Moskva, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moskva, Moscow, Russian Federation
Izucheno vliyanie neblagopriyatnyh faktorov vneshney sredy na osnovnye parametry okislitel'nogo stressa u prakticheski zdorovyh ispytuemyh. Prakticheski zdorovye dobrovol'cy byli podvergnuty deystviyu iskusstvenno sozdannoy gipertermii. Cherez podelennye intervaly vremeni u uchastnikov issledovaniya opredelyali uroven' MDA v plazme krovi, aktivnost' klyuchevyh antioksidantnyh fermentov v eritrocitah. Posle 30 dney prebyvaniya v usloviyah gipertermii u ispytuemyh bylo vyyavleno statisticheski znachimoe uvelichenie soderzhaniya MDA (na 62 %), a takzhe snizhenie aktivnosti katalazy (na 11 %) i glutationperoksidazy (na 19 %).
aktivnye formy kisloroda, svobodnoradikal'noe okislenie, malonildial'degid , katalaza, glutationperoksidaza, superoksidismutaza
1. Lankin VZ, Konovalova GG, Tikhaze AK (2011). Influence of atherogenic aldehydes on antioxidant enzyme activity. [Vliyanie aterogennykh al’degidnykh soedineniy na aktivnost’ antioksidantnykh fermentov]. Kardiologicheskiy vestnik, 6 (2), 26-30.
2. Lankin VZ, Konovalova GG, Tikhaze AK, Nedosugova LV (2011). Glucose triggers atherogenic oxidative modification of low-density lipoproteins in vitro and in diabetic patients [Glyukoza initsiiruet aterogennuyu okislitel’nuyu modifikatsiyu lipoproteidov nizkoy plotnosti in vitro i u bol’nykh sakharnym diabetom tipa 2]. Kardiologicheskiy vestnik, 6 (1), 16-22.
3. Lankin VZ, Tikhaze AK, Belenkov YN (2004). Antioxidants in complex therapy of atherosclerosis: pro at contra [Antioksidanty v kompleksnoy terapii ateroskleroza: pro et contra]. Kardiologiya, 44 (2), 72-81.
4. Lankin VZ, Tikhaze AK, Belenkov YN (2001). Free-radical process in cardiovascular deseases [Svobodnoradikal’nye protsessy pri zabolevaniyakh serdechno-sosudistoy sistemy]. Kardiologiya, 40 (7), 48-61.
5. Lankin VZ, Tikhaze AK, Kapelko VI, Shepelkova GS, Shumaev KB, Panasenko OM, Konovalova GG, Belenkov YN (2007). Mechanism of oxidative modification of low-density lipoproteins in oxidative and carbonil stress [Mekhanizm okislitel’noy modifikatsii lipoproteidov nizkoy plotnosti pri okislitel’nom i karbonil’nom stresse]. Biokhimiya, 72 (10), 1330-1341.
6. Lankin VZ, Tikhaze AK, Kumskova EM (2012). Uptake of lipohydroperoxide-rich and malonyldialdehyde-modified low-density lipoproteins by human macrophages [Zakhvat kul’tiviruemymi monotsitami-makrofagami cheloveka lipoproteidov nizkoy plotnosti, obogashchennykh pervichnymi i vtorichnymi produktami svobodnoradikal’nogo okisleniya lipidov]. Kardiologicheskiy vestnik, 7 (1), 18-22.
7. Menshchikova EB, Zenkov NK, Lankin VZ, Bondar IA, Trufakin VA (2008). Oxidative stress. Pathologic conditions and diseases [Okislitel’nyy stress. Patologicheskie sostoyaniya i zabolevaniya], 284.
8. Menshchikova EB, Lankin VZ, Zenkov NK, Bondar IA, Krugovykh NF, Trufakin VA (2006). Oxidative stress. Prooxidants and antioxidants [Okislitel’nyy stress. Prooksidanty i antioksidanty], 556.
9. Tikhaze AK, Viygimaa MA, Konovalova GG, Kumskova EM, Abina E, Zemtsovskaya G, Yanushevskaya EV, Vlasik TN, Lankin VZ (2010). Relation between malondialdehyde-depended modification and content of cholesterol in low-density lipoproteins [Vzaimosvyaz’ mezhdu nalichiem malonildial’degid-zavisimoy modifikatsii i soderzhaniem kholesterina v lipoproteidakh nizkoy plotnosti]. Byulleten’ eksperimental’noy biologii i meditsiny, (2), 143-145.
10. Chernikov AV, Gudkov SV, Shtarkman IN, Bruskov VI (2007). Oxygen effect in DNA heat injury [ Kislorodnyy effekt pri teplovykh povrezhdeniyakh DNK]. Biofizika, 52 (2), 244-251.
11. Shtarkman IN, Gudkov SV, Chernikov AV, Bruskov VI (2008). Hydric dioxide and hydroxyl radical formation in water solutions of L-aminoacids in case of X-ray and heat impact [Obrazovanie perekisi vodoroda i gidroksil’nykh radikalov v vodnykh rastvorakh L-aminokislot pri vozdeystvii rentgenovskogo izlucheniya i tepla]. Biofizika, 53 (1), 1-14.
12. Lankin VZ (2003). The enzymatic systems in the regulation of free radical lipid peroxidation. In: A. Tomasi, T. Özben, V. Skulachev (eds.). Free radicals, nitric oxide, and inflammation: molecular, biochemical, and clinical aspects. NATO Science Series, (344), 8-23.
13. Lankin VZ, Tikhaze AK (2003). Atherosclerosis as a free radical pathology and antioxidative therapy of this disease. In: A. Tomasi, T. Özben, V. Skulachev (eds.). Free radicals, nitric oxide, and inflammation: molecular, biochemical, and clinical aspects. NATO Science Series, (344), 218-231.
14. Lankin VZ, Tikhaze AK, Konovalova GG. (2011). Aldehyde-dependent modification of low density lipoproteins. Handbook of Lipoprotein Research, 85-107.
