employee
Moscow, Russian Federation
UDK 61 Медицина. Охрана здоровья
GRNTI 76.03 Медико-биологические дисциплины
GRNTI 76.33 Гигиена и эпидемиология
OKSO 14.04.02 Ядерные физика и технологии
OKSO 31.06.2001 Клиническая медицина
OKSO 32.08.12 Эпидемиология
OKSO 31.08.08 Радиология
BBK 51 Социальная гигиена и организация здравоохранения. Гигиена. Эпидемиология
BBK 534 Общая диагностика
TBK 5708 Гигиена и санитария. Эпидемиология. Медицинская экология
TBK 5712 Медицинская биология. Гистология
TBK 5734 Медицинская радиология и рентгенология
TBK 6212 Радиоактивные элементы и изотопы. Радиохимия
Privedennoe vyshe pis'mo predstavlyaet soboy otklik na nashe opublikovannoe v 2016 g. v «Medicinskaya radiologiya i radiacionnaya bezopasnost'» issledovanie (pooled-analiz) chastoty perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy (SchZh) dlya grupp lyudey iz razlichnyh stran mira (SNG – Rossiya, Belorussiya i Ukraina; Evropa, SShA + Kanada i Aziatsko-Tihookeanskiy region) v raznye periody posle avarii na Chernobyl'skoy atomnoy elektrostancii (ChAES).
gennye perestroyki RET/PTC, papillyarnaya karcinoma schitovidnoy zhelezy, sverhocenka posledstviy chernobyl'skoy avarii
Приведенное выше письмо представляет собой отклик на наше опубликованное в 2016 г. в «Медицинская радиология и радиационная безопасность» исследование (pooled-анализ) частоты перестроек RET/PTC в папиллярных карциномах щитовидной железы (ЩЖ) для групп людей из различных стран мира (СНГ – Россия, Белоруссия и Украина; Европа, США + Канада и Азиатско-Тихоокеанский регион) в разные периоды после аварии на Чернобыльской атомной электростанции (ЧАЭС). Аналогичное письмо-отклик С.В. Яргина на нашу соответствующую работу 2016 г. по зависимостям доза–эффект для частоты RET/PTC было уже опубликовано в журнале «Радиационная биология. Радиэкология». Сходное письмо этого же автора направлялось в 2016 г. также и в «Саратовский научно-медицинский журнал» в ответ на нашу уже давнюю статью от 2013 г. по анализу частоты RET/PTC для радиобиологии и эпидемиологии. Это письмо С.В. Яргина журналом пока не опубликовано. Все «отклики» С.В. Яргина в целом аналогичны, развивают одни и те же представления («гипотезу», согласно его словам) и, местами, просто идентичны (смысл же и основные ссылки также во многом идентичны). Рассматриваемые проблемы являются узкими, специальными и, по внешнему виду, мало о чем могут говорить тому, кто не занимается именно генными перестройками RET/PTC.
1. Koterov A.N., Ushenkova L.N., Biryukov A.P., Samoylov A.S. Chastota gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy v stranah mira v zavisimosti ot vremeni posle avarii na Chernobyl'skoy atomnoy elektrostancii (pooled-analiz) // Med. radiol. i radiac. bezopasnost'. 2016. T. 61. № 2. S. 5-19.
2. Koterov A.N., Ushenkova L.N., Biryukov A.P., Samoilov A.S. RET/PTC gene rearrangements frequency in papillary thyroid carcinoma worldwide depending on time after Chernobyl Nuclear Power Plant accident (pooled-analysis). Possible contribution of factors of diagnosis, ‘aggressive surgery’, radiation and age // Med. radiol. i radiac. bezopasnost'. 2016. T. 61. № 5. S. 27-41.
3. Koterov A.N., Ushenkova L.N., Biryukov A.P. Zavisimosti doza-effekt dlya chastoty gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy posle oblucheniya. Ob'edinennyy analiz radiacionno-epidemiologicheskih dannyh // Radiac. biologiya. Radioekologiya. 2016. T. 56. № 1. S. 5-25.
