The article analyzes the position of a pathogenic biochemical indicators of status and antioxidant defense in patients with MS. It is shown that the degree of impairment of the insulin-receptor interaction in patients with MS is closely linked with the degree of lipid peroxidation and the content of Amadori products. Observed in MS accumulation of advanced glycation end-products of non-enzymatic proteins and lipids underlies the development of oxidative stress, forming an inadequate regulation of vascular tone, and can be considered as an additional criterion of reduction of the reserve capacity of the organism. It was found that the impact of courses of herbal medicine in combination with TMS has a strong antioxidant effect, which is realized by the direct action of antioxidant ingredients that make up phytococktails and thanks magnetobiological effects of transcranial magnetic effects. The set of identified effects, including a reduction in the concentration of non-enzymatic glycation end products, allows us to consider this approach as an effective technology pathogenetic correction of the main manifestations of MS and its prevention of the most common complications.
metabolic syndrome, herbal medicine, transcranial magnetic stimulation, lipid peroxidation, antioxidant enzymes, non-enzymatic glycation end products
1. Ansari N.A., Rashid Z. Nefermentativnoe glikirovanie belkov: ot diabeta do raka. Biomeditsinskaya khimiya - 2010, T. 56. - S. 168-178.
2. Bobrovnitskiy I.P., Sergeev V.N., Nagornev S.N. i dr.Diagnosticheskiy algoritm issledovaniya rezervov zdorov´ya patsientov i perspektivy nutritivnometabolicheskoy korrektsii. Terapevt. 2013. № 3. S. 65-75.
3. Geraskina L.A. Optimizatsiya antigipertenzivnoy terapii u bol´nykh s distsirkulyatornoy entsefalopatiey i ostatochnymi yavleniyami narusheniy mozgovogo krovoobrashcheniya: Avtoref. dis.... kand.med. nauk. - M., 2000. - 23 s.
4. Edelev D.A., Bobrovnitskiy I.P., Mikhaylenko L.V.,Frolkov V.K. Primenenie fizicheskikh i prirodnykh faktorov v vosstanovitel´noy korrektsii funktsional´nykh rezervov cheloveka.-M., Binom.-2009.-263 s.
5. Karpukhin A.V. Razrabotka nemedikamentoznykh sposobov vosstanovitel´noy korrektsii lipidnogo obmena u lits s riskom razvitiya ateroskleroza: Avtoref....dis. kand. med. nauk. - M., 2010. - 24 s.
6. Men´shchikova E.B., Lankin V.Z., Zenkov N.K. i dr.Okislitel´nyy stress. Prooksidanty i antioksidanty. M., 2006. - 556 s.
7. Mikhaylenko L.V. Kompleksnoe primenenie fitoterapii i mineral´nykh vod dlya korrektsii metabolicheskogo sindroma na etape sanatorno-kurortnogo lecheniya: Avtoref.... dis. dok. med. nauk. - M., 2010. - 48 s.
8. Mikhaylenko L.V., Karpukhin A.V., Nagornev S.N., Bobrovnitskiy I.P. Issledovanie antioksidantnykh effektov fitoterapii v sochetanii s preparatom vetoron u bol´nykh arterial´noy gipertenziey. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul´tury. 2010. № 1. S. 15-18.
9. Mikhaylenko L.V., Nagornev S.N., Bobrovnitskiy I.P., Frolkov V.K. Fitoterapiya arterial´noy gipertonii v sochetanii s ozhireniem v sanatorno-kurortnykh usloviyakh //Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul´tury. 2009. № 5. S. 13-17.
10. Nagornev S.N., Sytnik S.I., Bobrovnitskiy I.P. i dr.Farmakologicheskaya korrektsiya protsessa lipoperoksidatsii pri gipoksii i vozmozhnost´ povysheniya vysotnoy ustoychivosti cheloveka s pomoshch´yu preparatov metabolicheskogo tipa deystviya//Vestnik Rossiyskoy akademii meditsinskikh nauk. - 1996, № 7. - S. 53.
11. Serdyuk V.V. Magnitoterapiya: Proshloe, nastoyashchee, budushchee. Spravochnoe posobie. - K., 2004. - 536 s.
12. Transkranial´naya fizioterapiya (Magnitoterapiya i ee sochetanie s elektrostimulyatsiey) / Sbornik statey pod red. A.G. Kulikova, N.V. Bolotovoy, Yu.M. Raygorodskogo. - Saratov, 2013. - 469 s.
13. Kaviarasan K., Arjunan M.M., Pugalendi K.V. Lipid profile, oxidant-antioxidant status and glycoprotein components in hyperlipidemic patients with/without diabetes. Clin.Chim. Acta.- 2005.- Vol. 362.- P. 49-56.
14. Hodgkinson A.D., Bartlett T., Oates P.J., et al.The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Diabetes.- 2003.- Vol. 52.- P. 846-851.
