Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Izucheno vliyanie prirody organicheskogo rastvoritelya, rN sredy, nalichiya elektrolita, vremeni i kratnosti ekstrakcii na process izolirovaniya tofizopama iz model'noy smesi mochi. Ustanovleno, chto optimal'nym organicheskim rastvoritelem yavlyaetsya dihloretan c rN 5.0. Vysalivayuschim deystviem dlya tofizopama obladaet nasyschennyy rastvor natriya sul'fata. Maksimal'noe izolirovanie nablyudaetsya pri dvukratnoy ekstrakcii v techenie 7 minut. Ustanovleno, chto iz model'noy smesi mochi izoliruetsya ot 66,51 do 67,91 % tofizopama.
himiko-toksikologicheskiy analiz, izolirovanie, tofizopam
1. Arzamastsev AP, Sadchikova NP, Kharitonov YY. (2006). Validation of analytical methods [Validatsiya analiticheskikh metodov]. Farmatsiya, (4), 8-12. 2. State pharmacopeia [Gosudarstvennaya farmakopeya] (2015). Moskva, 1, 1470 p.
2. Gosudarstvennaya farmakopeya; 13-e. izd-e. - M., 2015. - T. 1. - 1470 s.
3. Register of medicines of Russia [Registr lekarstvennykh sredstv Rossii] (2010). Moskva, 1368 p.
4. Salomatin EM, Nikolaeva EG. (1999). Forensic chemical analysis of cadaveric material for drug and narcotic compounds [ Sudebno-khimicheskiy analiz trupnogo materiala na nalichie lekarstvennykh i narkoticheskikh soedineniy]. Sudebno-meditsinskaya ekspertiza, (3), 21-22.
5. Chernova LV. (1998). Using screening methods and their combination in chemical and toxicological analysis of medicinal substances of acid and basic nature [Primenenie skriningovykh metodov i ikh sochetaniy v khimiko-toksikologicheskom analize lekarstvennykh veshchestv kislotnogo i osnovnogo kharaktera]. Aktual’nye voprosy i ekspertnoy praktiki: Sbornik nauchnykh trudov. Novosibirsk, (3), 211-214.