4. Yargin S.V. Otklik na stat'yu: Koterov A.N., Ushenkova L.N., Biryukov A.P. Zavisimosti doza-effekt dlya chastoty gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy posle oblucheniya // Radiac. biologiya. Radioekologiya. 2016. T. 56. № 5. S. 542-544.
5. Ushenkova L.N., Koterov A.N., Biryukov A.P. Nepolnoe sootvetstvie eksperimental'nyh i epidemiologicheskih dannyh dlya chastoty gennoy perestroyki RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy primenitel'no k avarii na Chernobyl'skoy AES // Saratovskiy nauchno-med. zhurnal. 2013. T. 9. № 4. S. 795-801.
6. Yargin S.V. O preuvelichenii radiacionnyh posledstviy avarii na Chernobyl'skoy AES // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 1. S. 73-74.
7. Yargin S.V. O preuvelichennyh posledstviyah avarii na ChAES: opuholi mochevogo puzyrya // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 4. S. 83-84.
8. Yargin S.V. Nedostovernye publikacii o radiacionnom kancerogeneze v rayone Semipalatinska // Med. radiol. i radiac. bezopasnost'. 2007. T. 52. № 5. S. 73-74.
9. Yargin S.V. Preuvelichennaya ocenka medicinskih posledstviy povysheniya radiacionnogo fona // Med. radiol. i radiac. bezopasnost'. 2008. T. 53. № 3. S. 17-22.
10. Yargin S.V. O zavyshennoy ocenke zabolevaemosti rakom schitovidnoy zhelezy sredi lic, podvergshihsya v detskom vozraste radioaktivnomu oblucheniyu pri avarii na ChAES // Med. radiol. i radiac. bezopasnost'. 2010. T. 55. № 2. S. 65-69.
11. Yargin S.V. Lesnye pozhary v zagryaznennyh zonah // Med. radiol. i radiac. bezopasnost'. 2011. T. 56. № 3. S. 69-73.
12. Yargin S.V. K voprosu o zavyshennoy ocenke medicinskih posledstviy avarii na ChAES: prichiny i mehanizmy // Med. radiol. i radiac. bezopasnost'. 2011. T. 56. № 5. S. 74-79.
13. Yargin S.V. O radiacionno-inducirovannyh mutaciyah: otvet Yu.E. Dubrove // Med. radiol. i radiac. bezopasnost'. 2014. T. 59. № 4. S. 73-77.
14. Koterov A.N. Po povodu stat'i professora Yu. Dubrova «Izgnanie besov iz radiacionnoy biologii» (minisatellity) // Med. radiol. i radiac. bezopasnost'. 2005. T. 50. № 4. S. 60-73.
15. Koterov A.N. Radiacionno-inducirovannaya nestabil'nost' genoma pri deystvii malyh doz radiacii v nauchnyh publikaciyah i v dokumentah mezhdunarodnyh organizaciy poslednih let // Med. radiol. i radiac. bezopasnost'. 2009. T. 54. № 4. S. 5-13.
16. Jargin S.V. On the causes of insufficient restroom environmental hygiene in the former Soviet Union // Rev. Inst. Med. Trop. Sao Paulo. 2009. Vol. 51. № 6. P. 353.
17. Jargin S.V. On the RET rearrangements in Chernobyl-related thyroid cancer // J. Thyroid Res. 2012. Vol. 2012. Article ID 373879.
18. Jargin SV. Chernobyl-related cancer and precancerous lesions: incidence increase vs. late diagnostics //Dose Response. 2014. Vol. 12. № 3. P. 404-414.
19. Jargin S.V On the RET/PTC3 rearrangements in Chernobyl related thyroid cancer vs. late detection // International Journal of Cancer Research and Molecular Mechanisms. Int. J. Cancer Res. Mol. Mech. 2015. Vol. 1 (4): http://dx.doi.org/10.16966/2381-3318.117.
20. Yargin S.V. Zavisimost' gennyh perestroek RET/PTC v papillyarnyh karcinomah schitovidnoy zhelezy ot dlitel'nosti zabolevaniy i opuholevoy progressii // Mater. konf. «Aktual'nye problemy radiobiologii i astrobiologii. Geneticheskie i epigeneticheskie effekty ioniziruyuschih izlucheniy», Dubna, 9-11 noyabrya 2016 g. Dubna, 2016. S. 81-82.
