Sankt-Peterburg, St. Petersburg, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Sankt-Peterburg, St. Petersburg, Russian Federation
Cel'yu raboty stalo sravnenie stepeni okislitel'nyh povrezhdeniy makromolekul, a takzhe ocenka sostoyaniya antioksidantnoy sistemy pri hronicheski povyshennom soderzhanii gomocisteina v plazme krovi u vzroslyh zhivotnyh i u krysyat, prenatal'noe razvitie kotoryh protekalo v usloviyah gipergomocisteinemii (GGC). Pri vozdeystvii GGC na vzroslyh zhivotnyh tak zhe, kak i v otdalennom periode, posle prenatal'noy GGC proishodit povyshennoe obrazovanie nitrotirozina, a takzhe izmenenie aktivnosti superoksoddismutazy.
gipergomocisteinemiya, okislitel'nyy stress, superoksiddismutaza
1. Fujimura M, Morita-Fujimura Y, Noshita N, Sugawara T, Kawase M, Chan PH (2000). The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci., 20 (8), 2817-2824.
2. Ganguly P, Alam SF (2015). Role of homocysteine in the development of cardiovascular disease. Nutr. J., 14 (6), doi:https://doi.org/10.1186/1475-2891-14-6.
3. Hooijmans CR, Blom HJ, Oppenraaij-Emmerzaal D, Ritskes-Hoitinga M, Kiliaan AJ (2009). S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice. Neurol. Sci., 30 (5), 439-445.
4. Koz ST, Gouwy NT, Demir N, Nedzvetsky VS, Etem E, Baydas G (2010). Effects of maternal hyperhomocysteinemia induced by methionine intake on oxidative stress and apoptosis in pup rat brain. Int. J. Dev. Neurosci., 28 (4), 325-329.
5. Kulkarni-Narla A, Getchell TV, Getchell ML (1997). Differential expression of manganese and copper-zinc superoxide dismutases in the olfactory and vomeronasal receptor neurons of rats during ontogeny. J. Comp. Neurol., 381 (1), 31-40.
6. Murphy MM, Scott JM, Arija V (2004). Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight. Clin. Chem., (50), 1406-1412.
7. Perna AF, Ingrosso D, Lombardi C, Acanfora F, Satta E, Cesare CM, Violetti E, Romano MM, De Santo NG (2003). Possible mechanisms of homocysteine toxicity. Kidney Int. Suppl., (84), S137-S140
8. Pustygina AV, Milyutina YP, Zaloznyaya IV, Arutyunyan AV (2015). Indices of oxidative stress in the brain of newborn rats subjected to prenatal hyperhomocysteinemia. Neurochem. J., 9 (1), 60-65.
9. Shim SY, Kim HS (2013). Oxidative stress and the antioxidant enzyme system in the developing brain. Korean J. Pediatr., 56 (3), 107-111.
10. Shivakumar BR, Anandatheerthavarada HK, Ravindranath V (1991). Free radical scavenging systems in developing rat brain. Int. J. Dev. Neurosci., 9 (2), 181-185.
11. Tsitsiou E, Sibley CP, D’Souza SW, Catanescu O, Jacobsen DW, Glazier JD (2011). Homocysteine is transported by the microvillous plasma membrane of human placenta. J. Inherit. Metab. Dis., 34 (1), 57-65.
12. Upchurch GR Jr., Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr., Loscalzo J (1997). Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem., (272), 17012-17017.
13. Wells PG, Winn LM (1996). Biochemical toxicology of chemical teratogenesis. Crit. Rev. Biochem. Mol. Biol., 31 (1), 1-40.
14. Zhang X, Li H, Jin H, Ebin Z, Brodsky S, Goligorsky MS (2000). Effects of homocysteine on endothelial nitric oxide production. Am. J. Physiol. Renal Physiol., (279), 671-678.
