The parasitic disease such as octodectosis widely spread in our country as well as abroad may cause significant economic damage. In fur farms of the Russian Federation the extensity of Otodectescynotis infection is in the range from 35 to 85% and in some farms reaches 100%. Objective of research: to determine the efficacy of a new drug produced on the basis of levofloxacin, clotrimazole, dexamethasone, moxidectinused forotodectos is in foxes and to identify by histological examination the effect of the composition of active ingredients onthe inner skin surface of the ear in foxes with otodectosis. Materials and methods: microscopic examination of scrapings was performed using abiotic research method of A.M. Priselkova. Histological sections were prepared according to the standard techniques. Morphometry was performed using the program ImageJ. Results and discussion: the results of clinical and laboratory studies of foxes at ZAO «Saltykovsky» have revealed that the rate of Otodectescynotis infection in adult stock was 73,7%. No complications and side effects were observed during the treatment.The 100% efficacy of eardrops was confirmed by two acarological studies. The article presents the description of histological preparations of the inner surface of the ears of foxes before and after treatment forotodectosis. Positive morphological changes in the skin were revealed. The optimal microstructural organization of tissue has been restored after using the drug, in particular, the total skin thickness has been reduced by 2.2 times compared to the values provided from the group of sick animals (otodectosis). Thus, it was found that there is a tendency to the regeneration processes of skin in the inner surface of the auricle of treated animals
otodectosis, foxes, auricle, moxidectin, histology, morphometry.
Введение
Пушное звероводство – одна из наиболее рентабельных отраслей животноводства, которая обеспечивает продукцией, пользующейся постоянным спросом на мировом рынке.
Важной задачей звероводства на современном этапе является дальнейшее увеличение продукции, что может быть достигнуто за счет интенсивного развития отрасли. Несмотря на большие достижения, звероводство еще несет значительные потери от различных болезней пушных зверей.
Из множества факторов, снижающих эффективность данной отрасли, следует отметить кожные болезни пушных зверей, которые приводят к снижению качества получаемых шкурок, что отрицательно сказывается на рентабельности звероводческих хозяйств [7, 9].
Известно, что кожа является эпителиально-соединительнотканным органом и выполняет множество функций, которые во многом обеспечивают постоянство внутренней среды организма. Заболевания кожи находятся в патогенетической связи с другими органами и системами, отражающими гомеостаз и здорового, и больного организма во всех его сложных проявлениях [4].
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