Irkutsk, Irkutsk region, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
Ulan-Ude, Ulan-Ude, Russian Federation
The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant composition increases contingency between oxidation and phosphorylation, as well as coefficients of respiratory stimulation and respiratory control by 17 % (р < 0.05) and 15 % (р < 0.05) respectively as compared to the control group. The tested herbal medicine increases the ATP content by 29 % (р < 0.05) and improves the activity of pyruvate kinase and H+-ATPase by 1.9 and 1.2 times respectively which indicates a partial restoration of energy metabolism in hepatocytes. The results of the research allow us to recommend the plant composition for its further study as a potential prospective hypolipidemic remedy for non-alcoholic fatty liver disease.
dyslipoproteidemia, liv er, mitochondrion, energy metabolism, phosphorylation, oxidativ e stress, adenylpyrophosphate, pyruv ate kinase, hypolipidemic plant composition
1. Azhunova TA, Lemza SV (2015). Influence of multicomponent plant remedy on the course of experimental dyslipoproteinemia [Vliyanie mnogokomponentnogo rastitel’nogo sredstva na techenie eksperimental’noy dislipoproteidemii]. Byul. VSNTs SO RAMN, (2), 66-69.
2. Azhunova TA, Nikolaev SM (2009). Hypolipidemic and anti-inflammatory properties of the plant-based drug «Kamfora-25» [Gipolipidemicheskie i protivovospalitel’nye svoystva rastitel’nogo sredstva «Kamfora-25»]. Rastitel’nye resursy, 45 (4), 105-111.
3. Lubsandorzhieva PB (2009). The content of biologically active substances in some Transbaikal plants and their antioxidant activity [Soderzhanie biologicheski aktivnykh veshchestv v nekotorykh rasteniyakh Zabaykal’ya i ikh antioksidantnaya aktivnost’]. Himija rastitel’nogo syr’ja, (3), 133-137.
4. Prokhorova MI (ed.) (1982). Methods of biochemical studies: lipid and energy metabolism [Metody biokhimicheskikh issledovaniy: lipidnyy i energeticheskiy obmen], 271.
5. Misharina TA (2009). Antioxidant properties of essential oils [Antioksidantnye svoystva efirnykh masel]. Prikladnaya biokhimiya i mikrobiologiya, 45 (6), 710-716.
6. Nikolaev SM (2012). Phytopharmacotherapy and phytopharmacoprophylaxis of diseases [Fitofarmakoterapiya i fitofarmakoprofilaktika zabolevaniy], 284.
7. Severin SE, Solov’yeva GA (eds.) (1989). Practicum on Biochemistry: Teaching Guide [Praktikum po biokhimii: uchebnoe posobie], 509.
8. Toropova AA, Lemza SV, Razuvaeva YaG, Gulyaev SM, Azhunova TA (2015). Effect of plant composition on the oxidative stress in white rats with non-alcoholic fatty liver disease [Vliyanie rastitel’noy kompozitsii na okislitel’nyy stress u belykh krys pri nealkogol’noy zhirovoy bolezni pecheni]. Sibirskiy meditsinskiy zhurnal (Irkutsk), (5), 117-119.
9. Badreldin HA, Blunden G, Tanira MO, Nemmar A (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, (46), 409-420.
10. Long L, Lei L, Ling C, Xiaoyu L, Yaping X, Jie R, Jin F, Yan Q (2015). Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats. Journal of Pharmacological Sciences, (127), 244-250.
11. Ni HC, Li J, Jin Y, Zang HM, Peng L (2004). The experimental animal model of hyperlipidemia and hyperlipidemic fatty liver in rats. Chin. Pharmacol. Bull., (20), 703-708.
12. Panov A, Dikalov S, Shalbuyeva N, Hemendinger R, Greenamyre JT, Rosenfeld J (2007). Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice. Am. J. Physiol. Cell Physiol., 292 (2), 708-718.
