The review deals with the analysis of modern methods of treatment of chronic generalized parodontitis from the perspective of differentiated principle of treatment of this disease. Particular attention is paid to methods of medical treatment, their diversity on the efficiency and mechanisms of therapeutic effects to select appropriate treatment, taking into account all the individual characteristics of the patient, aetiology, pathogenesis and severity of chronic generalized parodontitis. It has been demonstrated that an important aspect to achieve high efficiency of treatment is a method of drug delivery. The most effective method is a transmembrane dialysis, which makes it possible simultane-ously to obtain the maximum concentration of the therapeutic substances in the inflammatory focus and to eliminate from the inflammatory focus the low-medium weight tissue decomposition products, products of metabolism, while maintaining factors of regeneration and protection against infection. It has been evinced the advantages of sanogenetic therapy using vitamin cocktail and some higher plants BAS containing terpenoids (bornylacetate and its semisynthetic stereoisomer – isobornyl acetate), as the least toxic, having analgesic and anti-bacterial properties comparable with antibiotics, and capable to stimulate repair processes. The good water solubility of these substances provides ample pos-sibility of using these drugs in the form of solutions for rinsing, transmembrane dialysis, as liquid at ultrasonic curettage.
chronic generalized parodontitis, medicamental therapy, sanogenetic therapy
1. AlimskiyAV (2011). Organizational aspects of periodontal dental care [Organizatsionnye aspekty parodontologicheskoy stomatologicheskoy pomoshchi naseleniyu]. Ekonomika i menedzhment v stomatologii, (3), 20-21
2. BalinVN, IordanishviliAK, KovalevskiyAM,AvetisyanAY (2006). The use of herbal remedies for the treatment of periodontal disease [Primenenie fitopreparatov dlya lecheniya patologii parodonta]. Parodontologiya, (1), 1-4.
3. .BolshedvorskayaNE, KazankovaEM, TirskayaOI, MolchanovAN, VasilyevaLS, MolokovVD (2005).Pathogenetic significance of the periodontal structural features of rats with periodontitis [Patogeneticheskoe znachenie strukturnykh osobennostey parodonta u krys pri parodontite]. Palliativnaya meditsina i reabilitatsiya, (2), 95a.
4. .BolshedvorskayaNE, VasilyevaLS, MolokovVD (2011). Morphological characteristics of periodont for treatment of experimental periodontitis by using antibacterial adhesive composition “Sulfakrilat” [Morfologicheskaya kharakteristika parodonta pri lechenii eksperimental’nogo parodontita s pomoshch’yu antibakterial’noy kleevoy kompozitsii «Sul’fakrilat»]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 100 (1), 26-30.
5. .BondarenkoVM (2013). New horizons for bacte-riophage therapy [Novye gorizonty bakteriofagotera-pii]. Byull. Orenburgskogo nauchnogo tsentra UrO RAN (elektronnyy zhurnal), (4), 10-12.
6. GrudyanovAI, Ovchinnikova VV, DmitrievaHA.(2004). Anti-microbial and anti-inflammatory therapy in periodontics [Antimikrobnaya i protivovospalitel’naya terapiya v parodontologii], 80.
7. GrudyanovA, FomenkoE (2013). Methods of con-servative treatment of inflammatory periodontal dis-eases [Metody konservativnogo lecheniya vospalitel’nykh zabolevaniy parodonta], 88.
8. .DorzhievaZV, SpasovaOO (2008). The role of cytokines in the regulation of inflammation of periodontal tissue in patients with diabetes type 2 [Rol’ tsitokinov v regulyatsii vospaleniya tkaney parodonta u bol’nykh sakharnym diabetom 2-go tipa]. Rossiyskiy stomatologicheskiy zhurnal, (6), 28-29.
9. KazankovaEM, Vasil’evaLS, MolokovVD(2004). Treatment of experimental periodontitis by transmembrane dialysis of vitamin complex [Lechenie eksperimental’nogo parodontita putem transmembrannogo dializa kompleksa vitaminov]. Sovremennye naukoemkie tekhnologii, (6), 92.
10. KazaryanNS, KozlovKK, BykovAY (2013). The role and method of use of proteolytic enzymes in the treatment of purulent wounds [Rol’ i sposob primeneniya proteoliticheskikh fermentov v protsesse lecheniya gnoynykh ran]. Omskiy nauchnyy vestnik, 2(124), 20-21.
11. .KiselnikovaLP (2008). The role of antibiotic therapy and antibiotic prophylaxis in treatment of periodontal diseases [Rol’ antibiotikoterapii i antibiotiko-profilaktiki v kompleksnom lechenii zabolevaniy parodonta]. Stomatolog, (3), 19-22
12. Klyushnikova MO, Molokov VD, Balakhonov SV (2007). The prevalence of different genotypes of strains of Actinobacillus Actinomycetemcomitans in patients with inflammatory periodontal diseases [Rasprostranen-nost’ razlichnykh genotipov shtammov Actinobacillus Actinomycetemcomitans u bol’nykh s vospalitel’nymi zabolevaniyami parodonta]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 69 (2), 91-93.
