Medical Radiology and radiation safety Medical Radiology and radiation safety Медицинская радиология и радиационная безопасность 1024-6177 2618-9615 43729 10.12737/1024-6177-2020-65-6-11-16 Радиационная биология Radiation biology Радиационная биология Embryotoxic and Teratogenic Effects of Gamma Radiation on Zebrafish (Danio rerio) ЭМБРИОТОКСИЧЕСКИЕ И ТЕРАТОГЕННЫЕ ЭФФЕКТЫ γ-ИЗЛУЧЕНИЯ У РЫБ ДАНИО (DANIO RERIO) Исаев Д А Isaev D A

кандидат биологических наук;

candidate of sciences in biology;

 Гурьев Д. В. Guryev D. V.

кандидат биологических наук;

candidate of sciences in biology;

 Блохина Т. М. Blohina T. M. Яшкина Е. И. Yashkina E. I. Осипов А. Н. Osipov A. N.

доктор биологических наук;

doctor of sciences in biology;

 Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России, Москва Россия A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia Russian Federation Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center of FMBA Moscow Russian Federation Институт химической физики им. Н.Н. Семенова РАН Москва Россия N.N. Semenov Institute of Chemical Physics Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И.Бур­на­зяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center (FMBC) FMBA Moscow Russian Federation Федеральный медицинский биофизический центр им. А.И.Бур­на­зяна ФМБА России Москва Россия A.I. Burnasyan Federal Medical Biophysical Center (FMBC) FMBA Moscow Russian Federation 65 6 11 16 https://naukaru.ru/en/nauka/article/43729/view

В обзоре рассмотрены работы, представляющие экспериментальные данные по эмбритоксическим и тератогенным эффектам воздействия ионизирующего излучения у рыб данио (Danio rerio), являющихся удобным модельным объектом экспериментальной эмбриологии и радиационной биологии. Рассматриваются молекулярные механизмы, вовлеченные в ответ на действие ионизирующего излучения и определяющие уровень эмбриональной гибели, либо нарушения дальнейшего развития эмбрионов. Изложены данные об остром и хроническом с различной мощностью дозы воздействиях γ-излучения на эмбрионы различной стадии развития. Показано, что влияние γ-излучения на гибель и развитие эмбрионов рыб данио носит немонотонный характер, зависит как от условий облучения, так и от стадии эмбриогенеза. Результаты таких исследований крайне важны для понимания механизмов формирования радиационно-индуцированных биологических эффектов в эмбриогенезе позвоночных животных, включая человека, а также для разработки методов и подходов к оценке радиационного риска для развивающегося организма.

The review considers investigations presenting experimental data on the embryotoxic and teratogenic effects of exposure to ionizing radiation in zebrafish (Danio rerio) which is a convenient model for experimental embryology and radiation biology. The molecular mechanisms involved in response to the ionizing radiation influence as well as determining the embryonic death level, development disorders of embryos are examined. The data on acute and chronic effects of ionizing radiation on embryos of various stages of development with wide range of dose rates are presented. It was shown that the influence of γ-radiation on the death and development of zebrafish embryos is nonmonotonic and depends both on the irradiation conditions and on the stage of embryogenesis. The results of such studies are extremely important for understanding the mechanisms of radiation-induced biological effects formation in the embryogenesis of vertebrates, including humans, as well as for developing methods and approaches to assessing radiation risk for a developing organism.

 γ-излучение данио эмбриогенез тератогенез эмбриотоксические эффекты γ-radiation zebrafish embryo teratogenesis

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