21. Nikiforov Y.E., Rowland J.M., Bove K.E. et al. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children // Cancer Res. 1997. Vol. 57. № 9. P. 1690-1694.
22. Romei C., Elisei R. RET/PTC translocations and clinico-pathological features in human papillary thyroid carcinoma // Front. Endocrinol. 2012. Vol. 3. Article 54. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356050/pdf/fendo-03-00054.pdf; data obrascheniya 12.01.2015).
23. Menicali E., Moretti S., Voce P. et al. Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma // Front. Endocrinol (Lausanne). 2012. Vol. 3. Article 67. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357465/pdf/fendo-03-00067.pdf; data obrascheniya 12.01.2015).
24. Ushenkova L.N., Koterov A.N., Biryukov A.P. Ob'edinennyy (pooled) analiz chastoty gennyh perestroek RET/PTC v spontannyh i radiogennyh papillyarnyh karcinomah schitovidnoy zhelezy // Radiac. biologiya. Radioekologiya. 2015. T. 55. № 4. S. 355-388.
25. Su X., Li Z., He C. et al. Radiation exposure, young age, and female gender are associated with high prevalence of RET/PTC1 and RET/PTC3 in papillary thyroid cancer: a meta-analysis // Oncotarget. 2016. Vol. 7. № 13. P. 16716-16730.
26. Ushenkova L.N., Koterov A.N., Biryukov A.P. Gennye perestroyki RET/PTC v spontannyh i radiogennyh opuholyah schitovidnoy zhelezy: molekulyarnaya genetika, radiobiologiya i molekulyarnaya epidemiologiya // Radiac. biologiya. Radioekologiya. 2015. T. 55. № 3. S. 229-249.
27. Yip L., Nikiforova M.N., Yoo J.Y. et al. Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients // Ann. Surg. 2015. Vol. 262. № 3. P. 519-525.
28. Hofmann B., Holm S., Iversen J.-G. Philosophy of science // In: ‘Research methodology in the medical and biological sciences’. Ed. by P. Laake, H.B. Benestad, B.R. Olsen. - Academic Press, Elsevier, 2007. P. 1-32.
29. Lushnikov E.F., Vtyurin B.M., Cyb A.F. Mikrokarcinoma schitovidnoy zhelezy. - M: Medicina, 2003. 264 s.
30. Viglietto G., Chiappetta G., Marchinez-Tello F.J. et al. RET-PTC oncogene activation is an early event in thyroid carcinogenesis // Oncogene. 1995. Vol. 11. № 6. P. 1207-1210.
31. Tallini G., Santoro M., Helie M. et al. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes // Clin Cancer Res. 1998. Vol. 4. № 2. P. 287-294.
32. Sugg S.L., Ezzat Sh., Rosen I.B. et al. Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia // J. Clin. Endocrinol. Metab. 1998. Vol. 83. № 11. P. 4116-4122.
33. Corvi R., Martinez-Alfaro M., Harach H.R. et al. Frequent RET rearrangements in thyroid papillary microcarcinoma detected by interphase fluorescence in situ hybridization // Lab. Invest. 2001. Vol. 81. № 12. P. 1639-1645.
34. Zhang T., Lu Y., Ye Q. et al. An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma // Genes Chromosomes Cancer. 2015. Vol. 54. № 3. P. 168-176.
35. Nikiforov Y.E., Nikiforova M.N. Molecular genetics and diagnosis of thyroid cancer // Nat. Rev. Endocrinol. 2011. Vol. 7. № 10. P. 569-580.
36. Mayr B., Brabant G., Goretzki P. et al. ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? // J. Clin. Endocrinol. Metab. 1997. Vol. 82. № 4. P. 1306-1367.
37. Soares P., Fonseca E., Wynford-Thomas D., Sobrinho-Simoes M. Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms? // J. Pathol. 1998. Vol. 185. № 1. P. 71-78.