13. KlyushnikovaMO, MolokovVD, KlyushnikovaON (2010). Experience in the use of ozone therapy in the treatment of chronic generalized periodontitis [Opyt primeneniya ozonaterapii v lechenii khronicheskogo generalizovannogo parodontita]. Yakutskiy meditsinskiy zhurnal, (1), 111-112.
14. KrazhanDS, GarazhaNN, OrlovMN, MorgoevaZZ(2012). Potentiated action of antiseptics and sorbents on the microflora of periodontal pockets [Potentsirovannoe deystvie antiseptikov i sorbentov na mikrofloru parodontal’nykh karmanov]. Meditsinskiy vestnik Severnogo Kavkaza,(2), 40-42.
15. KulikovLK, KazankovSS, PrivalovYA, SobotovichVF, SmirnovAA, GarmashovVI (2014). The dynamics of biochemical parameters of granulation tissue of experimental infected wounds in the treatment by biologically active drugs [Dinamika biokhimicheskikh pokazateley granulyatsionnoy tkani eksperimental’nykh infitsirovannykh ran pri lechenii biologicheski aktivnymi preparatami]. Novosti khirurgii, 22(4), 395-402.
16. .KurganovaVA, Vasil’evaLS, MolokovVD (2006).Experimental and clinical study of the treatment of periodontitis by transmembrane dialysis of succinic acid and vitamins B1, PP, C [Eksperimental’noe i klinicheskoe issledovanie lecheniya parodontita transmembrannym dializom yantarnoy kisloty i vitaminov V1, RR, S]. Sibirskiy meditsinskiy zhurnal (Irkutsk),64(6), 26-29.
17. Kuchin AV. (2005). Synthesis of new terpenoids - potential drugs for the treatment of oncological diseases [Sintez novykh terpenoidov - potentsial’nykh lekarstvennykh preparatov dlya lecheniya onkologicheskikh zabolevaniy]. Novye lekarstvennye sredstva: uspekhi i perspektivy, 10-12
18. LatserusLA, BerezovskayaIV, RymartsevVI, Pinigi-naNM (2010). Study of common toxicity of the drug Abisilin for oral use [Izuchenie obshchetoksicheskogo deystviya preparata Abisilin dlya peroral’nogo primeneniya]. Rossiyskiy bioterapevticheskiy zhurnal,9(1), 35-38
19. LacerusLA (2010). Application of the terpenoid-containing drug Abisilin in the treatment and prevention of surgical infection [Primenenie terpenoidsoderzhashchego preparata Abisil v lechenii i profilaktike khirurgicheskoy infektsii]. Rossiyskiy bioterapevticheskiy zhurnal, 9(1), 39-41.
20. MolokovVD, Vasil’evaLS, TirskayaOI, Kal’kEA (2009). The effectiveness of linkomitcin dialysis influence on the periodontal pocket microflora of in patients with mild and severe forms of chronic generalized periodontitis [Effektivnost’ vliyaniya dializa linkomitsina na mikrofloru parodontal’nogo karmana u bol’nykh khronicheskim generalizovannym parodontitom legkoy i sredney stepeni tyazhesti]. Sibirskiy meditsinskiy zhurnal (Irkutsk), (8), 19-21
21. MolokovVD, Bol’shedvorskayaNE (2011). The method of application of the adhesive composition “Sulfacrylate” and assessment of its clinical efficacy in treatment of periodontitis [Metodika primeneniya kleevoy kompozitsii «Sul’fakrilat» i otsenka ee klinicheskoy effektivnosti v kompleksnom lechenii parodontita]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 100(1), 172-175.
22. MolchanovAN, Vasil’evaLS, MolokovVD (2004). The effectiveness of treatment of experimental periodontitis using the integrated application of the laser radiation and the glycine dialysis [Effektivnost’ lecheniya eksperimental’nogo parodontita s pomoshch’yu kompleksnogo primeneniya lazernogo izlucheniya i dializa glitsina]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 42(1), 62-65.
23. GoncharovaEI et al. (eds). (2006). Preparations of medicinal plants in the dental practice [Preparaty lekarstvennykh rasteniy v stomatologicheskoy praktike: uchebnoe posobie], 45.
24. At’kovOY, KamenskikhVM, BesyakovVR (eds). (2010). Plans for the management of patients. Stomatology. [Plany vedeniya bol’nykh. Stomatologiya], 240
25. RalduginVA (2004). Fir triterpenoids and highly effective regulator of plant growth on their basis [Triterpenoidy pikhty i vysokoeffektivnyy regulyator rosta rasteniy na ikh osnove]. Ros. khim. zhurnal: (Zh. Ros. Khim. ob-va im. D.I. Mendeleeva), XLVIII (3), 84-88.
