Diseases caused by disturbance of endogenous and exogenous pancreatic functions (endocrine function – diabetes mel-litus (DM) and exocrine function – chronic pancreatitis (CP)), are widely distributed in the world due to alcohol abuse, unhealthy lifestyle and negative influence of the environment. These pathologies often associate with abnormal liver functions. The goal of the study was to explore the features of the liver enzymes in 47 patients with a diagnosis of DM and CP. We revealed increase in the content of liver enzymes (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase) in disturbance of pancreatic endocrine function. This dysfunction may be caused by hepatitis B and C, and fatty liver disease. Concentration of liver enzymes in the blood of individuals with hepatitis B and C was also increased. Levels of liver enzymes in patients with exocrine pathology ranged in the reference values. The reason could be the remission of CP in the examined patients. These studies require involvement of larger number of patients with the remission of the disease, and a new group of patients with CP exacerbation stage. Also additional functional and biochemical studies are necessary to identify the diagnosis of fatty liver.
diabetes mellitus, chronic pancreatitis, liver enzymes, hepatitis
1. AryamkinaOL, AkhmedovaVK, BlagovskayaMA, VasilyevaIV, TrifonovaMS (2013). Chronic pancreatitis and diabetes mellitus at chronic hepatitis B and C [Khron-icheskiy pankreatit i sakharnyy diabet pri khronicheskom gepatite V i S]. Ul’yanovskiy mediko-biologicheskiy zhurnal, (1), 50-58
2. DorofeevAE, RudnenkoNN (2015). Chronic pancre-atitis: modern approaches to the treatment [Khronich-eskiy pankreatit: sovremennye podkhody k lecheniyu]. Novosti meditsiny i farmatsii, (3), 26-28.
3. KlyaritskayaIL, MaksimovaEV (2012). Comorbidity of diabetes mellitus and liver diseases [Komorbidnost’ sakharnogo diabeta i zabolevaniy pecheni]. Krymskiy terapevticheskiy zhurnal, (2), 109-115.
4. KoshikovaIN, KhamnuevaLY (2010). Hepatic diseases in patients with type 2 diabetes [Zabolevaniya pecheni u bol’nykh sakharnym diabetom 2 tipa]. Sibirskiy meditsins-kiy zhurnal, (4), 8-11.
5. IDF Diabetes Atlas [Mezhdunarodnyy atlas diabeta]. Available at: http://www.diabetesatlas.org/key-mes-sages.html (accessed April 5, 2016).
6. KhamnuevaLY, MalovIV, DavydovaAV, AndreyevaLS, ShagunOV (2002). Role of hepatotropic viruses in patho-genesis of diabetes mellitus [Rol’ gepatotropnykh virusov v patogeneze sakharnogo diabeta]. Sibirskiy meditsinskiy zhurnal, (6), 9-13.
7. TsimmermanYS (2009). Clinical gastroenterology[Klinicheskaya gastroenterologiya], 416.
8. LonardoA, AdinolfiLE, PettaS, CraxiA, LoriaP (2009). Hepatitis C and diabetes: the inevitable coin-cidence? Expert Review of Anti-Infective Therapy, 7(3), 293-308