38. Mochizuki K., Kondo T., Nakazawa T. et al. RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components // Histopathology. 2010. Vol. 57. № 3. P. 444-450.
39. Rabes H.M., Demidchik E.P., Sidorow J.D. et al. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Shernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications // Clin. Cancer Res. 2000. Vol. 6. № 3. P. 1093-1103.
40. Bongarzone I., Vigneri P., Mariani L. et al. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features // Clin. Cancer Res. 1998. Vol. 4. № 1. P. 223-228.
41. Rhoden K.J., Johnson C., Brandao G. et al. Real-time quantitative RT-PCR identifies distinct c-RET, RET/PTC1 and RET/PTC3 expression patterns in papillary thyroid carcinoma // Lab. Invest. 2004. Vol. 84. № 12. P. 1557-1570.
42. Jargin S.Vol. Thyroid cancer after chernobyl: obfuscated truth // Dose Response. 2011. Vol. 9. № 4. P. 471-476.
43. Nikiforov Y.E. Molecular diagnostics of thyroid tumors // Arch. Pathol. Lab. Med. 2011. Vol. 135. № 5. P. 569-577.
44. Rao P.J., Vardhini N.V., Parvathi M.V. et al. Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters // Tumour Biol. 2014. Vol. 35. № 10. P. 9539-9548.
45. Di Cristofaro J., Vasko V., Savchenko V. et al. ret/PTC1 and ret/PTC3 in thyroid tumors from Chernobyl liquidators: comparison with sporadic tumors from Ukrainian and French patients // Endocr. Relat. Cancer. 2005. Vol. 12. № 1. P. 173-183.
46. Henderson Y.C., Shellenberger T.D., Williams M.D. et al. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma // Clin. Cancer Res. 2009. Vol. 15. № 2. P. 485-491.
47. Moses W., Weng J., Khanafshar E. et al. Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentation // Surg. Res. 2010. Vol. 160. № 2. P. 179-183.
48. Cinti R., Yin L., Ilc K. et al. RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH // Cytogenet. Cell Genet. 2000. Vol. 88. № 1-2. P. 56-61.
49. Elisei R., Romei C., Vorontsova T. et al. RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults // J. Clin. Endocrinol. Metab. 2001. Vol. 86. № 7. P. 3211-3216.
50. Basolo F., Giannini R., Monaco C. et al. Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma // Am. J. Pathol. 2002. Vol. 160. № 1. P. 247-254.
51. Guerra A., Marotta V., Di Stasi V. et al. Simultaneous occurrence of BRAF mutation and RET/PTC rearrangement is frequent in papillary thyroid carcinoma // Endocrine Abstracts. 2012. Vol. 29. P1787.
52. Guerra A., Zeppa P., Bifulco M., Vitale M. Concomitant BRAF(V600E) Mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma // Thyroid. 2014. Vol. 24. № 2. P. 254-259.
53. Hershman J.M. Concomitant BRAF Mutation and RET/PTC rearrangement occur in 19 % of papillary thyroid cancers // Clinical Thyroidology. 2014. Vol. 26. № 4. P. 109-110.
54. Kitamura Y., Minobe K., Nakata T. et al. RET/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan // J. Hum. Genet. 1999. 44. № 2. P. 96-102.
55. Zhu X.L., Zhou X.Y., Zhu X.Z. BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma // Zhonghua Bing Li Xue Za Zhi. 2005. Vol. 34. № 5. P. 270-274.
56. Zhu Z., Ciampi R., Nikiforova M.N. et al. Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity // J. Clin. Endocrinol. Metab. 2006. Vol. 91. № 9. P. 3603-3610.
57. Liu R.-T., Chou F.-F., Wang C.-H. et al. Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese // Thyroid. 2005. Vol. 15. № 4. P. 326-335.
58. Wiench M., Wloch J., Oczko M. et al. Rearrangement of the RET gene in papillary thyroid carcinoma // Wiad. Lek. 2001. Vol. 54. Suppl 1. P. 64-71.
59. Erdogan M., Berdeli A., Karadeniz M. et al. The prevalence of RET/PTC mutations in papillary thyroid cancers in Turkish population and its relation between tumor histopathology and prognostic factors // Exp. Clin. Endocrinol. Diabetes. 2008 Vol. 116. № 4. P. 225-230.
