Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Ultrasound characteristic of thymus gland was studied in 109 mature newborns at the 3-5th days of life. All the examined patients were divided into 4 groups. The first group (control) included 30 healthy newborns of 38-40 weeks from mothers with physiologic course of pregnancy. The second group had 28 newborns whose mothers at early stages of gestation suffered influenza virus А(Н3N2) with antibody titer 1:4-1:16; in the third group there were 26 children of 38-40 weeks from mothers who suffered in the first trimester of pregnancy influenza virus A(H3N2) with antibody titer 1:8-1:32; the fourth group consisted of 25 newborns from mothers who suffered at early stages of gestation influenza virus A(H3N2) with antibody titer 1:32-1:128. The children in the second and the third group in comparison with the first one did not have any changes of organometric parameters of the immune organ. In the newborns of the fourth group the length of the thymus gland decreased till 3.8±0.11 cm, the width till 2.4±0.06 cm, the mass till 8.6±0.53 g and the volume of the organ till 6.0±0.37 sm3. In the first group these parameters were 4.2±0.09 cm (р<0.05), 2.8±0.05 cm (р<0.001), 10.5±0.37 g (р<0.01), 7.4±0.25 sm3 (р<0.01), respectively. This suggests the suppression of organogenesis of thymus in children with antenatal anamnesis burdened with influenza virus А(Н3N2) with antibody titer 1:32-1:128 in their mothers at early stages of gestation
thymus gland, full term newborn, influenza A(H3N2), antibody titers, pregnancy, the first trimester of pregnancy.
1. Andrievskaya I.A. Steroidogenesis processes in mother-placenta-fetus system in patients with acute herpes infection. Bulleten´ fiziologii i patologii dyhaniâ 2004; 17:65-68 (in Russian).
2. Гориков И.Н. Immune-serological characteristic of influenza virus A(H3N2) of women in the first trimester of pregnancy. Dal´nevostochnyy zhurnal infektsionnoy patologii 2006; 9:94-95 (in Russian).
3. Gorikov I.N., Lutsenko М.Т., Аndrievskaya I.А. Ultrasound markers of primary placental insufficiency and system inflammatory response at influenza virus A(H3N2) in women in the first trimester of pregnancy. Bulleten´ fiziologii i patologii dyhaniâ 2016; 59:44-48 (in Russian).
4. Voevodin S.M. Possibilities echographic study of the thymus in newborn. Voprosy okhrany materinstva i detstva 1989; 34(4):38-43 (in Russian).
5. Zabolotskikh T.V., Grigorenko A.A., Gorikov I.N. The changes of ultrasound and morphological constitution of the thymus gland in newborns with intrauterine parainfluenza of 1 and 3 types. Bulleten´ fiziologii i patologii dyhaniâ 2013; 50:94-98 (in Russian).
6. Kuz´menko L.G., Bakhaeddin A.May., Neizhko L.Yu., Vakhrusheva S.I., Gerberg A.M. The method of ultrasound scanning in the evaluation of the state of the thymus gland in children of different ages. Pediatriya 1994; 6:56-58 (in Russian).
7. Kuz´menko L.G., Semenikhina K.N., Neizhko L.Yu., Sarker L., Vakhrusheva S.I. Assessment of the value of the thymus gland in children of the first two years of his life according to the ultrasound scanning. Pediatriya 2002; 6:22-26 (in Russian).
8. Mirchink E.P., Zuev V.A., Miroshina E.K. Slow influenza infection that develops in mice offspring as a result of females infected during pregnancy. Voprosy virusologii 1984; 29(1):32-35 (in Russian).
9. Sirotina O.B. The role of ultrasonography in the diagnosis of thymomegaly in children in the neonatal period (lecture). Dal´nevostochnyy meditsinskiy zhurnal 2000; 3:117-120 (in Russian).
10. Yaglova N.V., Obernikhin S.S. Changing the process of differentiation of thymic T cells in the offspring of female mice who underwent stimulation of the immune system in early pregnancy Byulleten´ eksperimental´noy biologii i meditsiny 2015; 160(11):613-616 (in Russian).
