Blagoveschensk, Blagoveshchensk, Russian Federation
Habarovsk, Khabarovsk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
Blagoveschensk, Blagoveshchensk, Russian Federation
The contents of anti-inflammatory and pro-inflammatory cytokines in 95 women in the first trimester of gestation were studied. The first (control) group included 25 women with physiologic course of pregnancy; the second group consisted of 25 patients with exacerbation of chronic simple bronchitis caused by influenza virus B (antibody titers were 1:16-1:64); the third group consisted of 24 pregnant women with exacerbation of chronic simple bronchitis under influenza virus В (antibody titers were 1:32-1:128); the fourth group consisted of 21 women with exacerbation of chronic simple bronchitis induced by influenza virus B (antibody titers were 1:64-1:256) at early stages of gestation. In the patients of the second group in comparison with the patients of the first group there was an increase of IL-4 till 19.7±2.17 pg/ml, of TNF-α till 33.4±3.09 pg/ml and of INF-γ till 30.9±2.64 pg/ml (in the control it was 12.9±1.16 pg/ml, р<0.01; 24.7±2.27 pg/ml, р<0.05 and 22.3±2.08 pg/ml, р<0.05, respectively). In the third group in comparison with the second group there was no growth of anti-inflammatory and pro-inflammatory cytokines. In the fourth group in comparison with the second group there was the biggest increase of IL-4 till 27.7±2.42 pg/ml (р<0.05), of TNF-α till 43.6±2.79 pg/ml (p<0.05) and of INF-γ till 40.7±2.96 pg/ml (p<0.05). This suggest the paramount importance of the growth of anti-virus antibodies titers in the pathogenesis of exacerbation of chronic simple bronchitis under influenza virus B in women at early stages of gestation.
pregnancy, chronic bronchitis, influenza B, titers of anti-viral antibodies, cytokines
1. Avdeeva Zh.I., Alpatova N.A., Akol´zina S.E., Medunitsyn N.V. Immunoadjuvant effect of cytokines. Pacific medical journal 2009; 3:19−22 (in Russian).
2. Aksenov O.A., Osipova Z.A. The role of viral mix neuraminidase in the interferon system. Voprosy virusologii 1990; 35(6):483−486 (in Russian).
3. Bogomolov S.V. The interferon system: modern ideas of its structure, organization and role in realization of immunity. Infektsionnye bolezni 2009; 7(1):49−53 (in Russian).
4. Gorikov I.N., Reznik V.I. Morphological structure of placenta and health status of newborns with intrauterine influenza B. Dal´nevostochnyy zhurnal infektsionnoy patologii 2008; 13:36−40 (in Russian).
5. Karpukhin G.I., editor. Influenza: the manual for doctors. St. Petersbug: Gippokrat; 2001 (in Russian).
6. Zurochka A.V., Dvorchik E.E., Kvyatkovskaya S.V., Shestakova E.V. Evaluation of the immune status and cytokine production in patients with atopic asthma and mixed. Meditsinskaya immunologiya 2009; 11(2-3):279-286 (in Russian).
7. Lutsenko M.T., Perelman J.M., Kolosov V.P., Pirogov A.B., Odireev A.N., Samsonov V.P. The mechanisms of pathogenesis and trends of correction of non-specific lung diseases. Vol.1. Blagoveshchensk; 2005 (in Russian).
8. Nosik N.N. Cytokines in viral infections. Voprosy virusologii 2000; 45(1):4−10 (in Russian).
9. Kolosov V.P., Kolosov А.V. Patent 2240725 RU. Method for predicting the progress in respiratory tract obstruction; published 27.11.2004 (in Russian).
