Irkutsk, Irkutsk region, Russian Federation
Nasopharyngeal flora contributes much to the development of many diseases, including the urinary system diseases. The aim was to compare the vaginal microbiota biotope and nasopharynx microbiota in women with reproductive disorders (RD). The study involved 97women with RD (infertility, miscarriage). The control group comprised women with chronic endometritis (CE), RD and chronic tonsillitis (CT) (n=65), mean age was 31.0±5.3. CE was diagnosed using histologic analysis and ultrasound studies. The comparison group consisted of 32 women with RD without CE and HT, representative by age. Endometrial sampling was conducted by endometrial pipelle biopsy taken on 5–11th days of the menstrual cycle. Nasopharyngeal swabs were taken on an empty stomach. Due to reduced indigenous microbiota in the studied habitats the number of opportunistic pathogenic microflora such as Staphylococci, Enterococci, fungi, E.coli and etiologically significant Streptococcus (in nasopharynx) was increased. Streptococci in the nasopharynx indicate that the troubles are in vaginal biotope, which leads to inflammatory diseases and reproductive disorders. Everything mentioned demonstrates common etiopathogenic mechanisms for the development of pathological processes of various localizations. Thus, it is important to pay close attention to all rehabilitation centers specializing on chronic infections, which will improve the treatment of СE.
chronic endometritis, tonsillitis, opportunistic pathogenic microflora, nasopharynx, vaginal biotope
1. GromadaNA (2003). Chronic tonsillitis and its in-fluence on the course of other diseases [Khronicheskiy tonzillit i ego vliyanie na techenie drugikh zabolevaniy]. Vestnik Kyrgyzsko-Rossiyskogo Slavyanskogo Universiteta, 3(7), 121-124
2. KiraEF (1994). Clinic and diagnosis of bacterial vaginosis [Klinika i diagnostika bakterial’nogo vaginoza]. Akusherstvo i ginekologiya, (2), 32-35.
3. KorotyaevAI, BabichevSA (1998). Medical microbi-ology, immunology and virology [Meditsinskaya mikrobi-ologiya, immunologiya i virusologiya], 592.
4. KungurtsevaEA, PopkovaSM, LeshchenkoOY (2014). Mutual formation of open cavities mucosal microflora of different habitats in women as an important factor of their reproductive health [Vzaimoformirovanie mikroflory slizistykh obolochek otkrytykh polostey razlichnykh bio-topov u zhenshchin kak vazhnyy faktor ikh reproduktiv-nogo zdorov’ya]. Vestnik RAMN, (9-10), 27-33.
5. MetelskayaVA, AleshkinVA, VoropaevaEA, Karau-lovAV, NesvizhskiyYV (2010). Colonization resistance and immunological reactivity of the oropharynx mucosa in children under normal conditions and at a bronchial and pulmonary diseases [Kolonizatsionnaya rezistentnost’ i immunologicheskaya reaktivnost’ slizistoy rotoglotki u detey v norme i pri bronkholegochnykh zabolevaniyakh]. Vestnik RAMN, (7), 10-15.
6. MotovilovaTM, GrechkanevGO, KachalinaTS (2015). Comparative analysis of the microflora of uterine cavity and tonsils in patients with persistent endometritis[Sravnitel’naya kharakteristika mikroflory polosti matki i nebnykh mindalin u patsientok s persistiruyushchim endometritom]. Meditsinskiy al’manakh, (4), 105-107.
7. MotovilovaTM, KachalinaTS, AnikinaTA (2013). Alternative approach to the treatment of patients with chronic nonspecific endometritis [Al’ternativnyy podkhod k lecheniyu bol’nykh s khronicheskim nespetsificheskim endometritom]. Russkiy meditsinskiy zhurnal. Akusherstvo i ginekologiya, (14), 751-755.
8. On the unification of microbiological (bacteriological) methods of research used in clinical diagnostic laborato-ries of healthcare institutions. Order of the Ministry of Health of the USSR N535 d.d. 22.04.1985 [Ob unifikatsii mikrobiologicheskikh (bakteriologicheskikh) metodov issledovaniya, primenyaemykh v kliniko-diagnosticheski-kh laboratoriyakh lechebno-profilakticheskikh uchre-zhdeniy. Prikaz MZ SSSR No 535 ot 22.04.1985] (1989).
9. PetrosyanLA (2008). Immunological aspects of habit-ual loss pregnancy (review) [Immunologicheskie aspekty privychnoy poteri beremennosti (obzor literatury)]. Problemy reproduktsii, (2), 62-67
10. PokrovskiyVI, PozdeevOK (1998). Medical microbi-ology [Meditsinskaya mikrobiologiya], 1200.
11. Treatment protocol. Intestinal dysbiosis. Application standard OST91500.11.00042003. Approved 09.06.2003 [Protokol vedeniya bol’nykh. Disbakterioz kishechni-ka. Otraslevoy standart OST 91500.11.00042003. Utv. 09.06 2003] (2003)
12. Tetruashvili NK (2010). Prenatal care in women with habitual abortion caused by immunological disorders [Ve-denie beremennosti u zhenshchin s privychnym vykidysh-em, obuslovlennym immunologicheskimi narusheniyami]. Consilium medicum, (6), 34-38.
13. TurovskiyAB, KolbanovaIG (2009). Chronic tonsillit-is- modern ideas [Khronicheskiy tonzillit - sovremennye predstavleniya]. Otorinolaringologiya, (5), 16-21.
14. YankovskitDS (2003). Composition and functions of microbiocenosis of different human biotopes [Sos-tav i funktsii mikrobiotsenozov razlichnykh biotopov cheloveka]. Probiotiki v sovremennoy meditsine. Zdorov’e zhenshchiny, (4), 145-158
