Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
Irkutsk, Irkutsk region, Russian Federation
The research was carried out on 9rabbits (males) of Chinchilla breed with modeling of standard perforating fracture of femoral bone. We performed intraosseous introduction of nanocomposite elemental selenium and heteropolysaccharide arabinogalactan 50mg Se/kg to individuals of experimental group (n=3) and NaCl 0,9% to individuals of control group (n=6). It was established that local intraosseous introduction of the nanocomposite with perforated fracture model did not affect basal metabolic indicators (body temperature, oxygen consumption, carbon dioxide production), but boosted the metabolic processes in the area of the surgical wound from the 9th to 21st days. It proves the bioavailability of the drug and the possibility of creating a local depot of selenium using a nanocomposite.
selenium nanocomposite, reparative regeneration, basal metabolism, thermography, bone fracture
1. GmoshinskyIV, MazoVK (2006). Minerals in human nutrition. Selenium: absorption and bioavailability [Min-eral’nye veshchestva v pitanii cheloveka. Selen: vsasyvanie i biodostupnost’]. Voprosy pitaniya, 75(5), 15-21.
2. DrzhevetskayaIA (1994). Fundamentals of physiology of metabolism and endocrine systems [Osnovy fiziologii obmena veshchestv i endokrinnoy sistemy], 255.
3. KazimirkoVK, MaltsevVI, ButylinVY, GorobetsNI(2004). Free radical oxidation and antioxidant therapy [Svobodnoradikal’noe okislenie i antioksidantnaya terapiya], 160.
4. MohortEG (2003). The role of selenium in the pathogenesis of iodine deficiency [Rol’ selena v patogeneze yodnoy nedostatochnosti]. Belorusskiy meditsinskiy zhurnal,(3), 88-94.
5. PopovaLG, RodionovaLV , PrudnikovaNV, Tsys-lyakES, LebedevVF, LepekhovaSA. Thermographic measurements in the process of reparative regeneration of bone tissue in experimental animals [Termograficheskie izmereniya v protsesse reparativnoy regeneratsii kostnoy tkani u eksperimental’nykh zhivotnykh]. Biotekhnologiya. Vzglyad v budushchee: Materialy I Mezhdunarodnoy nauch-noy Internet-konferentsii (Kazan’, 26-27 marta 2013 g.), 256-259.
6. RodionovaLV, PrudnikovaNV, PopovaLG, Lebe-devVF, ShuryginaIA, ShuryginMG, YakuninaNP, Le-pekhovaSA (2013). Dynamics of thyroid hormones in the performance of a standard fracture model in rabbits [Dinamika gormonov shchitovidnoy zhelezy pri vypol-nenii modeli standartnogo pereloma u krolikov]. Bulleten’ Vostocno-Sibirskogo naucnogo centra, 2(2), 161-166.
7. ShuryginaIA, RodionovaLV, ShuryginMG, SukhovB G, KuznetsovSV, PopovaLG, DryominaNN (2014). Using confocal microscopy to study the effect of an original pro-enzyme se/arabinogalactan nanocomposite on tissue regeneration in a skeletal system [Ispol’zovanie metoda konfokal’noy mikroskopii dlya izucheniya vliyaniya original’nykh pro-fermentnykh nanoglikon»yugatov elementnogo selena na regeneratsiyu opornykh tkaney]. Materialy XIV mezhdunarodnoy molodezhnoy konferentsii po lyuministsentsii i lazernoy fizike, 157-158.
8. .ShuryginaIA, RodionovaLV, ShuryginMG, SukhovBG, KuznetsovSV, PopovaLG, DryominaNN (2015). Using confocal microscopy to study the effect of an original pro-enzyme se/arabinogalactan nanocomposite on tissue regeneration in a skeletal system [Konfokal’naya mikroskopiya v izuchenii vliyaniya original’nykh pro-fermentnykh nanoglikokon»yugatov elementnogo selena na regeneratsiyu opornykh tkaney]. Izvestiya Rossiyskoy akademii nauk. Seriya fizicheskaya, 79(2), 256-258.
9. AltayMA, ErtürkC, SertC, OncelF, IsikanUE(2012). Bioelectrical impedance analysis of basal metabolic rate and body composition of patients with femoral neck fractures versus controls. Eklem Hastalik Cerrahisi, 23(2), 77-81.
10. DumitrescuAM, RefetoffS (2011). Inherited defects of thyroid hormone metabolism. Ann. Endocrinol. (Paris), 72(2), 95-98. doi:https://doi.org/10.1016/j.ando.2011.03.011.
11. HuangZ, RoseAH, HoffmannPR (2012). The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal, 16 (7), 705-743. doi:https://doi.org/10.1089/ars.2011.4145.
12. SadeghianS, KojouriGA, MohebbiA (2012). Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite. Biol. Trace Elem. Res., 146(3), 302-308. doi:https://doi.org/10.1007/s12011-011-9266-8.
13. WangH, ZhangJ, YuH (2007). Elemental selenium at nano size possesses lower toxicity without compromis-ing the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic. Biol. Med., 42 (10), 1524-1533.
14. ZhangJ, WangX, XuT (2008). Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol. Sci., 101 (1), 22-31. 15. ZhangJS, GaoXY, ZhangLD, BaoYP (2001). Bio-logical effects of a nano red elemental selenium. Biofactors,15 (1), 27-38.
