The article discusses the ways of term formation of transplantology terms. There are several ways of term formation: suffixal, prefixal, prefix-suffixal, as well as Greek and Latin borrowings, that is, internationalisms. The material of the study was the terms of transplantation in parallel corpora of texts in two languages: Russian and Spanish. The purpose of the article is to identify the ways of term formation of transplantology terms in Russian and Spanish. In the term formation of the subject area "Transplantology" in two languages, simple and complex terms are analyzed, formed by root or affix methods. In the Russian language, in the prefix or prefix-suffix method of term formation, there are complex terms, the structure of which includes a double prefix or suffix. In the internationalisms of the Russian language, in comparison with the Spanish language, Greek and Latin affixes stand out. The initial, that is, literal abbreviation in both languages is used as a root lexeme. In the wording of terms of transplantation in Russian and Spanish languages, various models of term formation are distinguished. In the Russian, in comparison with the Spanish, the largest number of word-building models of word formation is distinguished.