26. BarerGM (ed.) (2014). Therapeutic dentistry: a textbook. In 3 parts. Part 2. Periodontal disease. [Terapevticheskaya stomatologiya: uchebnik. V 3-kh ch. Chast’ 2. Bolezn’ parodonta], 224.
27. TomiloIV, MolokovVD (2006). Physico-chemical properties of drugs included in the drug composition for the treatment of inflammatory periodontal diseases [Fiziko-khimicheskie svoystva lekarstvennykh preparatov, vkhodyashchikh v sostav lekarstvennoy kompozitsii, dlya lecheniya vospalitel’nykh zabolevaniy parodonta]. Nauka i obrazovanie, (2), 88-92.
28. .UsovaNF (2013). Inflammatory periodontal diseases: pathogenesis, principles of complex treatment [Vospalitel’nye zabolevaniya parodonta: patogenez, printsipy kompleksnogo lecheniya]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 116(1), 141-144.
29. UsovaNF, FedoseevaGM, SkibinaEV (2010). Experience of prolonging of the therapeutic effect of herbal remedies in the treatment of gingivitis and periodontitis [Opyt prolongirovaniya terapevticheskogo vozdeystviya fitopreparatov v lechenii gingivita i parodontita]. Sibirskiy meditsinskiy zhurnal (Irkutsk), 95(4), 105-106.
30. UshakovRV, GrudyanovAI, ChuhodzhanGA (2000). Application of adhesive films drugs «Diplen-Denta» for dentistry [Primenenie adgezivnykh lekarstvennykh plenok «Diplen-Denta» v stomatologii]. Parodontologiya, 17(3), 13-16
31. VolfGF, HehsselTM (2014). Periodontics. Hygienic aspects [Parodontologiya. Gigienicheskie aspekty], 360.
32. TsepovLM, NikolaevAI, MikheevaEA (2008). Diagnostics, treatment and prevention of periodontal diseases [Diagnostika, lechenie i profilaktika zabolevaniy parodonta], 272.
33. TsepovLM, NakonechnyjDA, GolevaNA,NesterovaMM, KojfmanOB (2012). Photodynamic therapy in the complex treatment of periodontitis (clinical observation) [Fotodinamicheskaya terapiya v kompleksnom lechenii parodontita (klinicheskoe nablyudenie)]. Parodontologiya, 17(2), 54-57.
34. TsepovLM, NikolaevAI, NesterovaMM, Shcherba-kovaTE (2012). “Borderline states” in the diagnostics and treatment of inflammatory periodontal diseases [«Pogranichnye sostoyaniya» v diagnostike i lechenii vospalitel’nykh zabolevaniy parodonta]. Parodontologiya, 17(4), 8-12.
35. TsepovLM, MikheevaEA, GolevaNA, NesterovaMM. (2010). Chronic generalized periodontitis: remarks to the modern ideas [Khronicheskiy generalizovannyy parodontit: remarki k sovremennym predstavleniyam].Parodontologiya, 15 (1), 3-7
36. AdamsVR, DeremberDL, StevichB, MattinglyCA, GalltB, SubramanianT, TroutmanJM, SpielmannHP (2010). Anticancer activity of novel unnatural synthetic isoprenoids. Anticancer Res., 30(7), 2505-2512.
37. HassanSB, Gali-MuhtasibH, GoranssonH, LarssonR (2010). Alpha-terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signaling. Anticancer Res., 30(6), 1911-1919.
38. LageH, DuarteN, CoburgerC, HilgerothA, FerreiraMJ (2010). Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Phytomedicine, 17(6), 441-448.
39. LambertHR (2007). New age periodontics: what’s coming down the pike. Dentistry Today, 26(70), 72-73.
40. LiorC, CotsJM, GasparM, Alay M, Rams N (2009). Antibiotic prescription over the last 16 years: fewer antibiotics but the spectrum is broadening. Eur. J. Clin. Microbial Infect. Dis., 28, 893-897.
41. PalmerNO, MartinMV, PealingR, IrelandRS,RoyK, SmithA, BaggJ (2010). Antibiotic prescription knowledge of National Health Service general dental practitioner in England and Scotland. J. Antimicrob. Chemother., 47(2), 233-237
42. RoseLF, GencoRJ, CohenDW, MealeyBL (eds.) (2000). Periodontal Medicine.
43. WaltersMP, LittlewoodJM (1996). Pancreatin preparations used in the treatment of cystic fibrosis-lipase content and in vitro release. Aliment. Pharmacol. Ther., Jun, 10(3), 433-440