60. UNSCEAR 2008. Report to the General Assembly, with Scientific Annex. Annex D. Health effects due to radiation from the Chernobyl accident. United Nations. New York, 2011. P. 47-219.
61. Likhtarov I., Kovgan L., Vavilov S. et al. Post-Chornobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses // Radiat. Res. 2005. Vol. 163. № 2. P. 125-136.
62. Likhtarov I., Thomas G., Kovgan L. et al. Reconstruction of individual thyroid doses to the Ukrainian subjects enrolled in the Chernobyl Tissue Bank // Radiat. Prot. Dosimetry. 2013. Vol. 156. № 4. P. 407-423.
63. Jacob P., Bogdanova T., Buglova E. et al. Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident // Radiat. Res. 2006. Vol. 165. № 1. P. 1-8.
64. Drozdovitch V., Minenko V., Khrouch V. et al. Thyroid dose estimates for a cohort of Belarusian children exposed to radiation from the Chernobyl accident // Radiat. Res. 2013. Vol. 179. № 5. P. 597-609.
65. Finn S.P., Smyth P., O’regan E. et al. Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes // Virchows Arch. 2004. Vol. 445. № 4. P. 396-404.
66. Caudill C.M., Zhu Z., Ciampi R. et al. Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation // J. Clin. Endocrinol. Metab. 2005. Vol. 90. № 4. P. 364-369.
67. Yargin S.V. K voprosu o preuvelichenii posledstviy avarii na Chernobyl'skoy AES // Molodoy uchenyy. 2015. № 3. S. 351-358.
68. Prescott J.D., Zeiger M.A. The RET oncogene in papillary thyroid carcinoma // Cancer. 2015. Vol. 121. № 13. P. 2137-2146.
69. Rabes H. Gene Rearrangements in Radiation-Induced Thyroid Carcinogenesis // Med Pediatr Oncol. 2001. Vol. 36. № 5. P. 574-582.
70. Romei C., Fugazzola L., Puxeddu E. et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years // J. Clin. Endocrinol. Metab. 2012. Vol. 97. № 9. P. E1758-E1765.
71. Agate L., Lorusso L., Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors // J. Endocrinol. Invest. 2012. Vol. 35. № 6. P. 3-9.
72. Jung C.K., Little M.P., Lubin J.H. et al. The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations // J. Clin. Endocrinol. Metab. 2014. Vol. 99. № 2. P. E276-E285.
73. Jargin S.V. On the tumor risk from dental diagnostic X-ray exposure // Ann. Oncol. 2016. Vol. 27. № 6. P. 1177.
74. Lin M.C., Lee C.F., Lin C.L. et al. Dental diagnostic X-ray exposure and risk of benign and malignant brain tumors // Ann. Oncol. 2013. Vol. 24. № 6. P. 1675-1679.
75. Hallquist A., Hardell L., Degerman A. et al. Medical diagnostic and therapeutic ionizing radiation and the risk for thyroid cancer: a case-control study // Eur. J. Cancer Prev. 1994. Vol. 3. № 3. P. 259-267.
76. Hallquist A., Nasman A. Medical diagnostic X-ray radiation--an evaluation from medical records and dentist cards in a case-control study of thyroid cancer in the northern medical region of Sweden // Eur. J. Cancer Prev. 2001. Vol. 10. № 2. P. 147-152.
77. Memon A., Godward S., Williams D. et al. Dental x-rays and the risk of thyroid cancer: a case-control study // Acta Oncol. 2010. Vol. 49. № 4. P. 447-453.
78. Hallquist A., Jansson P. Self-reported diagnostic X-ray investigation and data from medical records in case-control studies on thyroid cancer: evidence of recall bias? // Eur. J. Cancer Prev. 2005. Vol. 14. № 3. P. 271-276.
79. Kitahara C.M., Linet M.S., Rajaraman P. et al. A New Era of Low-Dose Radiation Epidemiology // Curr. Environ. Health Rep. 2015. Vol. 2. № 3. P. 236-249.