The analysis of work on identification and registration of complications of medicinal therapy in medical institutions of the Irkutsk region showed that the frequency of undesirable medicinal reactions at inpatients is more senior than 60 years makes from 10 % to 25 %. At advanced age the special place is taken by dysfunction of a digestive tract and allergic reactions at purpose of cardiovascular medicines, and also antibacterial and the antiglaucomous medicines. The number of cases of absence of therapeutic effect of PM in this age group made 18,9 %, reactions from the digestive tract – 15,5 % of cases, thus in 6,5 % pseudomembranous colitis was registered. It is established that risk factors of emergency of such reaction were the background pain or depressive syndrome, accompanying application of more than three drugs and absence of the scheme of a titration of dosages.
safety monitoring, medicine, undesirable collateral reaction
1. Astakhova AV, Lepakhin VK. (2008). Drugs. Adverse drug reactions and control of safety [Lekarstva. Neblagopriyatnye pobochnye reaktsii i kontrol’ bezopasnosti; 2-e izd., ispr. i dop.], 256.
2. Belousov YB, Leonova MV, Belousov DY, Vyalkov AI, Vorobyev PA. (2002). Fundamentals of clinical pharmacology and rational pharmacotherapy: guidelines for the practicing doctors [Osnovy klinicheskoy farmakologii i ratsional’noy farmakoterapii: ruk-vo dlya praktikuyushchikh vrachey], 368.
3. Belousov YB, Leonova MB. (2008). Features of application of a medicine in geriatric practice [Osobennosti primeneniya lekarstva v geriatricheskoy praktike]. Farmateka, (8), 13-19.
4. Verlan NV, Rybalko MV, Dvoynikova NA, Kochkina EO, Gumennikova EN. (2013). Problems of monitoring of safe use of medicines [Problemy monitoringa bezopasnogo ispol’zovaniya lekarstvennykh sredstv]. Sibirskiy meditsinskiy zhurnal, (6), 113-114.
5. Verlan NV, Kochkina EO, Dvoynikova NA, Rybalko MV, Popadyuk AV. (2014). Carrying out the monitoring of safety of medicines [Provedenie monitoringa bezopasnosti lekarstvennykh sredstv]. Vestnik Buryatskogo gosudarstvennogo universiteta. Seriya: Meditsina, farmatsiya, (12), 13-16.
6. On the approval of procedure of administering medical aid on clinical pharmacology: Order N 575n d.d. 02.11.2012 of the Ministry of Health of the Russian Federation [Ob utverzhdenii poryadka okazaniya meditsinskoy pomoshchi po profilyu «Klinicheskaya farmakologiya »: Prikaz № 575n ot 02.11.2012 Ministerstva zdravookhraneniya Rossiyskoy Federatsii].
7. N 61-FZ (as revised in 27.07.2010) [Ob obrashchenii lekarstvennykh sredstv: Federal’nyy zakon ot 12.04.2010 g. № 61-FZ (s izmeneniyami ot 27.07.2010 g.)].
8. On the approval of procedure of monitoring of safety of drugs for medical application, registration of side effects, unexpected adverse reactions at the use of drugs for medical application: Order N 757n d.d. 26.08.2010 of the Ministry of Health of the Russian Federation [Ob utverzhdenii poryadka osushchestvleniya monitoringa bezopasnosti lekarstvennykh preparatov dlya meditsinskogo primeneniya, registratsii pobochnykh deystviy, ser’eznykh nezhelatel’nykh reaktsiy, nepredvidennykh nezhelatel’nykh reaktsiy pri primenenii lekarstvennykh preparatov dlya meditsinskogo primeneniya: Prikaz № 757n ot 26.08.2010 Ministerstva zdravookhraneniya Rossiyskoy Federatsii].
9. Khubiyeva MY, Yurgel NV, Lepakhin NV. (2008). Determination of the degree of reliability of relationship of causal relationship “undesirable adverse drug reaction - drug” [Opredelenie stepeni dostovernosti prichinno-sledstvennoy svyazi “nezhelatel’naya pobochnaya reaktsiya - lekarstvennoe sredstvo”: metod. rekomendatsii],14.
10. Yurgel NV, Khubiyeva MY, Glagolev SV, Malikova AV. (2009). Algorithm of interaction of participants of system of PV on the identification and work with spontaneous messages [Algoritm vzaimodeystviya uchastnikov sistemy farmakonadzora po vyyavleniyu i rabote so spontannymi soobshcheniyami: Metod. rekomendatsii], 22.
