kleschevyh infekciy FGBNU «Nauchnyy centr problem zdorov'ya sem'i i reprodukcii cheloveka» s zhalobami na uhudshenie sostoyaniya zdorov'ya. V zavisimosti ot srokov prisasyvaniya klescha ili predpolagaemogo ukusa klescha vsem pacientam byli provedeny serologicheskie i/ili PCR-issledovaniya na nalichie antigena/antitel IgM, IgG k virusu kleschevogo encefalita (KE), antitel IgM, IgG k kleschevomu borreliozu (KB), antitel IgM, IgG k hantavirusam. Neskol'ko pacientov byli napravleny na PCR-issledovanie RNK\DNK chetyreh kleschevyh infekciy: KE, KB, monocitarnogo erlihioza cheloveka (MECh) i granulocitarnogo anaplazmoza cheloveka (GACh). Rezul'taty i obsuzhdenie. Immunoglobuliny klassa M k hantavirusam naydeny u 5,4% bol'nyh s lihoradkoy neyasnoy etiologii, immunoglobuliny klassa G – v 2,2 %. U odnogo pacienta obnaruzheno odnovremennoe prisutstvie IgM i IgG. Vse pacienty otmechali razlichnye zhaloby: na povyshenie temperatury tela, slabost', porazheniya kozhnyh pokrovov, uvelichenie limfouzlov, boleznennost' sustavov i golovnuyu bol'. Issledovanie 48 obrazcov legkih ot mlekopitayuschih, otlovlennyh v Pribaykal'e v 2016 godu, pokazalo nalichie antigena hantavirusov v 6,3%. Zaklyuchenie. Cikl predyduschih i nastoyaschih issledovaniy dokazyvaet suschestvovanie prirodnyh ochagov hantavirusov v Pribaykal'e s real'noy opasnost'yu zabolevaniya naseleniya, prozhivayuschego na etoy territorii. Takim obrazom, nami ustanovleno, chto naselenie Pribaykal'ya krome kontaktov s kleschevymi infekciyami mozhet imet' kontakty s hantavirusami, antitela k kotorym vyyavleny u 6,5% pacientov s lihoradkoy nevyyasnennoy etiologii.
Keywords:
gemorragicheskaya lihoradka s pochechnym sindromom, hantavirusy, antigen hantavirusov, antitela k hantavirusam
gemorragicheskaya lihoradka s pochechnym sindromom, hantavirusy, antigen hantavirusov, antitela k hantavirusam
1. Spislit hantavirusnaya infekciya
