The aim of the research was to explore range of skin and mucous membrane pathology in patients with HIV infection in Sverdlovsk region, assess the impact on it the severity of immunodeficiency, systemic receiving antiretroviral drugs.The study included 459 patients with HIV infection. The patients were divided into two groups: Group 1 (core) – patients on antiretroviral therapy (ART), 133 people, group 2 (control group) – 326 HIV-persons who are not receiving ART. The control group is represented by two subgroups: 2A – patients with a level of CD4+ T-lymphocyte cells ≥ 350/μl (153 patients) and 2B – 173 HIV-positive with the amount of CD4+ cells less than 350/μl.Among HIV-infected patients not receiving ART, with the level of CD4+ T-cells below 350 cells/μl were significantly more lesions detected candida, hairy leukoplakia tongue (p < 0,01), seborrheic dermatitis, psoriasis (p < 0.05), when CD4+ ≥ 350 cells/μl – skin xerosis (p < 0,05). On the background of the systematic intake of antiretroviral drugs we detected reduced frequency of candidiasis (from 21.5 % to 6.8 %), of herpes zoster (from 6.1 % to 0.8 %), and of hairy leukoplakia (absent on the background of ART), on the other hand we revealed increase occurrence of impairments caused by human papilloma virus.
HIV infection, CD4+ T-lymphocytes, antiretroviral therapy, skin diseases
1. BartlettJ, GallantJ, FamP (2012). Clinical aspects of HIV infection [Klinicheskie aspekty VICh-infektsii], 528
2. KungurovNV (2015). Syphilis and sexually-transmitted infections: atlas [Sifilis i infektsii, peredavaemye polovym putem: atlas], 184
3. PokrovskiyVV (2013). HIV infection and AIDS. National guidelines [VICh-infektsiya i SPID. Natsional’noe rukovodstvo], 608.
4. AnwarKP, MalikA, SubhanKH (2012). Profile of candidiasis in HIV infected patients. Iran J. Microbiol., 4(4), 204-209.
5. ChatzikokkinouP, SotiropoulosK, KatoulisA,LuzzatiR, TrevisanG (2008). Seborrheic dermatitis - an early and common skin manifestation in HIV patients. Acta Dermatovenerol. Croat., (16), 226-230.
6. ЕsserS (2015). HIV-associated skin and mucocu-taneous diseases. In: HIV 2015/2016, 613-626.
7. PaparizosVA (2013). Dermatologic images in HIV patients. Hellenic Dermatovenerologica Review, (24), 7-15.
8. PorrasB, CostnerM, Friedman-KienAE, CockerellCJ (1998). Update on cutaneous manifestations of HIV infec-tion. Med. Clin. North Am., 82(5), 1033-1080.
9. RothengatterS, SehrT, GholamP, DuraniH, Hart-mannM (2009). Skin diseases and sexually transmitted diseases in HIV-infected patients on HAART compared to a non-infected population - results of a retrospective study. J. Dtsch. Dermatol. Ges., (7), 527-532.
10. ThomasSL, HallAJ (2004). What does epidemi-ology tell us about risk factors for herpes zoster? Lancet Infect. Dis., (4), 26-33.
11. WölferLU, Djemadji-OudjielN, HileteworkM,TebbeB, HusakR, GoerdtS, OrfanosCE (1998). HIV-as-sociated psoriasis. Clinical and histological observations in 36patients. Hautarzt, 49(3), 197-202.
12. ZallaMJ, SuWP, FranswayAF (1992). Dermato-logic manifestations of human immunodeficiency virus infection. Mayo Clin. Proc., (67), 1089-1108
